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HOME> Products> Natural and Chemical compound> Bottromycin A2

Inhibitory effect on MRSA and VRE Bottromycin A2

Date：July 03 2020Web Page No：520044

Bottromycin A2 is a natural product of bottromycins isolated by Dr. Hamao Umezawa in Institute of Microbial Chemistry (Bikaken) and purified from Streptomyces.¹⁾

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* This product is for research use only.

Bottromycin A2 (Inhibitor for protein synthesis )

Chemical structure of Bottromycin A2 (#00592)

What is Bottromycin A2
Specification
Application Note
Reference

What is Bottromycin A2

Bottromycin A2 has a cyclic peptide structure and shows inhibitory activity against gram-positive bacteria. It is also reported to have low toxicity but strong antibacterial activity against drug-resistant bacteria, such as against MRSA(Methicillin-Resistant Staphylococcus Aureus) and VRE(Vancomycin-Resistant enterococci) ^2,3). The mechanism of Bottromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of ribosome and blocking aminoacyl-tRNA binding ^4,5). Its biosynthesis, total synthesis, derivative synthesis and their biological activities have also been studied, and several papers have been reported ^3,6).

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Specification

CAS#	15005-62-6
Molecular Formula	C₄₂H₆₂N₈O₇S
Molecular Weight	823.067
Source	Streptomyces, No. 3668-L2
Purity	>80% (HPLC)
Solubility	Soluble in MeOH, Ether and H₂O Insoluble in n-Hexane

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Application Note

Bottromycin A2 showed inhibitory activity against Xanthomonas oryzae pv., which causes white leaf blight in Oryza sativa oryzae, was active in vitro at an MIC of 2μg/ml ⁷⁾.
Bottromycin A2 shows potent antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma.^2,3) The mechanism of action of botromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of the ribosome and blocking aminoacyl-tRNA binding.^4,5)

Biological activity of Bottromycin A2 ³⁾
The value inside the parentheses is MIC (minimum inhibitory concentration).

Bacterial name	MIC (μg/ml)
S. aureus FDA209P	1
S. aureus Smith	1
MRSA HH-1	1
MRSA 92-1191	2
VRE NCTC12201	1
VRE NCTC12203	0.5

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Nakamura, S. et al., J. Antibiot., 18(1), 47-52(1965). [PMID:14282373]
Nakamura, S. et al., J. Antibiot., 20(1), 1-5(1967). [PMID:6072278]
Kobayashi, Y. et al., Bioorg. Med. Chem. Lett., 20(20), 6116-6120(2010). [PMID:20833545]
Otaka, T. and Kaji, A., J. Biol. Chem., 251(8), 2299-2306(1976). [PMID:770464]
Lin, Y.-C. et al., J. Antibiot., 21(8), 471-476(1968). [PMID:4884807]
Yamada, T. et al., J. Org. Chem., 83(13), 7135-7149(2018). [PMID:29560726]
Park, S.B. et al., J. Microbiol. Biotechnol., 21(12), 1236-1242(2011). [PMID:22210608]

[Date : May 19 2026 00:10]

Detail Product Name Product Code Supplier Size Price

Bottromycin A2, Antibacterial (Gram-Positive)
DatasheetThis may not be the latest data sheet. 00592 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 823.06 Purity : > 80％ (HPLC) Molecular Formula : C42H62N8O7S Solubility : Soluble in H2O, Methanol, and Ether, Insoluble in n-Hexane. Bottromycin A2 has a cyclic peptide structure and shows inhibitory activity against gram-positive bacteria. It is also reported to have low toxicity but strong antibacterial activity against drug-resistant bacteria, such as against MRSA(Methicillin-Resistant Staphylococcus Aureus) and VRE(Vancomycin-Resistant enterococci). The mechanism of Bottromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of ribosome and blocking aminoacyl-tRNA binding.
Storage	-20°C	CAS	15005-62-6
Link	Bioactive Compounds Natural macrocyclic compounds from microorganisms (such as cyclic peptides, and macrolides)

[Date : May 19 2026 00:10]

Bottromycin A2, Antibacterial (Gram-Positive)

DatasheetThis may not be the latest data sheet.

Product Code: 00592
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 823.06 Purity : > 80％ (HPLC) Molecular Formula : C42H62N8O7S Solubility : Soluble in H2O, Methanol, and Ether, Insoluble in n-Hexane. Bottromycin A2 has a cyclic peptide structure and shows inhibitory activity against gram-positive bacteria. It is also reported to have low toxicity but strong antibacterial activity against drug-resistant bacteria, such as against MRSA(Methicillin-Resistant Staphylococcus Aureus) and VRE(Vancomycin-Resistant enterococci). The mechanism of Bottromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of ribosome and blocking aminoacyl-tRNA binding.
Storage	-20°C	CAS	15005-62-6
Link	Bioactive Compounds Natural macrocyclic compounds from microorganisms (such as cyclic peptides, and macrolides)

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