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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Forphenicine

Inhibitor for alkaline phosphatase Forphenicine

Date：November 09 2020Web Page No：90003

Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5 ^{1, 2)}. In mice, Forphenicine enhances delayed-hypersensitivity to sheep red blood cells(SRBCs) and antibody production capacity ³⁾.
As part of drug discovery research, Forphenicinol (#09637), orally administrable forphenicine derivative, has been synthesized ⁴⁾.

Specification
Application Note
Reference

Specification

CAS#	57784-96-0
Molecular Formula	C₆H₉NO₄
Molecular Weight	195.174
Source	Streptomyces fulvoviridis var. acarbodicus MC974-A5
Purity	> 90% (HPLC)
Solubility	Soluble in diluted acetic acid, H₂O and diluted aqueous HCl Insoluble in MeOH, Benzene, Pyridine and DMSO.

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Application Note

Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC₅₀:0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli ¹⁾.
The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate (Ki:1.64×10^-7M) ¹⁾.
Forphenicine enhances delayed-type hypersensitivity(DTH) and increase the number of antibody-forming in mice ⁴⁾

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Reference

Aoyagi T., et al., J. Antibiot., 31 (3), 244～246 (1978). [PMID:348665]
Yamamoto T., et al., J. Antibiot., 31 (5), 483～484 (1978). [PMID:670089]
Ishizuka M., et al., J. Antibiot., 35 (8), 1042～1048 (1982). [PMID:7142005]
Morishima H., et al., J. Antibiot., 35 (11), 1500～1506 (1982). [PMID:7161189]

[Date : May 16 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Forphenicine, Alkaline Phosphatase Inhibitor
DatasheetThis may not be the latest data sheet. 09636 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 195.174 Purity : > 90％ (HPLC) Molecular Formula : C9H9NO4 Solubility : Soluble in dilute acetic acid, dilute aqueous HCl, and H2O Insoluble in MeOH, Benzene, Pyridine and DMSO, Forphenicine is an inhibitor of alkaline phosphatase which was isolated from bacterial culture of Streptomyces fulvoviridis var. acarbodicus MC974-A5. It was reported that this compound enhances delayed-type hypersensitivity to sheep red blood cells (SRBCs) and antibody production in mice.
Storage	-20°C	CAS	57784-96-0
Link	Bioactive Compounds

[Date : May 16 2025 00:07]

Forphenicine, Alkaline Phosphatase Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 09636
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 195.174 Purity : > 90％ (HPLC) Molecular Formula : C9H9NO4 Solubility : Soluble in dilute acetic acid, dilute aqueous HCl, and H2O Insoluble in MeOH, Benzene, Pyridine and DMSO, Forphenicine is an inhibitor of alkaline phosphatase which was isolated from bacterial culture of Streptomyces fulvoviridis var. acarbodicus MC974-A5. It was reported that this compound enhances delayed-type hypersensitivity to sheep red blood cells (SRBCs) and antibody production in mice.
Storage	-20°C	CAS	57784-96-0
Link	Bioactive Compounds

Contact

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