Antifungal activity and significant efficacy against a Pneumocystis carinii infected mouse model Benanomicin A
Date:July 03 2020Web Page No:520046
Benanomicin A is isolated from the culture fluid of Actinomadura sp. MH193-16F4.1,2) It shows excellent activities against a wide range of fungi including Candida, Cryptococcus and Aspergillus.1,3) Also, benanomicin A demonstrated excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model.4) Moreorver, benanomicin A prevented human T-cells from HIV-1 at 30-100 µg/mL and inhibited syncytium formation by HIV-1 at 10-100 µg/mL.5)
The antifungal and anti HIV-1 activities of benanomicins and their analogues have been studied.6) Benanomicin A has antimycotic activities via binding to mannan in the cell walls of fungi.7) In recent years, the lectin-like functionality of Benanomicin A has been utilized to conduct research on preparing the mannan cell walls.8,9)

Specification
CAS# | 116249-65-1 |
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Molecular Formula | C39H41NO19 |
Molecular Weight | 827.745 |
Source | Actinomadura sp. MH193-16F4 |
Purity | > 90% (HPLC) |
Solubility | Soluble in DMSO and DMF. Poorly soluble in MeOH and CHCl3 Insoluble in H2O |
Application Note
- Exhibited the following antimicrobial activity(MIC) 3):
Cryptococcus neoformans 0.63-1.25 μg/ml, Cryptococcus laurenti 0.63 μg/ml, Cryptococcus terreus 0.63 μg/ml, Rhodotorula rubra 0.63 μg/ml, Trichosporon cutaneum 1.25-5.0 μg/ml - Benanomicin A at 12.5 mg/L (MIC) killed 99.7% of Candida albicans cells at 2 h.3)
- 10 mg/kg/day of Benanomicin A was effective against Pneumocystis carinii pneumonia infection in the mice.4)
- Benanomicin A was well tolerated by experimental animals; mice, rats and dogs were given intravenous doses of 600 mg/kg and rats were given 100 mg/kg per day for 28 days.3)
Reference
- Takeuchi T. et al. J. Antibiot., 41(6), 807~811 (1988).
- Gomi S. et al. J. Antibiot., 41(8), 1019~1028 (1988).
- Watanabe M. et al. J. Antimicrob. Chemother., 38, 1073~1077 (1996).
- Yasuoka A. et al. Antimicrob. Agents Chemother., 39(3), 720~724 (1995).
- Hoshino H. et al. J. Antibiot., 42(2), 344~346 (1989).
- Kondo S. et al. J. Antibiot., 44(11), 1228~1236 (1991).
- Watanabe M. et al. J. Antibiot., 49(4), 366~373 (1996).
- Kuraoka T. et al. FEBS Open Bio, 9, 129~136 (2019).
- Kuraoka T. et al. Int. J. Curr. Microbiol. Appl. Sci., 8(1), 2926~2935 (2019).

[Date : April 25 2025 00:06]
Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
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Benanomicin A, Antifungal via Binding to Mannan DatasheetThis may not be the latest data sheet. |
02966 | IMCInstitute of Microbial Chemistry | 1 mg | $500 | |||||||||||||||||||||||||||||||
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[Date : April 25 2025 00:06]
Benanomicin A, Antifungal via Binding to Mannan
DatasheetThis may not be the latest data sheet.
- Product Code: 02966
- Supplier: IMC
- Size: 1mg
- Price: $500
Description | |||
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Storage | -20°C | CAS | 116249-65-1 |
Link |
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