How to search

HOME> Products> Natural and Chemical compound> Bisucaberin

Antitumor Bisucaberin

Date：November 09 2020Web Page No：90002

Institute of Microbial Chemistry

Bisucaberin is a siderophore (iron-chelating compound) isolated from a culture broth of marine bacteria, Alteromonas haloplanktis SB-1123 1, 2).
Bisucaberin

Specification

CAS#112972-60-8
Molecular FormulaC18H32N4O6
Source Alteromonas haloplanktis SB-1123
Molecular Weight400.476
Purity>98% (HPLC)
SolubilitySoluble in DMSO. Poorly soluble in MeOH.
Insoluble in H2O.

Go back to index

Application Note

  • Bisucaberin inhibits the growth of fibrosarcoma 1023 (85% at 18 µg/ml), L1210 (IC50: 3.6 µg/ml) and IMC carcinoma (IC50: 5.1 µg/mL) without affecting their cell viability 1).
  • Biscaberin induces macrophage-mediated tumor cell lysis. The Induced lysis is dependent on concentration of bisucaberin and reaches the maximum (specific lysis: ~70%) at 18 µg/ml. Bisucaberin is considered to have its effect by sensitizing tumor cells to lysis by nonactivated macrophages and not by activating macrophages to be tumoricidal 1).


Go back to index

Reference

  1. Kameyama, T., et al., J. Antibiot., 40 (12), 1664～1670 (1987). [PMID:2962972]
  2. Takahashi, A., et al., J. Antibiot., 40 (12), 1671～1676 (1987). [PMID:2962973]

IMC banner

[Date : June 21 2025 00:11]

Detail Product Name Product Code Supplier Size Price
Bisucaberin, Antitumor
DatasheetThis may not be the latest data sheet. 		14659 IMCInstitute of Microbial Chemistry 1 mg $500

Description M.W. : 400.476　Purity : > 98% (HPLC)　Solubility : Soluble in DMSO, Slightly soluble in methanol, Insoluble in Water Bisucaberin is a siderophore isolated from a culture broth of a marine bacterial strain identified as Alteromonas haloplanktis. Bisucaberin induces macrophage-mediated tumor cell lysis (co-cultured with nonactivated macrophages.
Storage -20°C CAS 112972-60-8
Link

Bioactive Compounds

[Date : June 21 2025 00:11]

Bisucaberin, Antitumor

DatasheetThis may not be the latest data sheet.


  • Product Code: 14659
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description M.W. : 400.476　Purity : > 98% (HPLC)　Solubility : Soluble in DMSO, Slightly soluble in methanol, Insoluble in Water Bisucaberin is a siderophore isolated from a culture broth of a marine bacterial strain identified as Alteromonas haloplanktis. Bisucaberin induces macrophage-mediated tumor cell lysis (co-cultured with nonactivated macrophages.
Storage -20°C CAS 112972-60-8
Link

Bioactive Compounds

Go back to index

CONTACT

export@funakoshi.co.jp

  • ※Prices on our website are for your reference only. Please inquire your distributor for your prices.
  • ※Please note that Product Information or Price may change without notice.