TNF-alpha 組換え体(リコンビナント)タンパク質 | Recombinant Human TNF-alpha
掲載日情報：2015/01/26 現在Webページ番号：111949
R&D Systems社製の高品質なTNF-alphaの組換え体タンパク質(Recombinant Human TNF-alpha)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 00時00分現在]
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[在庫・価格 ：2025年04月26日 00時00分現在]
Recombinant Human TNF-alpha
文献数： 664
- 商品コード：210-TA-005
- メーカー：RSD
- 包装：5μg
- 価格：¥27,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：17.5 kDa，Genbank：7124，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：E. coli 別名：APC1 protein Genbank No： 7124 Protein Accession No： P01375 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | -20℃ | 法規備考 | |||||
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| 製品記事 | 組換え体TNF-α 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies SEC-MALS分析済みの組換えタンパク質（R&D Systems） |
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Recombinant Human TNF-alpha, CF
文献数： 0
- 商品コード：210-TA-005/CF
- メーカー：RSD
- 包装：5μg
- 価格：¥27,000
- 在庫：2個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：17.5 kDa，Genbank：7124，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：E. coli 別名：APC1 protein Genbank No： 7124 Protein Accession No： P01375 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
ニュース2025年3月15日号 p.17
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| 製品記事 | Proteome Profiler Human Ubiquitin Array Kit 組換え体TNF-α 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies ユビキチン・プロテアソーム特集 SEC-MALS分析済みの組換えタンパク質（R&D Systems） |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Val77-Leu233, with and without an N-terminal Met
- Accession
- P01375
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 17.5 kDa
- SDS-PAGE
- 17 kDa, reducing conditions
- Activity
- Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds)
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Additional Information
- Molecule Information
- TNF-alpha
- Aliases
- Cachetin; DIF; TNF; tnfa; tnf-a; TNFSF1A; TNFSF2
- Entrez Gene IDs
- 7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit)
- Background
- TNF-alpha Background
- Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
In vivo modulation of the inflammatory response by nonsteroidal antiinflammatory drug-related compounds that trigger L-selectin shedding.
Arce-Franco M, Barreiro O, Diaz-Gonzalez F, Dominguez-Luis M, Feria M, Herrera-Garcia A, Lopez-Fernandez J, Sanchez-Madrid F
Eur J Immunol 2013 43:55-64
Species: Human
Protein Application: Bioassay
Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
Bernabeu C, Blanco F, Botella L, Cabanas C, Duwell A, Eleno N, Langa C, Lopez-Novoa J, Rossi E, Sanz-Rodriguez F
Blood 2013 121:403-15
Species:
Protein Application: Bioassay
Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation.
Al-Attar P, Chen C, Dawes S, Diaconu D, Fritz Y, Fu W, Gudjonsson J, Guzman A, Johnston A, McCormick T, Ward N
J Immunol 2013 190:2252-62
Species: Human
Protein Application: Bioassay
Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice.
Akgul Y, Keller P, Kishore A, Mogami H, Shi H, Word R
J Biol Chem 2013 288:1953-66
Species: Human
Protein Application: Media Supplement - Cell Prep
Kinome-wide functional genomics screen reveals a novel mechanism of TNF??-induced nuclear accumulation of the HIF-1?? transcription factor in cancer cells.
Brown DD, Fedorov Y, Schoolmeesters A
PLoS ONE 2012 7:e31270
Species: Human
Protein Application: Bioassay
Daily exposure to dust alters innate immunity.
Larsson K, Palmberg L, Sahlander K
PLoS ONE 2012 7:e31646
Species: Human
Protein Application: Bioassay
Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Bellati F, Belleudi F, Clausen H, Frati L, Irimura T, Napoletano C, Nuti M, Pierelli L, Rahimi H, Rughetti A, Wandall HH, Zizzari IG
Eur. J. Immunol. 2012 42:936-45
Species: Human
Protein Application: Bioassay
Constitutive expression of inter-alpha-inhibitor (IalphaI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex.
Day AJ, He H, Tseng SC, Zhang S
J. Biol. Chem. 2012 287:12433-44
Species: Human
Protein Application: Bioassay
The SDF-1??/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
Hao E, Hayek A, Hinton A, Kayali AG, King CC, Lopez AD
PLoS ONE 2012 7:e38721
Species: Human
Protein Application: Bioassay
Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Chakir J, Gounni AS, Halayko AJ, Koussih L, Redhu NS, Shan L, Zhang J
PLoS ONE 2012 7:e34965
Species: Human
Protein Application: Bioassay
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