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HOME> Products> Natural and Chemical compound> Rubratoxin A
HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Rubratoxin A

Inhibitor for Protein Phosphatase 2A (PP2A) Rubratoxin A

Date：February 24 2016Web Page No：80634

Institute of Microbial Chemistry

Rubratoxin A is a mycotoxin isolated from Penicillium sp.

Specification
Application Note
Reference

Specification

CAS#	22467-31-8
Molecular Formula	C₂₆H₃₂O₁₁
Molecular Weight	520.531
Source	Penicillium sp.
Purity	>95% (HPLC)
Solubility ※	Soluble in DMSO, Acetone, CH₃CN. Poorly soluble in Hexane

※ It is recommended to avoid using alcohol such as MeOH or EtOH which esterifies Rubratoxin A.

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Application Note

Rubratoxin A inhibits protein phosphatase 2A (PP2A) in a competitive manner (Ki: 28.7 nM, IC₅₀: 6.1-15.1 nM), however it does not inhibit protein phosphatases, such as PP1A and PP2B.
Rubratoxin A shows cytotoxicity in cultured mammalian cells (IC₅₀: around 15 µM) and induces overphosphorylation of PP2A substrate proteins.

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Reference

Wada, S., et al., Cancer Sci., 101 (3), 743～750 (2010). [PMID:20028386]

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Rubratoxin A,Protein Phosphatase 2A (PP2A) Inhibitor
DatasheetThis may not be the latest data sheet. 10663 IMCInstitute of Microbial Chemistry 1 mg $500

Contact

Description	Inhibitor for Protein Phosphatase 2A
Storage	4°C	CAS	22467-31-8
Link	Bioactive Compounds Natural compound Product List

[Date : February 15 2024 12:37]

Rubratoxin A,Protein Phosphatase 2A (PP2A) Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 10663
Supplier: IMC
Size: 1mg
Price: $500

Description	Inhibitor for Protein Phosphatase 2A
Storage	4°C	CAS	22467-31-8
Link	Bioactive Compounds Natural compound Product List

Contact

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CONTACT

export@funakoshi.co.jp

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