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HOME> Products> Natural and Chemical compound> Other natural compound> Natural macrocyclic compounds from microorganisms (such as cyclic peptides, and macrolides)

With intriguing biological activities Natural macrocyclic compounds from microorganisms (such as cyclic peptides, and macrolides)

Date：December 09 2025Web Page No：520118

Institute of Microbial Chemistry

We would like to introduce natural bioactive compounds with macrocyclic structures, such as cyclic peptides, macrolides, and cyclic alkenes, from among the physiologically active substances derived from microorganisms discovered and isolated at the Institute of Microbial Chemistry (IMC, also called Bikaken in Japan).
These natural products with unique structures exhibit intriguing biological activities and are attracting attention in the research field.

* SDF (Structure Data Format) files of the compounds are available.
* Please do not hesitate to contact Funakoshi if you need a SDF file and/or bulk purchase (large quantity) of the compounds.
* This product is for research use only.

Product Table
Other bioactive compounds from IMC (BIKAKEN)

Product Table

Click the compound name to jump to the details page, or click the product code to view the price information.

Structural classification	Compound name	Property / Biological activity	Product code
Macrolides	Aplasmomycin A	Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei.	17683
Macrolides	Migrastatin	Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells.	10708
Macrolactams	Bisucaberin	Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis.	14659
Cyclic peptides	Bottromycin A2	Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci).	00592
	Iturin A-2	Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474.	15171
	Plipastatin A1	Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance).	15170
	Phepropeptin A	Phepropeptin A inhibited proteasomal chymotrypsin-like activity.	16964
	Phepropeptin B	Phepropeptin B inhibited proteasomal chymotrypsin-like activity.	16965
	Phepropeptin C	Phepropeptin C inhibited proteasomal chymotrypsin-like activity.	16966
	Phepropeptin D	Phepropeptin D inhibited proteasomal chymotrypsin-like activity.	16967
Cycloalkenes	Rubratoxin A	Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner.	10663

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Other bioactive compounds from IMC (BIKAKEN)

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