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Glyoxylase-I inhibitor COTC

Date:July 07 2021Web Page No:95016

COTC (Glyoxalase-I Inhibitor)

COTC

[Date : September 18 2021 00:30]

Detail Product Name Product Code Supplier Size Price
COTC <Glyoxalase-I Inhibitor>
DatasheetThis may not be the latest data sheet.
14675 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 57449-30-6
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[Date : September 18 2021 00:30]

COTC <Glyoxalase-I Inhibitor>


  • Product Code: 14675
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 57449-30-6
Link


Specification

Code No.14675
CAS#57449-30-6
Molecular FormulaC11H14O6
Molecular Weight242.227
SourceStreptomyces griseosporeus. , MD287-CF3
Appearancewhite powder
Purity>90% (HPLC)
Long Term Storageat - 20 °C
SolubilitySoluble in MeOH, DMSO and H2O
Insoluble in n-Hexane


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Application Note

2-Crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) is an inhibitor of glyoxylase I isolated from the culture filtrate of Streptomyces griseosporeus MD287-CF3.1,2) It shows IC50 values against rat liver crude glyoxalase and yeast glyoxalase I at 1.8 mM and 1.4 mM, respectively, in a reaction mixture containing 1.59 mM of reduced glutathione and preincubated for 3 minutes before enzyme addition.1,3) COTC shows a strong growth inhibition of HeLa cells and Ehrlich ascites carcinoma with low toxicity. (LD50 mice: 90 mg/kg i.v.)1) COTC reacts with glutathione and other SH-compound to form corresponding thioethers.2,4) COTC blocks enzymatic activity of alkaline phosphodiesterase derived from murine lymphoblastoma L5178Y cells (IC50: 60 μg/ml).5) COTC and aclarubicin exhibits synergistic activity on aclarubicin-resistant cells, but not on the parental cells.5)

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Reference


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