抗IL-4抗体(Anti-IL-4, Mouse, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27643
IL-4に対する抗体(Anti-IL-4, Mouse, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年07月15日 00時00分現在]
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Anti-IL-4, Mouse, Goat-Poly, Biotin |
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[在庫・価格 ：2025年07月15日 00時00分現在]
Anti-IL-4, Mouse, Goat-Poly, Biotin
文献数： 13
- 商品コード：BAF404
- メーカー：RSD
- 包装：50μg
- 価格：¥93,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse IL-4 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB404-500，スタンダードとして#404-ML-010を用いる。 別名：B cell growth factor 1 Genbank No： 3565 Protein Accession No： P07750 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Mouse | 免疫動物 | Goat |
| 交差性 | Mouse | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant mouse IL-4 (R&D Systems, Catalog # 404-ML)His23-Ser140Accession # P07750 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse IL-4 in ELISAs and Western blots. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse IL‑4 (Catalog # 404-ML) |
| Mouse IL-4 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse IL‑4 Antibody (Catalog #MAB404R ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IL‑4 Biotinylated Antibody (Catalog #BAF404 ) |
| ELISA Standard | Recombinant Mouse IL-4 Protein (Catalog #404-ML ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-4 | Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa - 18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1 - 4). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (5). Mouse IL-4 is synthesized with a 24 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (6 - 8). IL-4 exerts its effects through two receptor complexes (9, 10). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and ‑21). The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL-13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (11 - 14). IL-4 plays a dominant role in the development of allergic inflammation and asthma (13, 15). |
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References
| Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109. | |
| Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1. | |
| Lee, F. et al. (1986) Proc. Natl. Acad. Sci. 83:2061. | |
| Noma, Y. et al. (1986) Nature 319:640. | |
| Redfield, C. et al. (1991) Biochemistry 30:11029. | |
| Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141. | |
| Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451. | |
| Mosman, T.R. et al. (1987) J. Immunol. 138:1813. | |
| Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237. | |
| Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701. | |
| Paludan, S.R. (1998) Scand. J. Immunol. 48:459. | |
| Corthay, A. (2006) Scand. J. Immunol. 64:93. | |
| Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15. | |
| Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1. | |
| Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303. | |
| Long Name: | Interleukin 4 |
| Entrez Gene IDs: | 3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit) |
| Alternate Names: | B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL4; IL-4; IL-4B_cell stimulatory factor 1; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra |
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Related Research Areas
| Common gamma Chain Receptor Family | ||
| Cytokines and Receptors in Allergy and Asthma | ||
| Cytokines and Receptors in Angiogenesis | ||
| Cytokines and Receptors in Tfh Cell Differentiation and Function | ||
| Dendritic Cell Development | ||
| gamma delta T Cells | ||
| Group 2 ILCs | ||
| Inflammatory Mediators | ||
| Multiple Sclerosis and Myelin Related Molecules | ||
| Natural Killer T (NKT) Cells | ||
| Regulatory T Cells (Tregs) | ||
| T Cell Cytokine Signaling | ||
| Th2 Cells | ||
| Th9 Cells | ||
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Related Product & Information
| Background | IL-4 |
|---|---|
| background_content | Background: IL-4 Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa - 18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1 - 4). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (5). Mouse IL-4 is synthesized with a 24 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (6 - 8). IL-4 exerts its effects through two receptor complexes (9, 10). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and ‑21). The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL-13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (11 - 14). IL-4 plays a dominant role in the development of allergic inflammation and asthma (13, 15). |
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Citations
- Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells
Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
J. Allergy Clin. Immunol., 2017;139(5):1608-1620.e3.
Species: Mouse
Sample Type: Serum
Application: ELISA detection - Response patterns of cytokines/chemokines in two murine strains after irradiation.
Authors: Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
Cytokine, 2012;58(2):169-77.
Species: Mouse
Sample Type: Plasma
Application: Luminex Assay Development - CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction.
Authors: Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C
Eur. J. Immunol., 2012;42(5):1250-60.
Species: Mouse
Sample Type: Pleural Lavage Fluid
Application: ELISA Development - ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
Microbes Infect., 2009;11(4):524-30.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
Immunology, 2008;125(2):272-9.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development - Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
Am. J. Pathol., 2006;168(6):1940-50.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development - AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
Authors: Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ
Am. J. Pathol., 2002;160(4):1353-60.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development
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