Human Renin Quantikine^(R) ELISA Kit

R&D SystemsのHuman Reninを測定するELISAキットです。
※ 本製品は研究用です。研究用以外には使用できません。

R&D Systems offers a Human Renin Quantikine ELISA Kit (#DREN00). Renin is a secreted endopeptidase that participates in the Renin-Angiotensin System (RAS), a series of proteolytic reactions that generate Angiotensin, a peptide critical for maintaining blood pressure homeostasis, as well as fluid and salt balance. The RAS pathway begins with Renin cleavage of the precursor protein Angiotensinogen, producing the inactive peptide Angiotensin I. Angiotensin I is further cleaved generating bioactive Angiotensin. Renin is produced by juxtaglomerular cells in the kidney in response to renal sympathetic nerve activity, low sodium levels, low blood pressure, prostanoids, and a variety of hormones. It is secreted as the inactive enzyme Prorenin and becomes activated in the circulation by proteolytic removal of the propeptide. The Human Renin Quantikine ELISA Kit is designed to measure both human mature Renin and Prorenin in cell culture supernates, serum, plasma, and urine.

A cascade of proteolytic reactions in RAS results in the generation of different Angiotensin (Ang) peptides. Renin cleaves the precursor protein, Angiotensinogen, releasing the inactive peptide Angiotensin I. The carboxypeptidases ACE, ACE2, CMA1, CTSA and CPA3, the aminopeptidases APA and APN, and the endopeptidases CTSG, NEP, THOP1 and NLN participate in various pathways to generate Ang peptides with diverse functions. For example, Ang II and III act as vasoconstrictors, whereas Ang1-7 acts as a vasodilator.