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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Cyclamidomycin

Nucleoside Diphosphate Kinase (NDPK) Inhibitor, Desdanine Cyclamidomycin

Date：February 25 2021Web Page No：95011

Cyclamidomycin (synonyms: Desdanine) is obtained from the cultures of Streptomyces sp.MA130-A1¹⁾. While small molecule (less than M.W.140), it inhibits nucleoside diphosphate kinase of Escherichia coli²⁾ and the growth of gram-positive and gram-negative bacteria^{2, 3)}.
Also, cyclamidomycin inhibits plaque formation of male-specific coliphages and suppress the multiplication of both RNA phage Qβ and filamentous DNA phage f1 ⁴⁾.

Specification
Application Note
Reference

Specification

CAS#	35663-85-5
Molecular Formula	C₇H₁₀N₂O
Molecular Weight	138.170
Source	Streptomyce sp. MA130-A1
Purity	> 98% (HPLC)
Solubility	Soluble in H₂O. Insoluble in MeOH and Hexane

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Application Note

Cyclamidomycin inhibits 63％ of 20μg/ml nucleoside diphosphokinase²⁾.
Cyclamidomycin suppress the multiplication of RNA phage Qβ and filamentous DNA phage f1 at 3.13-6.26 μg/ml³⁾.

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Reference

Takahashi S., et al., J. Antibiot., 24 (12), 902～903 (1971). [PMID:5140536]
Saeki T., et al., J. Antibiot., 25 (6), 343～349 (1972). [PMID:4568012]
Argoudelis, A. D., et al., J. Antibiot., 25 (7), 432～433 (1972). [PMID:4661099]
Tanida S., et al., J. Antibiot., 29 (7), 754～758 (1976). [PMID:783105]

[Date : April 27 2024 00:06]

Detail Product Name Product Code Supplier Size Price

DatasheetThis may not be the latest data sheet. 01541 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	4°C	CAS	35663-85-5
Link	Bioactive Compounds

[Date : April 27 2024 00:06]

DatasheetThis may not be the latest data sheet.

Product Code: 01541
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	4°C	CAS	35663-85-5
Link	Bioactive Compounds

Contact

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