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Bacterial Protein Synthesis Inhibitor, Antibacterial (Gram-Positive & Negative) Althiomycin

Date:November 09 2020Web Page No:90004

Althiomycin is a sulfur-containing peptide antibiotic isolated from Streptomyces althioticus No.245-Z2. 1-3)
Althiomycin

Specification

CAS#12656-40-5
Molecular FormulaC16H17N5O6S2
Molecular Weight439.461
SourceStreptomyces althioticus No. 245-Z2
Purity> 98% (HPLC)
SolubilitySoluble in ethyl cellosolve, pyridine, DMSO.
Poorly soluble in MeOH, EtOAc and acetone. Insoluble in H2O.

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Application Note

  • Althiomycin is active against both gram-positive and gram-negative bacteria such as Streptococcus pneumoniae, Bacillus anthracis, Escherichia coli and Salmonella Typhi has relatively low toxicity. 1)
  • Althiomycin inhibits protein synthesis in both intact cells and cell-free system of E.coli. 4)
  • Althiomycin inhibits the puromycin reaction without showing any inhibition against aminoacyl-tRNA synthesis and binding of aminoacyl-tRNA to ribosomes. 4)
  • Total synthesis of althiomycin and activity of its derivatives have been studied. 5-6)

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Reference

  1. Yamaguchi, H., et al., J. Antibiot., 10 (5), 195~200 (1957). [PMID:13513511]
  2. Sakakibara, H., et al., J. Antibiot., 27 (11), 897~899 (1974). [PMID:4452663]
  3. Kirst, H.A., et al., J. Antibiot., 28 (4), 286~291 (1975). [PMID:1150528]
  4. Fujimoto, H., et al., J. Antibiot., 23 (6), 271~275 (1970). [PMID:4917791]
  5. Zarantonello, P., et al., Bioorg. Med. Chem Lett., 12 (4), 561~565 (2002). [PMID:11844672]
  6. Inami, K. & Shiba, T., Bull. Chem. Soc. Jpn., 58 (1), 352~360 (1985). [doi.org/10.1246/bcsj.58.352]

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[Date : July 15 2024 00:05]

Detail Product Name Product Code Supplier Size Price
Althiomycin,Bacterial Protein Synthesis Inhibitor,Antibacterial (Gram-Positive & Negative)
DatasheetThis may not be the latest data sheet.
14660 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 12656-40-5
Link

Bioactive Compounds

[Date : July 15 2024 00:05]

Althiomycin,Bacterial Protein Synthesis Inhibitor,Antibacterial (Gram-Positive & Negative)


  • Product Code: 14660
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 12656-40-5
Link

Bioactive Compounds

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