抗Mouse TGF-beta 2抗体(Anti-Mouse TGF-beta 2 antibody)
掲載日情報：2018/11/26 現在Webページ番号：196549
Mouse TGF-beta 2に対する抗体(Anti-Mouse TGF-beta 2 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2025年04月26日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Mouse TGF-beta 2 MAb (Clone 771244) |
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[在庫・価格 ：2025年04月26日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Mouse TGF-beta 2 MAb (Clone 771244)
文献数： 4
- 商品コード：MAB73461
- メーカー：RSD
- 包装：100μg
- 価格：¥94,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 別名：BSC-1 cell growth inhibitor クローン：771244 Genbank No： 7042 Protein Accession No： P27090 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
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| 製品記事 | M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies Myeloid-derived Suppressor Cell Marker |
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Anti-Mouse TGF-beta 2 MAb (Clone 771244)
文献数： 0
- 商品コード：MAB73461-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：BSC-1 cell growth inhibitor クローン：771244 Genbank No： 7042 Protein Accession No： P27090 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies 使いっきり抗体 Myeloid-derived Suppressor Cell Marker |
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant mouse TGF-beta 2Ala303-Ser414Accession # P27090 |
| Source | Monoclonal Rat IgG2B Clone # 771244 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse TGF‑ beta 2 in ELISAs and Western blots. In direct ELISAs, 100% cross‑reactivity with recombinant human (rh) TGF‑ beta 2, 25% cross‑reactivity with rhTGF‑ beta 3, and no cross‑reactivity with recombinant mouse TGF‑ beta 1 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 2 µg/mL | See below |
| Immunohistochemistry | 8-25 µg/mL | See below |
| Western Blot | |
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 | Detection of Human and Mouse TGF‑ beta 2 by Western Blot. Western blot shows lysates of Y‑79 human retinoblastoma cell line, HUVEC human umbilical vein endothelial cells, NIH‑3T3 mouse embryonic fibroblast cell line, 4T1 mouse breast cancer cell line, and NMuMG mouse mammary gland epithelial cell line. PVDF membrane was probed with 2 µg/mL of Rat Anti-Mouse TGF‑ beta 2 Monoclonal Antibody (Catalog # MAB73461) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for TGF‑ beta 2 at approximately 52 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1. |
| Immunohistochemistry | |
 | TGF‑ beta 2 in Mouse Embryo. TGF‑ beta 2 was detected in immersion fixed frozen sections of mouse embryo (15 d.p.c.) using Rat Anti-Mouse TGF‑ beta 2 Monoclonal Antibody (Catalog # MAB73461) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal processes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections. |
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Related Product & Information
| Long Name | Transforming Growth Factor beta 2 |
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| Background | TGF-beta 2 |
| background_content | Background: TGF-beta 2 TGF-beta 2 (transforming growth factor beta 2) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cysteine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-beta isoform has some non-redundant functions; for TGF-beta 2, mice with targeted deletion show defects in development of cardiac, lung, craniofacial, limb, eye, ear and urogenital systems. Mouse TGF-beta 2 cDNA encodes a 414 amino acid (aa) precursor that contains a 19 aa signal peptide and a 395 aa proprotein. A furin-like convertase processes the proprotein to generate an N-terminal 283 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF- beta 2. Disulfide-linked homodimers of LAP and TGF-beta 2 remain non-covalently associated after secretion, forming the small latent TGF-beta 2 complex. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins. Mature mouse TGF-beta 2 shares 100% aa identity with rat TGF-beta 2, and 97% aa identity with human, porcine, canine, equine and bovine TGF-beta 2. It demonstrates cross-species activity. In most cells, TGF-beta 2 signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II ser/thr kinase receptor termed TGF-beta RII, which then phosphorylates and activates another ser/thr kinase receptor, TGF-beta RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK-1. The whole complex phosphorylates and activates Smad proteins that regulate transcription. In bone -related cells, however, TGF-beta 2 also signals through TGF-beta RIIB (a splice variant of TGF-beta RII), independently of TGF-beta RIII. Use of other signaling pathways that are Smad-independent allows for disparate actions observed in response to TGF-beta in different contexts. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
- Resveratrol protects mice against SEB-induced acute lung injury and mortality by miR-193a modulation that targets TGF-? signalling
Authors: H Alghetaa, A Mohammed, M Sultan, P Busbee, A Murphy, S Chatterjee, M Nagarkatti, P Nagarkatti
J. Cell. Mol. Med., 2018;0(0):.
Species: Mouse
Sample Type: Cell Lysates
Application: WB - TGF-?1 stimulates movement of renal proximal tubular epithelial cells in a three-dimensional cell culture via an autocrine TGF-?2 production
Authors: Deyi Luo
Exp. Cell Res, 2017;350(1):132-139.
Species: Human
Sample Type: Cell Lysates
Application: WB - Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
Nat Commun, 2016;7(0):13710.
Species: Mouse
Sample Type: Tissue Homogenates
Application: WB - Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells.
Authors: Contreras-Ruiz L, Masli S
PLoS ONE, 2015;10(3):e0120284.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC OCT-embedded
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