抗LAP抗体(Anti-LAP, TGF-β1, Human, Mouse-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human LAP (TGF-beta 1) Leu30-Arg278 (Cys33Ser)Accession # P01137
Source	Monoclonal Mouse IgG1 Clone # 27232
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF‑ beta 1, rhTGF‑ beta 2, rhTGF‑ beta 1.2, rhTGF‑ beta 3, or rhTGF‑ alpha.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	2.5 µg/106 cells	Human platelets
CyTOF-ready	Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

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Related Product & Information

Long Name	Latency-associated Peptide
Background	LAP (TGF-beta 1)
background_content	Background: LAP (TGF-beta 1) The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.

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Citations

1. Association of peripheral NK cell counts with Helios+IFNy- Tregs in patients with good long-term renal allograft function
   Authors: K Trojan, L Zhu, M Aly, R Weimer, N Bulut, C Morath, G Opelz, V Daniel
   Clin. Exp. Immunol, 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.
   Authors: Oida T, Weiner HL
   J. Immunol., 2012;185(6):3529-35.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner.
   Authors: Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S
   Immunology, 2011;133(3):278-87.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
   Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
   J. Exp. Med., 2009;206(1):169-81.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Frozen


5. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.
   Authors: Savage ND, De Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH
   J. Immunol., 2008;181(3):2220-6.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


6. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
   Authors: Kitani A, Fuss I, Pedersen A, Nawata H
   J. Immunol., 2004;172(2):834-42.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow

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