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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Minosaminomycin

Aminoglycoside antibiotic that inhibits bacterial protein synthesis Minosaminomycin

Date：February 25 2021Web Page No：95012

Minosaminomycin is an aminoglycoside antibiotic structurally related to kasugamycin which obtained from the culture fluid of Streptomyces sp. MA514-A1.^{1, 2)}
Minosaminomycin exhibits growth inhibitory activity against mycobacteria including Mycobacterium tuberculosis, and inhibits protein synthesis in Escherichia coli cell-free system stronger than kasugamycin.^{1, 3)}

Specification
Application Note
Reference

Specification

CAS#	51746-09-9
Molecular Formula	C₂₅H₄₆N₈O₁₀
Molecular Weight	618.689
Source	Streptomyces sp. MA514-A1
Purity	> 98% (HPLC)
Solubility	Soluble in MeOH, DMSO, H₂O. Insoluble in Hexane

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Application Note

Inhibits phage f2 RNA-directed protein synthesis in a cell-free system of E. coli by 50% at 0.2 µM. It is 100-times more potent than kasugamycin in this system.³⁾
Shows minimum inhibitory concentration of 1.56 µg/ml and 6.25 µg/ml against Mycobacterium smegmatis ATCC 607 and Mycobacterium phlei respectively.¹⁾

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Reference

Hamada M., et al., J. Antibiot., 27 (1), 81～83 (1974). [PMID:4843050]
Iinuma K., et al., J. Antibiot., 28 (8), 613～615 (1975). [PMID:1158785]
Suzukake K., et al., J. Antibiot., 30 (2), 132～140 (1977). [PMID:321408]

[Date : May 16 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Minosaminomicin, Bacterial Protein Synthesis Inhibitor
DatasheetThis may not be the latest data sheet. 02872 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 618.689 Purity : >98％ (HPLC) Molecular Formula : C25H46N8O10 Solubility : Soluble in MeOH, DMSO, and H2O, Insoluble in Hexane. Minosaminomycin inhibits phage f2 RNA-directed protein synthesis in a cell-free system of Escherichia coli by 50% at 0.2 µM. It was also reported that minimum inhibitory concentrations of the bioactive compound were determined as 1.56 µg/ml for Mycobacterium smegmatis ATCC 607 and 6.25 µg/ml for Mycobacterium phlei, respectively.
Storage	-20°C	CAS	51746-09-9
Link	Bioactive Compounds

[Date : May 16 2025 00:07]

Minosaminomicin, Bacterial Protein Synthesis Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 02872
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 618.689 Purity : >98％ (HPLC) Molecular Formula : C25H46N8O10 Solubility : Soluble in MeOH, DMSO, and H2O, Insoluble in Hexane. Minosaminomycin inhibits phage f2 RNA-directed protein synthesis in a cell-free system of Escherichia coli by 50% at 0.2 µM. It was also reported that minimum inhibitory concentrations of the bioactive compound were determined as 1.56 µg/ml for Mycobacterium smegmatis ATCC 607 and 6.25 µg/ml for Mycobacterium phlei, respectively.
Storage	-20°C	CAS	51746-09-9
Link	Bioactive Compounds

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