Antitumor Bisucaberin

Bisucaberin is a siderophore (iron-chelating compound) isolated from a culture broth of marine bacteria, Alteromonas haloplanktis SB-1123 ^{1, 2)}.

• Specification
• Application Note
• Reference

Specification

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Application Note

• Bisucaberin inhibits the growth of fibrosarcoma 1023 (85% at 18 µg/ml), L1210 (IC₅₀: 3.6 µg/ml) and IMC carcinoma (IC₅₀: 5.1 µg/mL) without affecting their cell viability ¹⁾.
• Biscaberin induces macrophage-mediated tumor cell lysis. The Induced lysis is dependent on concentration of bisucaberin and reaches the maximum (specific lysis: ~70%) at 18 µg/ml. Bisucaberin is considered to have its effect by sensitizing tumor cells to lysis by nonactivated macrophages and not by activating macrophages to be tumoricidal ¹⁾.