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HOME> Products> Natural and Chemical compound> Benanomicin B

Anti-HIV and anti-fungal activity Benanomicin B

Date：July 03 2020Web Page No：520047

Benanomicin B is an antibiotic isolated from the culture fluid of Actinomadura sp. MH193-16F4.^1,2)
Benanomicin B prevented human T-cells from HIV-1 at 10~100 µg/mL and inhibited syncytium formation by HIV-1 at 10~100 µg/mL.³⁾ The antifungal and anti HIV-1 activities of benanomicins and their analogues have been studied.⁴⁾ It also showed good antibacterial activity against Candida, Cryptococcus and Saccharomyces, etc.

Specification
Application Note
Reference

Specification

CAS#	116249-66-2
Molecular Formula	C₃₉H₄₂N₂O₁₈
Molecular Weight	826.761
Source	Actinomadura sp. MH193-16F4
Purity	> 90% (HPLC)
Long Term Storage	at - 20 °C
Solubility	Soluble in DMSO. Insoluble in H₂O.

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Application Note

Exhibited the following antimicrobial activity(MIC) ^1,4):
Cryptococcus neoformans F-10 1.56 μg/ml, Candida pseudotropicalis F-2 6.25 μg/mL, Candida kusei F-5 6.25 μg/ml, Candida sp. Yu-1200 6.25 μg/ml, Saccharomyces cerevisiae F-7 6.25 μg/ml
Inhibited infection of human T-cells with human immunodeficiency virus (HIV-1) at 10~100 µg/mL.³⁾

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Reference

Takeuchi T. et al. J. Antibiot., 41(6), 807～811 (1988).
Gomi S. et al. J. Antibiot., 41(8), 1019～1028 (1988).
Hoshino H. et al. J. Antibiot., 42(2), 344～346 (1989).
Kondo S. et al. J. Antibiot., 44(11), 1228～1236 (1991).

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Benanomicin B,Antifungal
DatasheetThis may not be the latest data sheet. 02968 IMCInstitute of Microbial Chemistry 1 mg $500

Contact

Description
Storage	-20°C	CAS	116249-66-2 (free form)
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Benanomicin B,Antifungal

DatasheetThis may not be the latest data sheet.

Product Code: 02968
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	116249-66-2 (free form)
Link	Bioactive Compounds

Contact

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