TGF-beta 1 組換え体(リコンビナント)タンパク質 | Recombinant Human TGF-beta 1
掲載日情報：2015/01/26 現在Webページ番号：112096
R&D Systems社製の高品質なTGF-beta 1の組換え体タンパク質(Recombinant Human TGF-beta 1)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 08時35分現在]
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TGF-β1, Human, Recombinant <Transforming Growth Factor-β1> |
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TGF-β1, Human, Recombinant, Carrier-free <Transforming Growth Factor-β1> |
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[在庫・価格 ：2025年04月26日 08時35分現在]
TGF-β1, Human, Recombinant <Transforming Growth Factor-β1>
文献数： 630
- 商品コード：240-B-002
- メーカー：RSD
- 包装：2μg
- 価格：¥64,000
- 在庫：3個以上
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：CHO，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：12.8 kDa (monomer)，Genbank：7040，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：CEDLAP Genbank No： 7040 Protein Accession No： P01137 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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TGF-β1, Human, Recombinant, Carrier-free <Transforming Growth Factor-β1>
文献数： 0
- 商品コード：240-B-002/CF
- メーカー：RSD
- 包装：2μg
- 価格：¥64,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：CHO，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：12.8 kDa (monomer)，Genbank：7040，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：CEDLAP Genbank No： 7040 Protein Accession No： P01137 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Chinese Hamster Ovary cell line, CHO-derived, Ala279-Ser390
- Accession
- P01137
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE with silver staining.
- Predicted Molecular Mass
- 12.8 kDa (monomer)
- SDS-PAGE
- 12 kDa, reducing conditions24 kDa, non-reducing conditions
- Activity
- Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7
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Additional Information
- Molecule Information
- TGF-beta 1
- Aliases
- TGFB1
- Entrez Gene IDs
- 7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine)
- Background
- TGF-beta Family Ligands
- Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma.
Abushahba W, Boregowda R, Cohen-Solal K, Goydos J, Jeong B, Lasfar A, Liu F, Olabisi O, Wen Y
PLoS ONE 2102 7:e47312
Species: Human
Protein Application: Bioassay
Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.
Eur. J. Immunol. 2102 40:321-9
Transforming growth factor ??-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.
Am J Pathol 2013 182:118-31
Species: Mouse
Protein Application: Bioassay
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
Chen , Jiekai, Chen , Jing, Chen , Shen, Chen , You, Guo , Lin, Li , Dongwei, Li , Xuejia, Liang , Hanquan, Liu , He, Liu , Jing, Pei , Duanqing, Peng , Tianran, Qi , Jing, Wang , Tao, Wei , Bei, Wu , Yaran, Yang , Jiaqi, Zhang , Yixin, Zhao , Xiangjie, Zhu , Jieying
Nat Genet 2013 45:34-42
Species: Mouse
Protein Application: Bioassay
MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
Abou-Kheir W, Casey O, Fang L, Hynes P, Kelly K, Liu Y, Martin P, Seng V, Sheppard-Tillman H, Stephens R, Yi M, Yin J
Oncogene 2013 32:296-306
Species: Mouse
Protein Application: Cell Culture Substrate
MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
Badal , Shawn S, Chang , Benny H , Danesh , Farhad R, Long , Jianyin, Rodriguez , Antony, Wang , Yin
J Biol Chem 2013 288:36202-14
Species: Mouse
Protein Application: cell culture
Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
Fujimoto M, Hamaguchi Y, Hasegawa M, Huu DL, Matsushita T, Nakasone Y, Sato S, Takehara K, Yanaba M
Am. J. Pathol. 2012 180:365-74
Species: Mouse
Protein Application: In Vivo
Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Caillat-Zucman S, Choukem SP, Dupuy S, Lambert M, Lebbe C, Pages C, Tognarelli S, Zucman D
PLoS Pathog. 2012 8:e1002486
Species: Human
Protein Application: Bioassay
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Holzmann K, Kestler HA, Manta C, Nakayama T, Niess JH, Radulovic K, Rossini V, Wegenka UM
J. Immunol. 2012 188:2001-13
Species: Mouse
Protein Application: Bioassay
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Abt MC, Artis D, Beura LK, Casey KA, Fraser KA, Hogquist K, Lucas PJ, Masopust D, Moran A, Schenkel JM, Vezys V, Wherry EJ
J. Immunol. 2012 188:4866-75
Species: Mouse
Protein Application: Bioassay
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