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HOME> Products> Natural and Chemical compound> Other natural compound> Bactobolin A (hydrochloride)

Natural compounds harboring both antibiotic and anti-tumor activities Bactobolin A (hydrochloride)

Date：May 15 2025Web Page No：520080

Bactobolin A was isolated from the fermentation broth of Pseudomonas sp. BMG13-A7. This bioactive compound has broad-spectrum antibacterial activity^1） and prolongs the survival period of mice bearing leukemia L1210. ^2）
It is reported that bactobolin A binds to a site on the 70S ribosome, which was different from the other antibiotics previously known. ^3）
※Synthetic derivative, Bactobolamine, is also available.
BactobolinA-HCl-Structure

Structure of Bactobolin A (hydrochloride) (#08465)

Specification
Application Note
Reference

Specification

CAS No.: 72615-20-4（This CAS No. is for salt free form, shown as reference information.）^＊
Molecular Formula: C₁₄H₂₀Cl₂N₂O₆･HCl (mono HCl salt)
Molecular Weight: 419.680 (mono HCl salt)
Purity: >95% (HPLC)
Solubility: Soluble in DMSO and H₂O

＊ Our bactobolin A is supplied as the hydrochloride salt form of which a CAS number has not been given yet.

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Application Note

Bactobolin A prolonged the survival period of CDF1 mice bearing a mouse lymphocytic leukemia L1210 cell line via intraperitoneal administration of the bioactive compound as 0.15~2.5 mg/kg/day for 10 days.^2）

      Maximum tolerated dose: 2.5 mg/kg/day
      Optimal dose: 0.6 mg/kg/day
      Minimum effective dose: 0.15 mg/kg/day
The acute toxicity of bactobolin A is estimated at 6.25~12.5 mg/kg in mice by a single intraperitoneal injection.

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Reference

Kondo, S., et al., J. Antibiotics, 32 (10), 1069～1071 (1979). [PMID:528370]
Ishizuka, M., et al., J. Antibiotics, 33 (9), 1054～1062 (1980). [PMID:7440410]
Amunts, A., et al., J. Mol. Biol., 427 (4), 753～755 (2015). [PMID:25562208]

[Date : May 16 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Bactobolin A (hydrochloride), Antitumor, Antibacterial
DatasheetThis may not be the latest data sheet. 08465 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 419.680 (hydrochloride form) Purity : >95％ (HPLC) Molecular Formula : C14H20Cl2N2O6･HCl (hydrochloride form) Solubility : Soluble in H2O, DMSO, Bactobolin A is supplied as hydrochloride form. This bioactive compound has broad-spectrum antibacterial, antitumor, and antileukemia activities. It prolongs the survival period of mice bearing a mouse lymphocytic leukemia L1210 cell line. It is reported that bactobolin A binds to a site on the 70S ribosome.
Storage	-20°C	CAS	72615-20-4 (salt free form)
Link	Bioactive Compounds

[Date : May 16 2025 00:07]

Bactobolin A (hydrochloride), Antitumor, Antibacterial

DatasheetThis may not be the latest data sheet.

Product Code: 08465
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 419.680 (hydrochloride form) Purity : >95％ (HPLC) Molecular Formula : C14H20Cl2N2O6･HCl (hydrochloride form) Solubility : Soluble in H2O, DMSO, Bactobolin A is supplied as hydrochloride form. This bioactive compound has broad-spectrum antibacterial, antitumor, and antileukemia activities. It prolongs the survival period of mice bearing a mouse lymphocytic leukemia L1210 cell line. It is reported that bactobolin A binds to a site on the 70S ribosome.
Storage	-20°C	CAS	72615-20-4 (salt free form)
Link	Bioactive Compounds

Contact

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