Trehalose Analogues Resistant to Various Microorganisms and Trehalase Lentztrehalose A and its analogues B, C

Lentztrehalose A, B, C are trehalose analogues isolated from the soilid-state culture of Lentzea sp. ML457-mF8. Unlike trehalose, these lentztrehalose are stable to porcine kidney trehalase and not broken down by various microorganisms that metabolize trehalose.

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Lentztrehalose A, B, C or trehalose were added to the seven bacterial cultures, and the culture was incubated. Although trehalose was degraded and reduced, lentztrehaloses showed little degradation.

Lentztrehalose A-C and trehalose were reacted with porcine kidney trehalase and the concentrations of released glucose were determined by a hexokinase assay. Lentztrehalose A-C showed no degradation and high stability against trehalose-degrading enzymes.

The blood kinetics of administered compounds are important for showing their activity in vivo. When mice were orally administered Lentztrehalose A-C, their blood levels increased significantly compared to trehalose.

Tumor growth results in ICR mice bearing sarcoma 180 tumor cells administered orally(P.O.) or intravenous injection(I.V.) with 50 mg/kg of lentztrehalose A, trehalose or physiological saline(control) on the date indicated as ⮝.

Tumor growth results in ICR mice bearing S-180 sarcoma cells administered orally(P.O.) or intravenous injection(I.V.) at 50 mg/kg of Lentztrehalose A, Trehalose or physiological saline(control) on the date indicated as ⮝.

- Lentztrehalose A, B & C

- Lentztrehalose A