抗ATF6, Internal抗体 | Anti-ATF6, Internal antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	FACS analysis of K562 cells using GTX81096 ATF6 antibody, Internal. Top histogram : negative controlBottom histogram : K562 cells
	WB analysis of HeLa whole cell lysate using GTX81096 ATF6 antibody, Internal. Loading : 20 μg per laneDilution : 1:16000
	IHC-P analysis of human brain tissue using GTX81096 ATF6 antibody, Internal.
	WB analysis of A2058 cell lysate (35ug/lane) using GTX81096 ATF6 antibody, Internal.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, FACS
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:1000
IHC-P	1:10-1:50
FACS	1:10-1:50

Not tested in other applications.

Calculated MW	75 kDa. ( Note )
Predict Reactivity	Mouse, Rat(>80% identity)

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.09% sodium azide.
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	KLH conjugated synthetic peptide between 350-377 amino acids of human ATF6.
Purification	Protein A purified, followed by peptide affinity purification.
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	activating transcription factor 6 , ACHM7 , ATF6A
Background	This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Database	・ Gene ID: 22926 ATF6 ・ UniProt: P18850 ATF6

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