抗LAP/TGF-β1抗体(Anti-LAP/TGF-β1, Mouse-Mono, PE antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human LAP (TGF-beta 1) Leu30-Arg278 (Cys33Ser)Accession # P01137
Source	Monoclonal Mouse IgG1 Clone # 27232
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF‑ beta 1, rhTGF‑ beta 2, rhTGF‑ beta 1.2, rhTGF‑ beta 3, or rhTGF‑ alpha.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry. Human CD41+ platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) PE‑conjugated Monoclonal Antibody (Catalog # FAB2463P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Latency-associated Peptide
Background	LAP (TGF-beta 1)
background_content	Background: LAP (TGF-beta 1) The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.

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Citations

1. Suppressive regulatory T cells and latent transforming growth factor-?-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis
   Authors: T Hanada, S Tsuji, M Nakayama, S Wakinoue, K Kasahara, F Kimura, T Mori, K Ogasawara, T Murakami
   Reprod. Biol. Endocrinol., 2018;16(1):9.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation
   Authors: JLDS Schiavinat, R Haddad, F Saldanha-A, J Baiochi, AG Araujo, P Santos Sch, DT Covas, MA Zago, RA Panepucci
   Sci Rep, 2017;7(1):3627.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells
   Authors: M Lecendreux, G Churlaud, F Pitoiset, A Regnault, TA Tran, R Liblau, D Klatzmann, M Rosenzwajg
   PLoS ONE, 2017;12(1):e0169836.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif
   Authors: Y Zhang, W Liu, Y Chen, J Liu, K Wu, L Su, W Zhang, Y Jiang, X Zhang, Y Zhang, C Liu, L Tao, B Liu, H Zhang
   J. Immunol., 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


5. Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function
   Authors: Emily Mavin
   J. Immunol, 2016;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
   Authors: Zhu Z, Meng K, Zhong Y, Qi L, Mao X, Yu K, Zhang W, Zhu P, Ren Z, Wu B, Ji Q, Wang X, Zeng Q
   PLoS ONE, 2014;9(2):e88775.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


7. Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.
   Authors: Azukizawa H, Dohler A, Kanazawa N, Nayak A, Lipp M, Malissen B, Autenrieth I, Katayama I, Riemann M, Weih F, Berberich-Siebelt F, Lutz MB
   Eur. J. Immunol., 2011;41(5):1420-34.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


8. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
   Authors: Suzuki K, Maruya M, Kawamoto S
   Immunity, 2010;33(1):71-83.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


9. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
   Authors: Mengshol JA, Golden-Mason L, Arikawa T
   PLoS ONE, 2010;5(3):e9504.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


10. Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.
    Authors: Llopiz D, Dotor J, Casares N, Bezunartea J, Diaz-Valdes N, Ruiz M, Aranda F, Berraondo P, Prieto J, Lasarte JJ, Borras-Cuesta F, Sarobe P
    Int. J. Cancer, 2009;125(11):2614-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow

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