抗Guinea Pig TNF-alpha Biotinylated抗体(Anti-Guinea Pig TNF-alpha Biotinylated antibody)
掲載日情報：2021/01/28 現在Webページ番号：199432
Guinea Pig TNF-alpha Biotinylatedに対する抗体(Anti-Guinea Pig TNF-alpha Biotinylated )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
価格
[在庫・価格 ：2025年04月26日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Guinea Pig TNF-alpha Biotinylated MAb (Clone 569806) |
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[在庫・価格 ：2025年04月26日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Guinea Pig TNF-alpha Biotinylated MAb (Clone 569806)
文献数： 0
- 商品コード：BAM50351
- メーカー：RSD
- 包装：250μg
- 価格：¥118,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Guinea Pig TNF-α サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB5035，スタンダードとして#5035-TG-025を用いる。 別名：APC1 protein クローン：569806 Genbank No： 7124 Protein Accession No： P51435 |
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| 保存条件 | 法規備考 | ||
| 抗原種 | 免疫動物 | Mouse | |
| 交差性 | Guinea Pig | 適用 | ELISA |
| 標識 | Biotin | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Guinea Pig |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant guinea pig TNF-alpha Leu79-Leu234Accession # P51435 |
| Source | Monoclonal Mouse IgG1 Clone # 569806 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects recombinant guinea pig TNF-alpha in ELISAs. In sandwich immunoassays, no cross-reactivity with human, mouse, rat, porcine, canine, feline, equine, bovine, or cotton rat TNF-alpha is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Guinea Pig TNF-alpha Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Guinea Pig TNF‑ alpha Antibody (Catalog #MAB5035 ) |
| ELISA Detection (Matched Antibody Pair) | 0.5-2.0 µg/mL | Guinea Pig TNF‑ alpha Biotinylated Antibody (Catalog #BAM50351 ) |
| ELISA Standard | Recombinant Guinea Pig TNF-alpha Protein (Catalog #5035-TG ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: TNF-alpha | Tumornecrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF2, isthe prototypic ligand of the TNF superfamily. It is a pleiotropicmolecule that plays a central role in inflammation, apoptosis, andimmune system development. TNF-alpha is produced by a wide variety of immuneand epithelial cell types (1, 2). Guinea pig TNF-alpha consists of a 35amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a155 aa extracellular domain (ECD) (3). Within the ECD, guinea pig TNF-alphashares 80% - 83% aa sequence identity with human, mouse, and ratTNF-alpha. The 26 kDa type 2 transmembrane protein is assembledintracellularly to form a noncovalently linked homotrimer (4). Ligationof this complex induces reverse signaling that promotes lymphocyteco-stimulation but diminishes monocyte responsiveness (5). Cleavage ofmembrane bound TNF-alpha by TACE/ADAM17 releases a 55 kDa soluble trimericform of TNF-alpha (6, 7). TNF-alpha trimers bind the ubiquitous TNF RI and thehematopoietic cell-restricted TNF RII, both of which are also expressedas homotrimers (1, 8). TNF-alpha regulates lymphoid tissue developmentthrough control of apoptosis (2). It also promotes inflammatoryresponses by inducing the activation of vascular endothelial cells andmacrophages (2). TNF-alpha is a key cytokine in the development of severalinflammatory disorders (9). It contributes to the development of type 2diabetes through its effects on insulin resistance and fatty acidmetabolism (10, 11). | |
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References
| Idriss, H.T. and J.H. Naismith (2000) Microsc. Res. Tech. 50:184. | |
| Hehlgans, T. and K. Pfeffer (2005) Immunology 115:1. | |
| White, A.M. et al. (1997) Am. J. Physiol. 273:L524. | |
| Tang, P. et al. (1996) Biochemistry 35:8216. | |
| Eissner G. et al. (2004) Cytokine Growth Factor Rev. 15:353. | |
| Black, R.A. et al. (1997) Nature 385:729. | |
| Moss, M.L. et al. (1997) Nature 385:733. | |
| Loetscher, H. et al. (1991) J. Biol. Chem. 266:18324. | |
| Clark, I.A. (2007) Cytokine Growth Factor Rev. 18:335. | |
| Romanatto, T. et al. (2007) Peptides 28:1050. | |
| Hector, J. et al. (2007) Horm. Metab. Res. 39:250. | |
| Long Name: | Tumor Necrosis Factor alpha |
| Entrez Gene IDs: | 7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit) |
| Alternate Names: | APC1 protein; Cachectin; Cachetin; DIF; TNF; TNF, monocyte-derived; tnfa; tnf-a; TNFalpha; TNF-alpha; TNF-alphacachectin; TNFATNF, macrophage-derived; TNFSF1A; TNFSF2; TNFSF2TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; tumor necrosis factor-alpha |
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Related Research Areas
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Related Product & Information
| Background | TNF-alpha |
|---|---|
| background_content | Background: TNF-alpha Tumornecrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF2, isthe prototypic ligand of the TNF superfamily. It is a pleiotropicmolecule that plays a central role in inflammation, apoptosis, andimmune system development. TNF-alpha is produced by a wide variety of immuneand epithelial cell types (1, 2). Guinea pig TNF-alpha consists of a 35amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a155 aa extracellular domain (ECD) (3). Within the ECD, guinea pig TNF-alphashares 80% - 83% aa sequence identity with human, mouse, and ratTNF-alpha. The 26 kDa type 2 transmembrane protein is assembledintracellularly to form a noncovalently linked homotrimer (4). Ligationof this complex induces reverse signaling that promotes lymphocyteco-stimulation but diminishes monocyte responsiveness (5). Cleavage ofmembrane bound TNF-alpha by TACE/ADAM17 releases a 55 kDa soluble trimericform of TNF-alpha (6, 7). TNF-alpha trimers bind the ubiquitous TNF RI and thehematopoietic cell-restricted TNF RII, both of which are also expressedas homotrimers (1, 8). TNF-alpha regulates lymphoid tissue developmentthrough control of apoptosis (2). It also promotes inflammatoryresponses by inducing the activation of vascular endothelial cells andmacrophages (2). TNF-alpha is a key cytokine in the development of severalinflammatory disorders (9). It contributes to the development of type 2diabetes through its effects on insulin resistance and fatty acidmetabolism (10, 11). |
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