IL-23 組換え体(リコンビナント)タンパク質 | Recombinant Mouse IL-23
掲載日情報：2015/01/26 現在Webページ番号：111850
R&D Systems社製の高品質なIL-23の組換え体タンパク質(Recombinant Mouse IL-23)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2026年04月20日 00時00分現在]
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IL-23, Mouse, Recombinant, Carrier-free |
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[在庫・価格 ：2026年04月20日 00時00分現在]
IL-23, Mouse, Recombinant
文献数： 108
- 商品コード：1887-ML-010
- メーカー：RSD
- 包装：10μg
- 本製品は取扱中止になりました
| 説明文 | Genbank No：
51561
Protein Accession No： P43432(p40)&Q9EQ14(p19) |
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| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies SEC-MALS分析済みの組換えタンパク質（R&D Systems） |
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| 関連記事 | |||
IL-23, Mouse, Recombinant, Carrier-free
文献数： 0
- 商品コード：1887-ML-010/CF
- メーカー：RSD
- 包装：10μg
- 本製品は取扱中止になりました
| 説明文 | Genbank No：
51561
Protein Accession No： P43432(p40)&Q9EQ14(p19) |
||
|---|---|---|---|
| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 掲載カタログ |
|
||
| 製品記事 | Helper T Cells Marker Antibodies SEC-MALS分析済みの組換えタンパク質（R&D Systems） |
||
| 関連記事 | |||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (stably transfected)-derived
- Accession
- P43432 (p40) & Q9EQ14 (p19)
- Purity
- >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 57 kDa
- SDS-PAGE
- 66 kDa, reducing conditions
- Activity
- Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al. (2003) J. Biol. Chem. 278
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Additional Information
- Molecule Information
- IL-23
- Aliases
- IL23A; SGRF
- Entrez Gene IDs
- 51561 (Human); 83430 (Mouse)
- Background
- IL-23
- Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8- and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Ben-Hamo , Rotem, Burns , Evan J, Efroni , Sol, Kuchroo , Vijay K, Mascanfroni , Ivan D, Mayo , Lior, Patel , Bonny, Quintana , Francisc, Robson , Simon C, Sloma , Ido, Vieira , Silvio M, Wu , Yan, Yeste , Ada
Nat Immunol 2013 14:1054-63
Species: Mouse
Protein Application: Bioassay
Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
Brown GD, Chan YR, Dunaway CW, Gessner MA, Lilly LM, Metz AE, Nelson MP, Ouyang W, Steele C, Weaver CT, Werner JL
Infect. Immun. 2012 80:410-7
Species: Mouse
Protein Application: Bioassay
Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.
Dubin PJ, Eisenstatt JR, Fox MD, Kolls JK, Logar A, Martz A
Infect. Immun. 2012 80:398-409
Species: Mouse
Protein Application: In Vivo
Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
Alcaide P, Bu DX, Croce KJ, Lichtman AH, Luscinskas FW, Maganto-Garcia E, Newton G, Travers R
J. Immunol. 2012 188:1421-30
Species: Mouse
Protein Application: Bioassay
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Abt MC, Artis D, Beura LK, Casey KA, Fraser KA, Hogquist K, Lucas PJ, Masopust D, Moran A, Schenkel JM, Vezys V, Wherry EJ
J. Immunol. 2012 188:4866-75
Species: Mouse
Protein Application: Bioassay
Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
Baker J, Fitzgerald K, Flanagan K
PLoS ONE 2012 7:e40443
Species: Mouse
Protein Application: Bioassay
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A 2012 109:9971-6
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Apetoh L, Aymeric L, Benlagha K, Boucontet L, Casares N, Chaput N, Dechanet-Merville J, Delahaye NF, Ghiringhelli F, Ibrahim N, Ikuta K, Kroemer G, Lasarte JJ, Locher C, Ma Y, Matsuzaki G, Mattarollo SR, Pereira P, Ryffel B, Smyth MJ, Tesniere A, Zitvogel L
J. Exp. Med. 2011 208:491-503
Species: Mouse
Protein Application: Bioassay
Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model.
Benson JM, DiGiovanni J, Elloso MM, Gutshall LL, Iwakura Y, Kamijima R, Kanda T, Miyoshi K, Nakajima H, Nakajima K, Naso MF, Sano S, Shiga T, Takaishi M, Tarutani M
J. Immunol. 2011 186:4481-9
Species: Mouse
Protein Application: In Vivo
RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.
Berard M, Cua D, Di Santo JP, Dulauroy S, Eberl G, Kleinschek M, Lochner M, Satoh-Takayama N, Sawa S
Nat. Immunol. 2011 12:320-6
Species: Mouse
Protein Application: Bioassay
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