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HOME> Products> Natural and Chemical compound> Benanomicin A

Antifungal activity and significant efficacy against a Pneumocystis carinii infected mouse model Benanomicin A

Date：July 03 2020Web Page No：520046

Benanomicin A is isolated from the culture fluid of Actinomadura sp. MH193-16F4.^1,2) It shows excellent activities against a wide range of fungi including Candida, Cryptococcus and Aspergillus.^1,3) Also, benanomicin A demonstrated excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model.⁴⁾ Moreorver, benanomicin A prevented human T-cells from HIV-1 at 30-100 µg/mL and inhibited syncytium formation by HIV-1 at 10-100 µg/mL.⁵⁾
The antifungal and anti HIV-1 activities of benanomicins and their analogues have been studied.⁶⁾ Benanomicin A has antimycotic activities via binding to mannan in the cell walls of fungi.⁷⁾ In recent years, the lectin-like functionality of Benanomicin A has been utilized to conduct research on preparing the mannan cell walls.^8,9)

Specification
Application Note
Reference

Specification

CAS#	116249-65-1
Molecular Formula	C₃₉H₄₁NO₁₉
Molecular Weight	827.745
Source	Actinomadura sp. MH193-16F4
Purity	> 90% (HPLC)
Solubility	Soluble in DMSO and DMF. Poorly soluble in MeOH and CHCl₃ Insoluble in H₂O

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Application Note

Exhibited the following antimicrobial activity(MIC) ³⁾:
Cryptococcus neoformans 0.63-1.25 μg/ml, Cryptococcus laurenti 0.63 μg/ml, Cryptococcus terreus 0.63 μg/ml, Rhodotorula rubra 0.63 μg/ml, Trichosporon cutaneum 1.25-5.0 μg/ml
Benanomicin A at 12.5 mg/L (MIC) killed 99.7% of Candida albicans cells at 2 h.³⁾
10 mg/kg/day of Benanomicin A was effective against Pneumocystis carinii pneumonia infection in the mice.⁴⁾
Benanomicin A was well tolerated by experimental animals; mice, rats and dogs were given intravenous doses of 600 mg/kg and rats were given 100 mg/kg per day for 28 days.³⁾

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Reference

Takeuchi T. et al. J. Antibiot., 41(6), 807～811 (1988).
Gomi S. et al. J. Antibiot., 41(8), 1019～1028 (1988).
Watanabe M. et al. J. Antimicrob. Chemother., 38, 1073～1077 (1996).
Yasuoka A. et al. Antimicrob. Agents Chemother., 39(3), 720～724 (1995).
Hoshino H. et al. J. Antibiot., 42(2), 344～346 (1989).
Kondo S. et al. J. Antibiot., 44(11), 1228～1236 (1991).
Watanabe M. et al. J. Antibiot., 49(4), 366～373 (1996).
Kuraoka T. et al. FEBS Open Bio, 9, 129～136 (2019).
Kuraoka T. et al. Int. J. Curr. Microbiol. Appl. Sci., 8(1), 2926～2935 (2019).

[Date : April 27 2024 00:06]

Detail Product Name Product Code Supplier Size Price

DatasheetThis may not be the latest data sheet. 02966 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS	116249-65-1
Link	Bioactive Compounds

[Date : April 27 2024 00:06]

DatasheetThis may not be the latest data sheet.

Product Code: 02966
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	116249-65-1
Link	Bioactive Compounds

Contact

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