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Antitumor Bisucaberin

Date：November 09 2020Web Page No：90002

Institute of Microbial Chemistry

Bisucaberin is a siderophore (iron-chelating compound) isolated from a culture broth of marine bacteria, Alteromonas haloplanktis SB-1123 1, 2).
Bisucaberin

Specification

CAS#112972-60-8
Molecular FormulaC18H32N4O6
Source Alteromonas haloplanktis SB-1123
Molecular Weight400.476
Purity>98% (HPLC)
SolubilitySoluble in DMSO. Poorly soluble in MeOH.
Insoluble in H2O.

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Application Note

  • Bisucaberin inhibits the growth of fibrosarcoma 1023 (85% at 18 µg/ml), L1210 (IC50: 3.6 µg/ml) and IMC carcinoma (IC50: 5.1 µg/mL) without affecting their cell viability 1).
  • Biscaberin induces macrophage-mediated tumor cell lysis. The Induced lysis is dependent on concentration of bisucaberin and reaches the maximum (specific lysis: ~70%) at 18 µg/ml. Bisucaberin is considered to have its effect by sensitizing tumor cells to lysis by nonactivated macrophages and not by activating macrophages to be tumoricidal 1).


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Reference

  1. Kameyama, T., et al., J. Antibiot., 40 (12), 1664～1670 (1987). [PMID:2962972]
  2. Takahashi, A., et al., J. Antibiot., 40 (12), 1671～1676 (1987). [PMID:2962973]

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[Date : April 25 2025 00:06]

Detail Product Name Product Code Supplier Size Price
Bisucaberin, Antitumor
DatasheetThis may not be the latest data sheet. 		14659 IMCInstitute of Microbial Chemistry 1 mg $500

Description M.W. : 400.476　Purity : > 98% (HPLC)　Solubility : Soluble in DMSO, Slightly soluble in methanol, Insoluble in Water Bisucaberin is a siderophore isolated from a culture broth of a marine bacterial strain identified as Alteromonas haloplanktis. Bisucaberin induces macrophage-mediated tumor cell lysis (co-cultured with nonactivated macrophages.
Storage -20°C CAS 112972-60-8
Link

Bioactive Compounds

[Date : April 25 2025 00:06]

Bisucaberin, Antitumor

DatasheetThis may not be the latest data sheet.


  • Product Code: 14659
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description M.W. : 400.476　Purity : > 98% (HPLC)　Solubility : Soluble in DMSO, Slightly soluble in methanol, Insoluble in Water Bisucaberin is a siderophore isolated from a culture broth of a marine bacterial strain identified as Alteromonas haloplanktis. Bisucaberin induces macrophage-mediated tumor cell lysis (co-cultured with nonactivated macrophages.
Storage -20°C CAS 112972-60-8
Link

Bioactive Compounds

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