Involved in inhibition of cancer metastasis Migrastatin

Migrastatin is a natural compound isolated from the culture fluid of actinomycetes and was first reported in 2000 ¹⁾. Several papers and patents have been published on its mechanism of action and its analogues.

• Specification
• Application Note
• Reference

Specification

• CAS# : 314245-65-3
• Molecular Formula : C27H39NO7
• Molecular Weight : 489.609
• Source : Streptomyces sp. MK929-43F1
• Purity : > 98% (HPLC)
• Solubility : Soluble in MeOH, DMSO and DMF. Insoluble in H2O.

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Application Note

• Inhibited metastasis of human esophageal cancer cells. No cytotoxicity or protein synthesis inhibition was observed ¹⁾
• Inhibited scaffold-independent growth of human small cell lung carcinoma (Ms-1) cells ²⁾
• Inhibition of cell proliferation ²⁾
  - Ms-1(human SCLC) IC₅₀ = 47 μg/ml (SCLC = Small Cell Lung Cancer)
  - HL-60 (human leukemia) IC₅₀ = 15 μg/ml
  - Jurkat (human T cell leukemia) IC₅₀ = 21 μg/ml
  - SW480 (human colon) IC₅₀ = 30 μg/ml
• Migrastatin analogues have also been studied and reported to inhibit cancer metastasis. ³⁾

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Reference

1. Nakae K. et al. J. Antibiot., 53(10), 1130-1136 (2000).
2. Takemoto Y. et al. J. Antibiot., 54(12), 1104-1107 (2001).
3. Giralt E. and Daniele L.R., Molecules, 22(2), 198/1-198/2 (2017).

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