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Dipeptidyl Aminopeptidase Inhibitor and Aflatoxin Production Inhibitor Dioctatin A (Hydrochloride)

Date：May 15 2023Web Page No：520062

Dioctatin A was reported as a compound that selectively inhibits DPP2 (dipeptidyl aminopeptidase II) from rat spleen ^1,2). And, Dioctatin A has been reported to inhibit aflatoxin production by Aspergillus parasiticus known as aflatoxin-producing fungus, and has potential applications in contamination control against mycotoxin ³⁾. Dioctatin, a synthetic devinyl derivative of dioctatin A, also inhibits aflatoxin production in A. parasiticus, and the target of dioctatin is mitochondrial protease Clp (Chaperonin-linked-protease). The inhibiton mechanism is reported to be that dioctatin-bound ClpP selectively degraded mitochondrial energy-related proteins, including a subunit of respiratory chain complex V ⁴⁾.

Dioctatin-A-Structure

DASH Proteins & DPP2
Specification
Application Note
Reference
Product Information

DASH Proteins & DPP2

Various subtypes of proline-selective dipeptidyl peptidase (DPP) have been reported, especially DPP4 inhibitors are used for antidiabetic drugs.
Among DPPs, DPP2, DPP4, DPP8, DPP9, and FAP (fibroblast activation protein α) are also called DPP4 Activity and/or Structure Homologue (DASH) proteins ⁵⁾.
Inhibition or silencing of DPP2, also known as DPP7, has been reported to induce apoptosis of lymphocytes in G₀ phase, quiescence stage. Changes in DPP2 activity levels have been observed in many disease states, including autoimmune diseases such as Sjögren's syndrome, rheumatoid arthritis (RA) and lupus erythematosus, Parkinson's disease, neurodegenerative disorders, myopathy, cancer and gastrointestinal disorders ^6,7), and there is interest in the relationship between these diseases and DPP2 function.

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Specification

CAS#	138146-67-5 (salt free form)
Molecular Formula	C₂₁H₃₉N₃O₄ HCl (mono HCl salt)
Molecular Weight	434.018 (mono HCl salt)
Source	Streptomyces sp.
Purity	> 95% (HPLC)
Solubility	Soluble in acidic DMSO, acidic water, acidic MeOH

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Application Note

Inhibits dipeptidyl aminopeptidase II selectively (IC₅₀: 0.19 μg/ml, rat pancreas)
Inhibits aflatoxin production in Aspergillus parasiticus (IC₅₀: 4.0 μM)

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Reference

Takeuchi, T., et al., Japanese Patent, JP03077857 A1 (1991).
Sakuda, S., et al., US Patent, US2010/0063150 A1 (2010).
Yoshinari, T., et al., Microbiology, 153 (8), 2774～2780 (2007). [PMID:17660441]
Furukawa, T., et al., Cell Chem. Biol., 27 (11), 1396～1409 (2020). [PMID:32888498]
De Meester, I., Handbook of Proteolytic Enzymes (Third Edition), Chapter 759, p.3432, (2013), Edited by Rawlings, N.D., et al., Elsevier
Waumans, Y., et al., Front. Immunol., 6. 387 (2015). [PMID:26300881]
Wagner, L., et al., Clin. Exp. Immunol., 184 (3), 265～283 (2016). [PMID:26671446]

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Product Information

[Date : May 06 2024 00:05]

Detail Product Name Product Code Supplier Size Price

Dioctatin A (Hydrochloride), Human Dipeptidyl Aminopeptidase II Inhibitor, Aflatoxin Production Inhibitor
DatasheetThis may not be the latest data sheet. 14700 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS	138146-67-5 (salt free form)
Link	Bioactive Compounds

[Date : May 06 2024 00:05]

Dioctatin A (Hydrochloride), Human Dipeptidyl Aminopeptidase II Inhibitor, Aflatoxin Production Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 14700
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	138146-67-5 (salt free form)
Link	Bioactive Compounds

Contact

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