TNF-alpha 組換え体(リコンビナント)タンパク質 | Recombinant Human TNF-alpha

掲載日情報:2015/01/26 現在Webページ番号:111949

R&D Systems社製の高品質なTNF-alphaの組換え体タンパク質(Recombinant Human TNF-alpha)です。
本製品は研究用です。研究用以外には使用できません。

[在庫・価格 :2024年03月28日 17時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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納期 文献数
Recombinant Human TNF-alpha
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 664
説明文
純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.,由来動物:Human,M.W.:17.5 kDa,Genbank:7124,エンドトキシンレベル:<0.10 EU per 1 µg of the protein by the LAL method.,産生:E. coli
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P01375
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
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製品記事 組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
SEC-MALS分析済みの組換えタンパク質(R&D Systems)
関連記事
Recombinant Human TNF-alpha, CF
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 0
説明文
純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.,由来動物:Human,M.W.:17.5 kDa,Genbank:7124,エンドトキシンレベル:<0.10 EU per 1 µg of the protein by the LAL method.,産生:E. coli
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P01375
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 Proteome Profiler Human Ubiquitin Array Kit
組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
ユビキチン・プロテアソーム特集
SEC-MALS分析済みの組換えタンパク質(R&D Systems)
関連記事

[在庫・価格 :2024年03月28日 17時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Recombinant Human TNF-alpha

文献数: 664

説明文 純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.,由来動物:Human,M.W.:17.5 kDa,Genbank:7124,エンドトキシンレベル:<0.10 EU per 1 µg of the protein by the LAL method.,産生:E. coli
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P01375
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
SEC-MALS分析済みの組換えタンパク質(R&D Systems)
関連記事

Recombinant Human TNF-alpha, CF

文献数: 0

説明文 純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.,由来動物:Human,M.W.:17.5 kDa,Genbank:7124,エンドトキシンレベル:<0.10 EU per 1 µg of the protein by the LAL method.,産生:E. coli
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P01375
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 Proteome Profiler Human Ubiquitin Array Kit
組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
ユビキチン・プロテアソーム特集
SEC-MALS分析済みの組換えタンパク質(R&D Systems)
関連記事

バルク注文に関して

バルク包装品も承ります。お気軽にお問合せ下さい。

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CF(Carrier-Free)とは?

R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。

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Product Details

Source
E. coli-derived, Val77-Leu233, with and without an N-terminal Met
Accession
P01375
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Predicted Molecular Mass
17.5 kDa
SDS-PAGE
17 kDa, reducing conditions
Activity
Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds)

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Additional Information

Molecule Information
TNF-alpha
Aliases
Cachetin; DIF; TNF; tnfa; tnf-a; TNFSF1A; TNFSF2
Entrez Gene IDs
7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit)
Background
TNF-alpha Background
Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

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Citations

Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.

In vivo modulation of the inflammatory response by nonsteroidal antiinflammatory drug-related compounds that trigger L-selectin shedding.
Arce-Franco M, Barreiro O, Diaz-Gonzalez F, Dominguez-Luis M, Feria M, Herrera-Garcia A, Lopez-Fernandez J, Sanchez-Madrid F
Eur J Immunol 2013 43:55-64
Species: Human
Protein Application: Bioassay


Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
Bernabeu C, Blanco F, Botella L, Cabanas C, Duwell A, Eleno N, Langa C, Lopez-Novoa J, Rossi E, Sanz-Rodriguez F
Blood 2013 121:403-15
Species:
Protein Application: Bioassay


Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation.
Al-Attar P, Chen C, Dawes S, Diaconu D, Fritz Y, Fu W, Gudjonsson J, Guzman A, Johnston A, McCormick T, Ward N
J Immunol 2013 190:2252-62
Species: Human
Protein Application: Bioassay


Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice.
Akgul Y, Keller P, Kishore A, Mogami H, Shi H, Word R
J Biol Chem 2013 288:1953-66
Species: Human
Protein Application: Media Supplement - Cell Prep


Kinome-wide functional genomics screen reveals a novel mechanism of TNF??-induced nuclear accumulation of the HIF-1?? transcription factor in cancer cells.
Brown DD, Fedorov Y, Schoolmeesters A
PLoS ONE 2012 7:e31270
Species: Human
Protein Application: Bioassay


Daily exposure to dust alters innate immunity.
Larsson K, Palmberg L, Sahlander K
PLoS ONE 2012 7:e31646
Species: Human
Protein Application: Bioassay


Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Bellati F, Belleudi F, Clausen H, Frati L, Irimura T, Napoletano C, Nuti M, Pierelli L, Rahimi H, Rughetti A, Wandall HH, Zizzari IG
Eur. J. Immunol. 2012 42:936-45
Species: Human
Protein Application: Bioassay


Constitutive expression of inter-alpha-inhibitor (IalphaI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex.
Day AJ, He H, Tseng SC, Zhang S
J. Biol. Chem. 2012 287:12433-44
Species: Human
Protein Application: Bioassay


The SDF-1??/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
Hao E, Hayek A, Hinton A, Kayali AG, King CC, Lopez AD
PLoS ONE 2012 7:e38721
Species: Human
Protein Application: Bioassay


Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Chakir J, Gounni AS, Halayko AJ, Koussih L, Redhu NS, Shan L, Zhang J
PLoS ONE 2012 7:e34965
Species: Human
Protein Application: Bioassay


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