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Bisucaberin

Date:November 09 2020Web Page No:90002

Bisucaberin

[Date : January 26 2021 23:29]

Detail Product Name Product Code Supplier Size Price
Bisucaberin
DatasheetThis may not be the latest data sheet.
14659 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS
Link

Bioactive Compounds

[Date : January 26 2021 23:29]

Bisucaberin


  • Product Code: 14659
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS
Link

Bioactive Compounds

Specification

Code No.14659
CAS#112972-60-8
Molecular FormulaC18H32N4O6
Molecular Weight400.476
SourceAlteromonas haloplankis SB-1123
AppearanceColorless crystal
Purity> 90% (HPLC)
Long Term Storageat - 20 °C
SolubilitySoluble in DMSO. Poorly soluble in MeOH.
Insoluble in H2O.

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Application Notes

Bisucaberin is a siderophore isolated from a culture broth of a marine bacterial strain identified as Alteromonas haloplanktis SB-1123.1,2) It inhibits the growth of fibrosarcoma 1023 (85% at 18 µg/ml), L1210 (IC50: 3.6 µg/ml) and IMC carcinoma (IC50: 5.1 µg/mL) without affecting their cell viability.1) (More than 98% of fibrosarcoma 1023 was viable with up to 18 µg/ml of bisucaberin.) Biscaberin induces macrophage-mediated tumor cell lysis (co-cultured with nonactivated macrophages).1) The Induced lysis is dependent on concentration of bisucaberin and reaches the maximum (specific lysis: ~70%) at 18 µg/ml. 1) Macrophages alone without bisucaberin or bisucaberin itself without macropharge induced little cytolysis of tumor cells at this concentration. Bisucaberin is considered to have its effect by sensitizing tumor cells to lysis by nonactivated macrophages and not by activating macrophages to be tumoricidal.1)

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References

1) Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. I. Taxonomy of the producing organism, isolation and biological properties. Kameyama T, et al. J Antibiot. 1987 40(12) 1664-1670.
2) Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. II. Physico- chemical properties and structure determination. Takahashi A, et al. J Antibiot. 1987 40(12) 1671-1676.


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