文献情報 Scientific Reviews

※ 本製品は研究用です。研究用以外には使用できません。

最新の研究分野の動向とそれに関連するR&D Systems, Inc.(旧Tocris Bioscience)社製品のレビューです。

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This review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in physiological and pharmacological processes. Compounds available from Tocris are listed.

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This review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

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Two types of cannabinoid receptor have so far been identified. This review focuses particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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Revised in 2013, this review summarizes the history of the dopamine receptor subtypes and provides a guide to the ligands that act upon them. Compounds available from Tocris are listed.

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This review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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This review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer research. This review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

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Glutamate is the major excitatory amino acid transmitter in the brain. This review explains the pharmacology of mGlu receptors and the compounds acting upon them, listing those mGlu compounds available from Tocris.

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Updated in 2014, this review summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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A review of the subtypes and structures of P2 receptor families and the pharmacological probes used to study them. Compounds available from Tocris are listed.

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A synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis, outlining the putative roles of most of the known proteins and lists compounds available from Tocris.

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A summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Compounds available from Tocris are listed.

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This review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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