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HOME> Products> Natural and Chemical compound> Bottromycin A2

Inhibitory effect on MRSA and VRE Bottromycin A2

Date：July 03 2020Web Page No：520044

Bottromycin A2 is a natural product of bottromycins isolated and purified from Streptomyces.¹⁾

Bottromycin A2 (Inhibitor for protein synthesis )

What is Bottromycin A2
Specification
Application Note
Reference

What is Bottromycin A2

Bottromycin A2 has a cyclic peptide structure and shows inhibitory activity against gram-positive bacteria. It is also reported to have low toxicity but strong antibacterial activity against drug-resistant bacteria, such as against MRSA(Methicillin-Resistant Staphylococcus Aureus) and VRE(Vancomycin-Resistant enterococci) ^2),3). The mechanism of Bottromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of ribosome and blocking aminoacyl-tRNA binding ^4,5). Its biosynthesis, total synthesis, derivative synthesis and their biological activities have also been studied, and several papers have been reported.

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Specification

CAS#	15005-62-6
Molecular Formula	C₄₂H₆₂N₈O₇S
Molecular Weight	823.067
Source	Streptomyces, No. 3668-L2
Purity	>80% (HPLC)
Solubility	Soluble in MeOH, Ether and H₂O Insoluble in n-Hexane

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Application Note

Bottromycin A2 shows potent antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma.^2,3) The mechanism of action of botromycin A2 is known to inhibit bacterial protein synthesis by binding to the A-site of the ribosome and blocking aminoacyl-tRNA binding.^4,5)

Biological activity by Bottromycin A2 ³⁾
The value inside the parentheses is MIC (minimum inhibitory concentration).

S. aureus FDA209P (1 μg/ml)
S. aureus Smith (1 μg/ml)
MRSA HH-1 (1 μg/ml)
MRSA 92-1191 (2 μg/ml)
VRE NCTC12201 (1 μg/ml)
VRE NCTC12203 (0.5 μg/ml)

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Reference

Nakamura S. et al. J. Antibiot., 18(1), 47～52(1965).
Nakamura S. et al. J. Antibiot., 20(1), 1～5(1967).
Kobayashi Y. et al. Bioorg. Med. Chem. Lett., 20(20), 6116～6120(2010).
Otaka T. and Kaji A., J. Biol. Chem., 251(8), 2299～2306(1976).
Lin Y.-C. et al. J. Antibiot., 21(8), 471～476(1968).
Yamada T. et al. J. Org. Chem., 83(13), 7135～7149(2018).

[Date : April 27 2024 00:06]

Detail Product Name Product Code Supplier Size Price

DatasheetThis may not be the latest data sheet. 00592 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS	15005-62-6
Link	Bioactive Compounds

[Date : April 27 2024 00:06]

DatasheetThis may not be the latest data sheet.

Product Code: 00592
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	15005-62-6
Link	Bioactive Compounds

Contact

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