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Anti-Tumor Activity Altemicidin

Date:July 03 2020Web Page No:520049

Altemicidin was firstly found in the culture medium of Streptomyces sioyaensis, SA-17588 1,2) , and it shows antitumor activity. Altemicidin analogues with isoleucyl tRNA synthetase inhibitory activity have been found from streptomyces3), and the synthesis4) and biosynthesis5) of these analogues are being studied.

Altemicidin

Specification

CAS#125399-82-8
Molecular FormulaC13H20N4O7S
SourceStreptomyces sp. MI944-61F6
Molecular Weight376.384
Purity> 90% (HPLC)
SolubilitySoluble in H2O. Poorly soluble in MeOH.
Insoluble in acetone, hexane.

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Application Note

  • Altemicidin inhibited the growth of murine leukemia L1210 (IC50: 0.84 μg/mL) and IMC carcinoma cells (IC50: 0.82 μg/mL).1)
  • Altemicidin showed inhibitory activity against Xanthomonas oryzae (MIC: 6.25 μg/mL).1)
  • LC50 against brine shrimp was 3.0 μg/mL.1)
  • Altemicidin showed 50% prevention value against two-spotted spider mites on kidney bean leaves at about 10 ppm.1)

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Reference

  1. Takahashi A. et al. J. Antibiot., 42(11), 1556-1561 (1989).
  2. Takahashi A. et al. J. Antibiot., 42(11), 1562-1566 (1989).
  3. Stefanska A. L. et al. J. Antibiot., 53(4), 357-363 (2000).
  4. Hayakawa I. et al. J. Org. Chem., 84(23), 15614-15623 (2019).
  5. Hu Z. et al. Nature Commun., 10(1), 1-10 (2019).

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[Date : July 15 2024 00:05]

Detail Product Name Product Code Supplier Size Price
Altemicidin,Acaricidal and Antitumor
DatasheetThis may not be the latest data sheet.
12151 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 125399-82-8
Link

Bioactive Compounds

[Date : July 15 2024 00:05]

Altemicidin,Acaricidal and Antitumor


  • Product Code: 12151
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 125399-82-8
Link

Bioactive Compounds

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