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HOME> Products> Natural and Chemical compound> Altemicidin

Anti-Tumor Activity Altemicidin

Date：July 03 2020Web Page No：520049

Altemicidin was firstly found in the culture medium of Streptomyces sioyaensis, SA-17588^1,2) , and it shows antitumor activity. Altemicidin analogues with isoleucyl tRNA synthetase inhibitory activity have been found from streptomyces³⁾, and the synthesis⁴⁾ and biosynthesis⁵⁾ of these analogues are being studied.

Specification
Application Note
Reference

Specification

CAS#	125399-82-8
Molecular Formula	C₁₃H₂0N₄O₇S
Source	Streptomyces sp. MI944-61F6
Molecular Weight	376.384
Purity	> 90% (HPLC)
Solubility	Soluble in H₂O. Poorly soluble in MeOH. Insoluble in acetone, hexane.

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Application Note

Altemicidin inhibited the growth of murine leukemia L1210 (IC₅₀: 0.84 μg/mL) and IMC carcinoma cells (IC₅₀: 0.82 μg/mL).¹⁾
Altemicidin showed inhibitory activity against Xanthomonas oryzae (MIC: 6.25 μg/mL).¹⁾
LC₅₀ against brine shrimp was 3.0 μg/mL.¹⁾
Altemicidin showed 50% prevention value against two-spotted spider mites on kidney bean leaves at about 10 ppm.¹⁾

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Reference

Takahashi A. et al. J. Antibiot., 42(11), 1556-1561 (1989).
Takahashi A. et al. J. Antibiot., 42(11), 1562-1566 (1989).
Stefanska A. L. et al. J. Antibiot., 53(4), 357-363 (2000).
Hayakawa I. et al. J. Org. Chem., 84(23), 15614-15623 (2019).
Hu Z. et al. Nature Commun., 10(1), 1-10 (2019).

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Altemicidin,Acaricidal and Antitumor
DatasheetThis may not be the latest data sheet. 12151 IMCInstitute of Microbial Chemistry 1 mg $500

Contact

Description
Storage	-20°C	CAS	125399-82-8
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Altemicidin,Acaricidal and Antitumor

DatasheetThis may not be the latest data sheet.

Product Code: 12151
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	125399-82-8
Link	Bioactive Compounds

Contact

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