Forphenicine : Inhibitor for alkaline phosphatase

Date:November 09 2020Web Page No:90003

Forphenicine

[Date : January 26 2021 23:29]

Detail Product Name Product Code Supplier Size Price
Forphenicine
DatasheetThis may not be the latest data sheet.
09636 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS
Link

Bioactive Compounds

[Date : January 26 2021 23:29]

Forphenicine


  • Product Code: 09636
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS
Link

Bioactive Compounds

Specification

Code No.09636
CAS#57784-96-0
Molecular FormulaC6H9NO4
Molecular Weight195.174
SourceStreptomyces fulvoviridis var. acarbodicus MC974-A5
AppearancePale yellow crystals
Purity> 90% (HPLC)
Long Term Storageat - 20 °C
SolubilitySoluble in diluted acetic acid and H2O and diluted aqueous HCl
Insoluble in MeOH, Benzene, Pyridine and DMSO.

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Application Notes

Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5.1,2) Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC50 value is 0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli. The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate and its Ki value is 1.64×10-7M.1) Forphenicine enhances delayed-type hypersensitivity(DTH) and increase the number of antibody-forming in mice. Forphenicinol, orally administrable forphenicine derivative, has been studied.3,4)

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References

1) Forphenicine, an inhibitor of alkaline phosphatase produced by actinomycetes. Aoyagi T, al. J Antibiot. 1978 31(3) 244-246.
2) The structure of forphenicine. Yamamoto T, et al. J Antibiot.. 1978 31(5) 483-484.
3) Synthesis of forphenicinol and forphenicine. Morishima H, et al. J Antibiot.. 1982 35(11) 1500-1506.
4) Studies on effects of forphenicinol on immune responses. Ishizuka M, et al.. J Antibiot. 1982 35(8) 1042-1048.

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CONTACT

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