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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Minosaminomycin

Aminoglycoside antibiotic that inhibits bacterial protein synthesis Minosaminomycin

Date：February 25 2021Web Page No：95012

Minosaminomycin is an aminoglycoside antibiotic structurally related to kasugamycin which obtained from the culture fluid of Streptomyces sp. MA514-A1.^{1, 2)}
Minosaminomycin exhibits growth inhibitory activity against mycobacteria including Mycobacterium tuberculosis, and inhibits protein synthesis in Escherichia coli cell-free system stronger than kasugamycin.^{1, 3)}

Specification
Application Note
Reference

Specification

CAS#	51746-09-9
Molecular Formula	C₂₅H₄₆N₈O₁₀
Molecular Weight	618.689
Source	Streptomyces sp. MA514-A1
Purity	> 98% (HPLC)
Solubility	Soluble in MeOH, DMSO, H₂O. Insoluble in Hexane

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Application Note

Inhibits phage f2 RNA-directed protein synthesis in a cell-free system of E. coli by 50% at 0.2 µM. It is 100-times more potent than kasugamycin in this system.³⁾
Shows minimum inhibitory concentration of 1.56 µg/ml and 6.25 µg/ml against Mycobacterium smegmatis ATCC 607 and Mycobacterium phlei respectively.¹⁾

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Reference

Hamada M., et al., J. Antibiot., 27 (1), 81～83 (1974). [PMID:4843050]
Iinuma K., et al., J. Antibiot., 28 (8), 613～615 (1975). [PMID:1158785]
Suzukake K., et al., J. Antibiot., 30 (2), 132～140 (1977). [PMID:321408]

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Minosaminomicin,Bacterial Protein Synthesis Inhibitor
DatasheetThis may not be the latest data sheet. 02872 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	4°C	CAS	51746-09-9
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Minosaminomicin,Bacterial Protein Synthesis Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 02872
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	4°C	CAS	51746-09-9
Link	Bioactive Compounds

Contact

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