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Nano-type Chondroitin
Chondroitin Sulfate Oligosaccharide Readily Soluble in Water Nano-type Chondroitin
Date:December 15 2020Web Page No:95009
Chondroitin sulfate oligosaccharide is a low-molecular-weight, non-enzymatic product of natural high molecular weight chondroitin sulfate extracted and purified from the cartilage of stingrays caught in Hokkaido.
Products containing high amounts of chondroitin sulfate A (CS-A rich)*1, non-sulfated chondroitin oligosaccharides, and high molecular weight chondroitin sulfate are also available.
*1 CS-A rich series is derived from pig cartilage.
* The products are for research use only. Not for therapeutic or diagnostic use.
Background
Chondroitin sulfate is a high-molecular substance with a molecular weight in the hundreds of thousands, consisting of multiple disaccharide bonds of glucuronic acid (GlcA) and sulfated N-acetylgalactosamine (GalNAc). "Nano-type Chondroitin" is a low-molecular-weight oligosaccharide of chondroitin sulfate produced by a non-enzymatic microchemical process.

Lineup
| Type | Degree of polymerization | CS-A rich*2 | Sulfation | Average M.W. |
Content (wt%) |
Appearance | Main structure | Code |
|---|---|---|---|---|---|---|---|---|
| Mixed | Oligosaccharide mix | ― | ✓ | 2,000 or less |
90 | White powder | [GlcAβ1-3GalNAc(4S/6S)]n | MBF834001 |
| Oligosaccharide mix | ✓ | ✓ | 2,000 or less |
90 | [GlcAβ1-3GalNAc(4S/6S)]n | MBF834018 | ||
| Odd-numbered oligosaccharides (GG) mix | ― | Non-sulfated | 2,000 or less |
95 | GalNAcβ1-4[GlcAβ1-3GalNAc]2-6 | MBF834926 | ||
| Polymer | Polymer | ― | ✓ | 70,000 or less |
90 | [GlcAβ1-3GalNAc(4S/6S)]n | MBF833905 |
*2 CS-A rich series is derived from pig cartilage.
* GG: N-acetyl-D-galactosamine at both ends.
* The molecular weight of chondroitin sulfate oligosaccharides is based on the assumption that Na is added to all sulfate groups and glucuronic acid is in the proton form.
* Even-numbered oligosaccharides have the [GlcA-GalNAc (6S)] structure but contain 20-30% of the [GalNAc (6S)-GlcA] structure.
Information for #MBF834001
Features
- The main sugar composition is 2 to 12 sugars.
- It dissolves easily in water (Water-soluble test).
- It is made from 100% natural ingredients grown in Hokkaido, so there is no traceability problem.
- In an absorption test using reversed intestinal absorption, it was confirmed that the absorption was at least 40 times greater than that of high molecular weight chondroitin (Absorption test).
- It was confirmed that the interaction with various cytokines was maintained and that the bioactivity was equivalent to that of high molecular weight chondroitin sulfate.
- It has been confirmed that it inhibits lipid droplet accumulation in adipocytes.
- It has been confirmed that it suppresses obesity in mice fed a high-fat diet.
- It has been confirmed that it suppresses arthritis caused by autoimmune diseases more effectively than high molecular weight chondroitin sulfate (Anti-inflammatory test).
- It has been confirmed in human intervention studies that it is safe and effective in improving locomotive syndrome (Figure 5).
Specification
| Item | Standard |
|---|---|
| Appearance | White powder |
| Chondroitin sulfate amount | ≧90% |
| Average M.W. | 2 kDa |
| Moisture | ≦10% |
| pH (1% solution) | 3.5-5.5 |
| Heavy metal (as Pb) | ≦10 ppm |
| Total number of bacteria | ≦3,000 cfu/g |
| Coliform bacteria | Negative |
| Granularity | 30 mesh pass |
Example of Use
Water-soluble test
Each samples were added in water and the dissolve time was measured.
Absorption test using everted sac method (Rat)
Chondroitin sulfate oligosaccarides(#MBF834001) show excellent water absorbency compared to macromolecule conventional chondroitin sulfate.
Anti-inflammatory test using arthritis model mouse
Chondroitin sulfate oligosaccarides(#MBF834001) show excellent recovery from arthritis compared to conventional chondroitin sulfate.
Chondroitin sulfate oligosaccarides(#MBF834001) show excellent water absorbency compared to macromolecule conventional chondroitin sulfate.
Chondroitin sulfate oligosaccarides(#MBF834001) show excellent recovery from arthritis compared to conventional chondroitin sulfate.
Reference
- Daily Oral Chondroitin Sulfate Oligosaccharides for Knee Joint Pain in Healthy Subjects: A Randomized, Blinded, Placebo-Controlled Study
Nishimura, M., et al., The Open Nutrition Journal., 12:10 (2018). [DOI:10.2174/1874288201812010010] - Structural modulation of gut microbiota by chondroitin sulfate and its oligosaccharide
Shanga, Q., et al., Int. J. of Biological Macromolecules., 89:489 (2016). [PMID:27164502] - Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice
Sakai, S., et al., J. Biol. Chem., 281 (29):19872 (2006). [PMID:16624819] - Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice
Cho, S.Y., et al., Biol. Pharm. Bull., 27 (1):47 (2004). [PMID:14709897] - Effect of Molecular Sizes of Chondroitin Sulfate on Interaction with L-Selectin
Igarashi, N., et al., Int. J. of Carbohydrate Chem., 856142:(2013). [DOI:10.1155/2013/856142]
Product Information
Mixed type
[Date : November 18 2025 00:13]
| Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Chondroitin sulfate oligosaccharides |
MBF834001 | MBF | 10 g | $83 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharides (CS-A rich) |
MBF834018 | MBF | 5 g | $97 | |||||||||||||||||||||||||||||||
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Chondroitin non Sulfated odd-numbered oligosaccharides GG form |
MBF834926 | MBF | 100 mg | $1,795 | |||||||||||||||||||||||||||||||
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[Date : November 18 2025 00:13]
Chondroitin sulfate oligosaccharides
- Product Code: MBF834001
- Supplier: MBF
- Size: 10g
- Price: $83
| Description |
Chondroitin sulfate oligosaccharide is a non-enzymatically low molecular weight product of natural high molecular weight chondroitin sulfate extracted and purified from the cartilage of skates. Degree of polymerization: Oligosaccharide mix, M.W.: 2,000 or less, Content: 90 wt%, Main structure: [GlcAβ1-3GalNAc(4S/6S)]n, From: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin sulfate oligosaccharides (CS-A rich)
- Product Code: MBF834018
- Supplier: MBF
- Size: 5g
- Price: $97
| Description |
Chondroitin sulfate oligosaccharide obtained by non-enzymatically reducing the molecular weight of natural high molecular weight chondroitin sulfate extracted and purified from pig cartilage by a unique microchemical process. It contains high content of chondroitin sulfate A (CS-A). Degree of polymerization: Oligosaccharide Mix, M.W.: 2,000 or less, Content: 90 wt%, Main structure: [GlcAβ1-3GalNAc (4 S/6S)]n, Form: White powder, Origin: Pig cartilage |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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Chondroitin non Sulfated odd-numbered oligosaccharides GG form
- Product Code: MBF834926
- Supplier: MBF
- Size: 100mg
- Price: $1,795
| Description |
Degree of polymerization: Oligosaccharide (GG) Mix, M.W.: 2,000 or less, Content: 95 wt%, Main structure: GalNAcβ1-4 [GlcAβ1-3GalNAc]2-6, Shape: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Polymer type
[Date : November 18 2025 00:13]
| Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Chondroitin sulfate (Skate cartilage) |
MBF833905 | MBF | 10 g | $69 | |||||||||||||||||||||||||||||||
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[Date : November 18 2025 00:13]
Chondroitin sulfate (Skate cartilage)
- Product Code: MBF833905
- Supplier: MBF
- Size: 10g
- Price: $69
| Description |
Natural high molecular weight chondroitin sulfate extracted and purified from the cartilage of skunk cabbage. M.W.: More than 70,000, Content: 90 wt%, Main structure: [GlcAβ1-3GalNAc (4 S/6S)]n, Form: White powder. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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Related Products
Uniform types (n-mer) are also available!
[Date : November 18 2025 00:13]
| Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Chondroitin sulfate oligosaccharide, 2mer |
MBF834100 | MBF | 50 mg | $690 | |||||||||||||||||||||||||||||||
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Chondroitin Sulfate Oligosaccharides Sodium salt, 3mer-GG |
MBF834308 | MBF | 50 mg | $690 | |||||||||||||||||||||||||||||||
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Chondroitin Sulfate Oligosaccharides Sodium salt, 3mer-UU |
MBF834209 | MBF | 50 mg | $690 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 4mer |
MBF834407 | MBF | 50 mg | $690 | |||||||||||||||||||||||||||||||
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Chondroitin non Sulfated oligosaccharide, 5mer-GG |
MBF834568 | MBF | 50 mg | $2,485 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 5mer-GG |
MBF834551 | MBF | 50 mg | $897 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 5mer-UU |
MBF834506 | MBF | 50 mg | $897 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 6mer |
MBF834605 | MBF | 50 mg | $897 | |||||||||||||||||||||||||||||||
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Chondroitin non Sulfated oligosaccharide, 7mer-GG |
MBF834667 | MBF | 50 mg | $2,485 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 7mer-GG (CS-A rich) |
MBF834674 | MBF | 50 mg | $994 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 8mer |
MBF834704 | MBF | 50 mg | $1,105 | |||||||||||||||||||||||||||||||
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Chondroitin non Sulfated oligosaccharide, 9mer-GG |
MBF834766 | MBF | 50 mg | $2,485 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 10mer |
MBF834803 | MBF | 50 mg | $1,105 | |||||||||||||||||||||||||||||||
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Chondroitin non Sulfated oligosaccharide, 11mer-GG |
MBF834865 | MBF | 50 mg | $2,485 | |||||||||||||||||||||||||||||||
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Chondroitin sulfate oligosaccharide, 12mer |
MBF834902 | MBF | 50 mg | $1,105 | |||||||||||||||||||||||||||||||
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[Date : November 18 2025 00:13]
Chondroitin sulfate oligosaccharide, 2mer
- Product Code: MBF834100
- Supplier: MBF
- Size: 50mg
- Price: $690
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 2mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 2mer, M.W.: 499, Content: 98 wt%, Main structure: GlcAβ1-3GalNAc(6S), Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin Sulfate Oligosaccharides Sodium salt, 3mer-GG
- Product Code: MBF834308
- Supplier: MBF
- Size: 50mg
- Price: $690
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 3mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 3mer-GG, M.W.: 804, Content: 98 wt%, Main structure: GalNAc(6S)β1-4GlcAβ1-3GalNAc(6S), Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin Sulfate Oligosaccharides Sodium salt, 3mer-UU
- Product Code: MBF834209
- Supplier: MBF
- Size: 50mg
- Price: $690
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 3mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 3mer-UU, M.W.: 675, Content: 98 wt%, Main structure: GlcAβ1-3GalNAc(6S)β1-4GlcA, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
|
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Chondroitin sulfate oligosaccharide, 4mer
- Product Code: MBF834407
- Supplier: MBF
- Size: 50mg
- Price: $690
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 4mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 4mer, M.W.: 980, Content: 98 wt%, Main structure: [GlcAβ1-3GalNAc (6S)]2, Form: White powder. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin non Sulfated oligosaccharide, 5mer-GG
- Product Code: MBF834568
- Supplier: MBF
- Size: 50mg
- Price: $2,485
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 5mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 5mer(0S)-GG, M.W.: 1,023, Content: Single peak in HPLC, Main structure: GalNAcβ1-4[GlcAβ1-3GalNAc]2, Form: White powder. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
|
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Chondroitin sulfate oligosaccharide, 5mer-GG
- Product Code: MBF834551
- Supplier: MBF
- Size: 50mg
- Price: $897
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 5mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 5mer-GG, M.W.: 1,285, Content: 98 wt%, Main structure: GalNAc(6S)β1-4[GlcAβ1-3GalNAc(6S)]2, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin sulfate oligosaccharide, 5mer-UU
- Product Code: MBF834506
- Supplier: MBF
- Size: 50mg
- Price: $897
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 5mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 5mer-UU, M.W.: 1,156, Content: 98 wt%, Main structure: [GlcAβ1-3GalNAc(6S)]2β1-4GlcA, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin sulfate oligosaccharide, 6mer
- Product Code: MBF834605
- Supplier: MBF
- Size: 50mg
- Price: $897
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧98%) with a sugar polymerization degree of 6mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 6mer, M.W.: 1,461, Content: 98 wt%, Main structure: [GlcAβ1-3GalNAc(6S)]3, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
|
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Chondroitin non Sulfated oligosaccharide, 7mer-GG
- Product Code: MBF834667
- Supplier: MBF
- Size: 50mg
- Price: $2,485
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 7mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 7mer-GG, M.W.: 1,425, Content: Single peak in HPLC, Main structure: GalNAcβ1-4[GlcAβ1-3GalNAc]3, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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Chondroitin sulfate oligosaccharide, 7mer-GG (CS-A rich)
- Product Code: MBF834674
- Supplier: MBF
- Size: 50mg
- Price: $994
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (≧95%) with a sugar polymerization degree of 7mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 7mer-GG, M.W.: 1,767, Content: 95 wt%, Main structure: GalNAc(4S)β1-4[GlcAβ1-3GalNAc(4S)]3, Form: White powder, Origin: Porcine cartilage |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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Chondroitin sulfate oligosaccharide, 8mer
- Product Code: MBF834704
- Supplier: MBF
- Size: 50mg
- Price: $1,105
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 8mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 8mer, M.W.: 1,942, Content: Single peak in HPLC, Main structure: [GlcAβ1-3GalNAc(6S)]4, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin non Sulfated oligosaccharide, 9mer-GG
- Product Code: MBF834766
- Supplier: MBF
- Size: 50mg
- Price: $2,485
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 9mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 9mer(0S)-GG, M.W.: 1,826, Content: Single peak in HPLC, Main structure: GalNAcβ1-4[GlcAβ1-3GalNAc]4, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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Chondroitin sulfate oligosaccharide, 10mer
- Product Code: MBF834803
- Supplier: MBF
- Size: 50mg
- Price: $1,105
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 10mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 10mer, M.W.: 2,423, Content: Single peak in HPLC, Main structure: [GlcAβ1-3GalNAc(6S)]5, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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Chondroitin non Sulfated oligosaccharide, 11mer-GG
- Product Code: MBF834865
- Supplier: MBF
- Size: 50mg
- Price: $2,485
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 11mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 11mer(0S)-GG, M.W.: 2,228, Content: Single peak in HPLC, Main structure: GalNAcβ1-4[GlcAβ1-3GalNAc]5, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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Chondroitin sulfate oligosaccharide, 12mer
- Product Code: MBF834902
- Supplier: MBF
- Size: 50mg
- Price: $1,105
| Description |
Chondroitin sulfate oligosaccharide separated and purified to high purity (Single peak in HPLC) with a sugar polymerization degree of 12mer. It is ideal for various biochemical tests, cell tests, and administration tests to small animals. Degree of polymerization: 12mer, M.W.: 2,904, Content: Single peak in HPLC, Main structure: [GlcAβ1-3GalNAc(6S)]6, Form: White powder |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Dry | CAS | |
| Link |
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