抗TGF-beta 1/1.2抗体(Anti-TGF-β1, Human, Chicken-Poly antibody)
掲載日情報:2019/10/21 現在Webページ番号:26753
TGF-beta 1/1.2に対する抗体(Anti-TGF-β1, Human, Chicken-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
価格
[在庫・価格 :2025年04月26日 20時55分現在]
詳細 | 商品名 |
|
文献数 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Anti-TGF-β1, Human, Chicken-Poly |
|
8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Anti-TGF-β1, Human, Chicken-Poly |
|
8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
[在庫・価格 :2025年04月26日 20時55分現在]
Anti-TGF-β1, Human, Chicken-Poly
文献数: 8
- 商品コード:AB-101-NA
- メーカー:RSD
- 包装:1mg
- 価格:¥118,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:TGF-beta 1 Protein Accession No: P01137 |
||
---|---|---|---|
法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
抗原種 | Human | 免疫動物 | Chicken |
交差性 | Multi-species | 適用 | Western Blot |
標識 | Unlabeled | 性状 | Purified |
吸収処理 | クラス | IgY | |
クロナリティ | Polyclonal | フォーマット | |
掲載カタログ |
|
||
製品記事 | M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) Helper T Cells Marker Antibodies Myeloid-derived Suppressor Cell Marker |
||
関連記事 |
Anti-TGF-β1, Human, Chicken-Poly
文献数: 8
- 商品コード:AB-101-NA
- メーカー:RSD
- 包装:1mg
- 価格:¥118,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 別名:TGF-beta 1 Protein Accession No: P01137 |
||
---|---|---|---|
法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
抗原種 | Human | 免疫動物 | Chicken |
交差性 | Multi-species | 適用 | Western Blot |
標識 | Unlabeled | 性状 | Purified |
吸収処理 | クラス | IgY | |
クロナリティ | Polyclonal | フォーマット | |
掲載カタログ |
|
||
製品記事 | M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) Helper T Cells Marker Antibodies Myeloid-derived Suppressor Cell Marker |
||
関連記事 |
追加しました。
Product Details
Label | Unconjugated |
---|---|
Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human TGF‑ beta 1 (R&D Systems, Catalog # 240-B)Ala279-Ser390Accession # P01137 |
Source | Polyclonal Chicken IgY |
Purification | Ion exchange-purified from egg yolks |
Specificity | Detects TGF‑ beta 1/1.2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 10% cross-reactivity with recombinant amphibian TGF‑ beta 5 is observed and less than 2% cross-reactivity with recombinant human TGF‑ beta 3, recombinant chicken TGF‑ beta 3, and porcine TGF‑ beta 2 is observed. |
追加しました。
Applications and Data
Recommended Concentration | Sample | |
Western Blot | 1 µg/mL | Recombinant Human TGF-beta 1 (Catalog # 240-B) Recombinant Human TGF-beta 1.2 (Catalog # 304-B3) |
Neutralization | Measured by its ability to neutralize TGF‑ beta 1 inhibition of IL‑4-dependent proliferation in the HT‑2 mouse T cell line [Tsang, M. et al. (1995) Cytokine 7:389]. The Neutralization Dose (ND50) is typically 0.2-0.6 µg/mL in the presence of 0.25 ng/mL Recombinant Human TGF‑ beta 1 and 7.5 ng/mL Recombinant Mouse IL‑4. |
追加しました。
Related Product & Information
Long Name | Transforming Growth Factor beta 1 and 1.2 |
---|---|
Entrez Gene IDs | 7040 (Human); 21803 (Mouse); 59086 (Rat) |
Background | TGF-beta 1/1.2 |
background_content | Background: TGF-beta 1/1.2 TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-beta isoform has some non-redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation. Human TGF-beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein. A furin-like convertase processes the proprotein to generate an N-terminal 249 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF- beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain non-covalently associated after secretion, forming the small latent TGF-beta 1 complex. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins. Mature human TGF-beta 1 shares 100% aa identity with pig, dog and cow TGF-beta 1, and 99% aa identity with mouse, rat and horse TGF-beta 1. It demonstrates cross-species activity. TGF-beta 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-beta RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription. Contributions of the accessory receptors betaglycan (also known as TGF-beta RIII) and endoglin, or use of Smad-independent signaling pathways, allow for disparate actions observed in response to TGF-beta in different contexts. |
追加しました。
Citations
- Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-�-dependent pathways in genotype-specific oral cancer
Authors: S S Prime
Carcinogenesis, 2016;0(0):.
Species: Human
Sample Type: Conditioned Media
Application: Neut - Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2.
Authors: van den Berk L, Jansen B, Snowden S, Siebers-Vermeulen K, Gilissen C, Kogler G, Figdor C, Wheelock C, Torensma R
Stem Cells Dev, 2014;23(14):1582-93.
Species: Human
Sample Type: Whole Cells
Application: Neut - Isoform specificity of commercially-available anti-TGF-beta antibodies.
Authors: Mozes MM, Hodics T, Kopp JB
J. Immunol. Methods, 1999;225(1):87-93.
Species: Human
Sample Type: Recombinant Protein
Application: WB
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。