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Inhibitory effect on MRSA and VRE Bottromycin A2

Date:July 03 2020Web Page No:520044

Bottromycin A2 is a natural product of bottromycins isolated and purified from Streptomyces.1)

Bottromycin A2 (Inhibitor for protein synthesis )

What is Bottromycin A2

Bottromycin A2 has a cyclic peptide structure and shows inhibitory activity against gram-positive bacteria. It is also reported to have low toxicity but strong antibacterial activity against drug-resistant bacteria, such as against MRSA(Methicillin-Resistant Staphylococcus Aureus) and VRE(Vancomycin-Resistant enterococci) 2),3) . The mechanism of Bottromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of ribosome and blocking aminoacyl-tRNA binding 4,5) . Its biosynthesis, total synthesis, derivative synthesis and their biological activities have also been studied, and several papers have been reported.


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Specification

CAS#15005-62-6
Molecular FormulaC42H62N8O7S
Molecular Weight823.067
SourceStreptomyces, No. 3668-L2
Purity>80% (HPLC)
SolubilitySoluble in MeOH, Ether and H2O
Insoluble in n-Hexane

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Application Note

Bottromycin A2 shows potent antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma.2,3) The mechanism of action of botromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of the ribosome and blocking aminoacyl-tRNA binding.4,5)

Biological activity by Bottromycin A2 3)
The value inside the parentheses is MIC (minimum inhibitory concentration).

  • S. aureus FDA209P (1 μg/ml)
  • S. aureus Smith (1 μg/ml)
  • MRSA HH-1 (1 μg/ml)
  • MRSA 92-1191 (2 μg/ml)
  • VRE NCTC12201 (1 μg/ml)
  • VRE NCTC12203 (0.5 μg/ml)

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Reference

  1. Nakamura S. et al. J. Antibiot., 18(1), 47~52(1965).
  2. Nakamura S. et al. J. Antibiot., 20(1), 1~5(1967).
  3. Kobayashi Y. et al. Bioorg. Med. Chem. Lett., 20(20), 6116~6120(2010).
  4. Otaka T. and Kaji A., J. Biol. Chem., 251(8), 2299~2306(1976).
  5. Lin Y.-C. et al. J. Antibiot., 21(8), 471~476(1968).
  6. Yamada T. et al. J. Org. Chem., 83(13), 7135~7149(2018).

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[Date : June 25 2024 00:08]

Detail Product Name Product Code Supplier Size Price
Bottromycin A2,Antibacterial (Gram-Positive)
DatasheetThis may not be the latest data sheet.
00592 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 15005-62-6
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Bioactive Compounds

[Date : June 25 2024 00:08]

Bottromycin A2,Antibacterial (Gram-Positive)


  • Product Code: 00592
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 15005-62-6
Link

Bioactive Compounds

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