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HOME> Products> Natural and Chemical compound> Other natural compound> Bactobolamine

Immunosuppressant Bactobolamine

Date：May 15 2025Web Page No：520079

Bactobolamine (BBL) is a synthetic derivative of a metabolite of bactobolin A from Pseudomonas genus.¹⁾ Bactobolamine suppresses proliferative lymphocytic responses such as concanavalin A induced lymphoblast formation, and it induces significant prolongation of allograft survival.²⁾ Low-dose combination of bactoblamine and tacrorimus (FK506) prolongs markedly the survival of rat liver allografts. It was also reported that low-dose combination of bactobolamine and cyclosporine A (CyA) inhibits human mixed-lymphocyte reaction (MLR).³⁾

Bactobolamine-Structure

Structure of Bactobolamine (#15160)

Specification
Application Note
Reference

Specification

CAS#: 78013-07-7
Molecular Formula: C₁₁H₁₅Cl₂NO₅
Molecular Weight: 312.143
Purifty: >98% (HPLC)
Solubility: Soluble in DMSO and H₂O

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Application Note

Bactobolamine suppresses lymphocyte proliferation such as concanavaline A-induced lymphocyte proliferation and induces significant prolongation of allograft survival.^2）
Low-dose combination of bactoblamine and tacrorimus (FK506) prolongs markedly the survival of rat liver allografts.^3）
Low-dose combination of bactobolamine and cyclosporine A (CyA) inhibits human mixed-lymphocyte reaction (MLR).^3）

		CyA Conc.
		0 ng/ml	1 ng/ml	10 ng/ml
BBL Conc.	0 μg/ml	ー	0.09±13.4	5.00±13.4
	10 μg/ml	9.23±2.90	22.7±9.94	25.8±10.0
	20 μg/ml	6.58±2.74	23.2±6.58	36.8±5.75

Degree of inhibition against human mixed-lymphocyte reaction (MLR)
by utilizing combination of Bactobolamine (BBL) and Cyclosporine A (CyA)
The numbers shown on the table are Percent Inhibition (Mean±SE)

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Reference

Munakata, T., Yakugaku Zasshi, 101 (2), 138～147 (1981). [PMID:7288570]
Tomikawa, S., et al., Transplant. Proc., 29 (1-2), 1276～1278 (1997). [PMID:9123304]
Imai, T., et al., Transplant. Proc., 32 (7), 2060～2062 (2000). [PMID:11120066]

[Date : May 16 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Bactobolamine, Immunosuppressant
DatasheetThis may not be the latest data sheet. 15160 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 312.143 Purity : >98％ (HPLC) Molecular Formula : C11H15Cl2NO5 Solubility : Soluble in H2O, DMSO, Bactobolamine suppresses proliferative lymphocytic responses such as concanavalin A induced lymphoblast formation. Low-dose combination of bactobolamine and cyclosporine A (CyA) inhibits human mixed-lymphocyte reaction (MLR).
Storage	-20°C	CAS	78013-07-7
Link

[Date : May 16 2025 00:07]

Bactobolamine, Immunosuppressant

DatasheetThis may not be the latest data sheet.

Product Code: 15160
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 312.143 Purity : >98％ (HPLC) Molecular Formula : C11H15Cl2NO5 Solubility : Soluble in H2O, DMSO, Bactobolamine suppresses proliferative lymphocytic responses such as concanavalin A induced lymphoblast formation. Low-dose combination of bactobolamine and cyclosporine A (CyA) inhibits human mixed-lymphocyte reaction (MLR).
Storage	-20°C	CAS	78013-07-7
Link

Contact

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