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Antifungal activity and significant efficacy against a Pneumocystis carinii infected mouse model Benanomicin A

Date:July 03 2020Web Page No:520046

Benanomicin A is isolated from the culture fluid of Actinomadura sp. MH193-16F4.1,2) It shows excellent activities against a wide range of fungi including Candida, Cryptococcus and Aspergillus.1,3) Also, benanomicin A demonstrated excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model.4) Moreorver, benanomicin A prevented human T-cells from HIV-1 at 30-100 µg/mL and inhibited syncytium formation by HIV-1 at 10-100 µg/mL.5)
The antifungal and anti HIV-1 activities of benanomicins and their analogues have been studied.6) Benanomicin A has antimycotic activities via binding to mannan in the cell walls of fungi.7) In recent years, the lectin-like functionality of Benanomicin A has been utilized to conduct research on preparing the mannan cell walls.8,9)

Benanomicin A

Specification

CAS#116249-65-1
Molecular FormulaC39H41NO19
Molecular Weight827.745
SourceActinomadura sp. MH193-16F4
Purity> 90% (HPLC)
SolubilitySoluble in DMSO and DMF. Poorly soluble in MeOH and CHCl3
Insoluble in H2O

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Application Note

  • Exhibited the following antimicrobial activity(MIC) 3):
    Cryptococcus neoformans 0.63-1.25 μg/ml, Cryptococcus laurenti 0.63 μg/ml, Cryptococcus terreus 0.63 μg/ml, Rhodotorula rubra 0.63 μg/ml, Trichosporon cutaneum 1.25-5.0 μg/ml
  • Benanomicin A at 12.5 mg/L (MIC) killed 99.7% of Candida albicans cells at 2 h.3)
  • 10 mg/kg/day of Benanomicin A was effective against Pneumocystis carinii pneumonia infection in the mice.4)
  • Benanomicin A was well tolerated by experimental animals; mice, rats and dogs were given intravenous doses of 600 mg/kg and rats were given 100 mg/kg per day for 28 days.3)

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Reference

  1. Takeuchi T. et al. J. Antibiot., 41(6), 807~811 (1988).
  2. Gomi S. et al. J. Antibiot., 41(8), 1019~1028 (1988).
  3. Watanabe M. et al. J. Antimicrob. Chemother., 38, 1073~1077 (1996).
  4. Yasuoka A. et al. Antimicrob. Agents Chemother., 39(3), 720~724 (1995).
  5. Hoshino H. et al. J. Antibiot., 42(2), 344~346 (1989).
  6. Kondo S. et al. J. Antibiot., 44(11), 1228~1236 (1991).
  7. Watanabe M. et al. J. Antibiot., 49(4), 366~373 (1996).
  8. Kuraoka T. et al. FEBS Open Bio, 9, 129~136 (2019).
  9. Kuraoka T. et al. Int. J. Curr. Microbiol. Appl. Sci., 8(1), 2926~2935 (2019).

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[Date : June 25 2024 00:08]

Detail Product Name Product Code Supplier Size Price
Benanomicin A,Antifungal via Binding to Mannan
DatasheetThis may not be the latest data sheet.
02966 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 116249-65-1
Link

Bioactive Compounds

[Date : June 25 2024 00:08]

Benanomicin A,Antifungal via Binding to Mannan


  • Product Code: 02966
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 116249-65-1
Link

Bioactive Compounds

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