Inhibitor for alkaline phosphatase Forphenicine

Date:November 09 2020Web Page No:90003

Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5 1, 2). In mice, Forphenicine enhances delayed-hypersensitivity to sheep red blood cells(SRBCs) and antibody production capacity 3).
As part of drug discovery research, Forphenicinol (#09637), orally administrable forphenicine derivative, has been synthesized 4).
Forphenicine

Specification

CAS#57784-96-0
Molecular FormulaC6H9NO4
Molecular Weight195.174
SourceStreptomyces fulvoviridis var. acarbodicus MC974-A5
Purity> 90% (HPLC)
SolubilitySoluble in diluted acetic acid, H2O and diluted aqueous HCl
Insoluble in MeOH, Benzene, Pyridine and DMSO.

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Application Note

  • Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC50:0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli 1).
  • The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate (Ki:1.64×10-7M) 1).
  • Forphenicine enhances delayed-type hypersensitivity(DTH) and increase the number of antibody-forming in mice 4)

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Reference

  1. Aoyagi T., et al., J. Antibiot., 31 (3), 244~246 (1978). [PMID:348665]
  2. Yamamoto T., et al., J. Antibiot., 31 (5), 483~484 (1978). [PMID:670089]
  3. Ishizuka M., et al., J. Antibiot., 35 (8), 1042~1048 (1982). [PMID:7142005]
  4. Morishima H., et al., J. Antibiot., 35 (11), 1500~1506 (1982). [PMID:7161189]

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[Date : June 25 2024 00:08]

Detail Product Name Product Code Supplier Size Price
Forphenicine,Alkaline Phosphatase Inhibitor
DatasheetThis may not be the latest data sheet.
09636 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 57784-96-0
Link

Bioactive Compounds

[Date : June 25 2024 00:08]

Forphenicine,Alkaline Phosphatase Inhibitor


  • Product Code: 09636
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 57784-96-0
Link

Bioactive Compounds


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