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Nucleoside Diphosphate Kinase (NDPK) Inhibitor, Desdanine Cyclamidomycin

Date:February 25 2021Web Page No:95011

Cyclamidomycin (synonyms: Desdanine) is obtained from the cultures of Streptomyces sp.MA130-A1 1). While small molecule (less than M.W.140), it inhibits nucleoside diphosphate kinase of Escherichia coli 2) and the growth of gram-positive and gram-negative bacteria 2, 3).
Also, cyclamidomycin inhibits plaque formation of male-specific coliphages and suppress the multiplication of both RNA phage Qβ and filamentous DNA phage f1 4).

Cyclamidomycin-Structure

Specification

CAS#35663-85-5
Molecular FormulaC7H10N2O
Molecular Weight138.170
SourceStreptomyce sp. MA130-A1
Purity> 98% (HPLC)
SolubilitySoluble in H2O. Insoluble in MeOH and Hexane

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Application Note

  • Cyclamidomycin inhibits 63% of 20μg/ml nucleoside diphosphokinase 2).
  • Cyclamidomycin suppress the multiplication of RNA phage Qβ and filamentous DNA phage f1 at 3.13-6.26 μg/ml 3).

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Reference

  1. Takahashi S., et al., J. Antibiot., 24 (12), 902~903 (1971). [PMID:5140536]
  2. Saeki T., et al., J. Antibiot., 25 (6), 343~349 (1972). [PMID:4568012]
  3. Argoudelis, A. D., et al., J. Antibiot., 25 (7), 432~433 (1972). [PMID:4661099]
  4. Tanida S., et al., J. Antibiot., 29 (7), 754~758 (1976). [PMID:783105]

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[Date : July 23 2024 00:06]

Detail Product Name Product Code Supplier Size Price
Cyclamidomycin,Nucleoside Diphosphate Kinase (NDPK) Inhibitor,Antibacterial (Gram-Positive & Negative)
DatasheetThis may not be the latest data sheet.
01541 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage 4°C CAS 35663-85-5
Link

Bioactive Compounds

[Date : July 23 2024 00:06]

Cyclamidomycin,Nucleoside Diphosphate Kinase (NDPK) Inhibitor,Antibacterial (Gram-Positive & Negative)


  • Product Code: 01541
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage 4°C CAS 35663-85-5
Link

Bioactive Compounds

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