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HOME> Products> Natural and Chemical compound> Benanomicin A

Antifungal activity and significant efficacy against a Pneumocystis carinii infected mouse model Benanomicin A

Date：July 03 2020Web Page No：520046

Benanomicin A is isolated from the culture fluid of Actinomadura sp. MH193-16F4.^1,2) It shows excellent activities against a wide range of fungi including Candida, Cryptococcus and Aspergillus.^1,3) Also, benanomicin A demonstrated excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model.⁴⁾ Moreorver, benanomicin A prevented human T-cells from HIV-1 at 30-100 µg/mL and inhibited syncytium formation by HIV-1 at 10-100 µg/mL.⁵⁾
The antifungal and anti HIV-1 activities of benanomicins and their analogues have been studied.⁶⁾ Benanomicin A has antimycotic activities via binding to mannan in the cell walls of fungi.⁷⁾ In recent years, the lectin-like functionality of Benanomicin A has been utilized to conduct research on preparing the mannan cell walls.^8,9)

Specification
Application Note
Reference

Specification

CAS#	116249-65-1
Molecular Formula	C₃₉H₄₁NO₁₉
Molecular Weight	827.745
Source	Actinomadura sp. MH193-16F4
Purity	> 90% (HPLC)
Solubility	Soluble in DMSO and DMF. Poorly soluble in MeOH and CHCl₃ Insoluble in H₂O

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Application Note

Exhibited the following antimicrobial activity(MIC) ³⁾:
Cryptococcus neoformans 0.63-1.25 μg/ml, Cryptococcus laurenti 0.63 μg/ml, Cryptococcus terreus 0.63 μg/ml, Rhodotorula rubra 0.63 μg/ml, Trichosporon cutaneum 1.25-5.0 μg/ml
Benanomicin A at 12.5 mg/L (MIC) killed 99.7% of Candida albicans cells at 2 h.³⁾
10 mg/kg/day of Benanomicin A was effective against Pneumocystis carinii pneumonia infection in the mice.⁴⁾
Benanomicin A was well tolerated by experimental animals; mice, rats and dogs were given intravenous doses of 600 mg/kg and rats were given 100 mg/kg per day for 28 days.³⁾

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Reference

Takeuchi T. et al. J. Antibiot., 41(6), 807～811 (1988).
Gomi S. et al. J. Antibiot., 41(8), 1019～1028 (1988).
Watanabe M. et al. J. Antimicrob. Chemother., 38, 1073～1077 (1996).
Yasuoka A. et al. Antimicrob. Agents Chemother., 39(3), 720～724 (1995).
Hoshino H. et al. J. Antibiot., 42(2), 344～346 (1989).
Kondo S. et al. J. Antibiot., 44(11), 1228～1236 (1991).
Watanabe M. et al. J. Antibiot., 49(4), 366～373 (1996).
Kuraoka T. et al. FEBS Open Bio, 9, 129～136 (2019).
Kuraoka T. et al. Int. J. Curr. Microbiol. Appl. Sci., 8(1), 2926～2935 (2019).

[Date : May 16 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Benanomicin A, Antifungal via Binding to Mannan
DatasheetThis may not be the latest data sheet. 02966 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 827.74 Purity : > 90％ (HPLC) Molecular Formula : C39H41NO19 Solubility : Soluble in DMSO and DMF, Poorly soluble in MeOH and CHCl3 Insoluble in H2O, Antimicrobial activity (MIC) : Cryptococcus neoformans F-10 0.6~1.25 μg/ml, Cryptococcus laurenti 0.63 μg/ml, Rhodotorula rubra 0.63 μg/ml, Tricosporon cutaneum 1.25~5 μg/ml. Benanomicin A is isolated from Actinomadura sp. MH193-16F4. This compound exhibits excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model by intraperitoneal administration at 10mg/kg/day. In addition, this compound also has antimycotic activities via binding to mannan in the cell walls of fungi. It is recently reported that this compound has been utilized to prepare mannan cell walls by the lectin-like functionality of it.
Storage	-20°C	CAS	116249-65-1
Link	Bioactive Compounds

[Date : May 16 2025 00:07]

Benanomicin A, Antifungal via Binding to Mannan

DatasheetThis may not be the latest data sheet.

Product Code: 02966
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 827.74 Purity : > 90％ (HPLC) Molecular Formula : C39H41NO19 Solubility : Soluble in DMSO and DMF, Poorly soluble in MeOH and CHCl3 Insoluble in H2O, Antimicrobial activity (MIC) : Cryptococcus neoformans F-10 0.6~1.25 μg/ml, Cryptococcus laurenti 0.63 μg/ml, Rhodotorula rubra 0.63 μg/ml, Tricosporon cutaneum 1.25~5 μg/ml. Benanomicin A is isolated from Actinomadura sp. MH193-16F4. This compound exhibits excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model by intraperitoneal administration at 10mg/kg/day. In addition, this compound also has antimycotic activities via binding to mannan in the cell walls of fungi. It is recently reported that this compound has been utilized to prepare mannan cell walls by the lectin-like functionality of it.
Storage	-20°C	CAS	116249-65-1
Link	Bioactive Compounds

Contact

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