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Inhibitor for alkaline phosphatase Forphenicine

Date：November 09 2020Web Page No：90003

Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5 ^{1, 2)}. In mice, Forphenicine enhances delayed-hypersensitivity to sheep red blood cells(SRBCs) and antibody production capacity ³⁾.
As part of drug discovery research, Forphenicinol (#09637), orally administrable forphenicine derivative, has been synthesized ⁴⁾.

Specification
Application Note
Reference

Specification

CAS#	57784-96-0
Molecular Formula	C₆H₉NO₄
Molecular Weight	195.174
Source	Streptomyces fulvoviridis var. acarbodicus MC974-A5
Purity	> 90% (HPLC)
Solubility	Soluble in diluted acetic acid, H₂O and diluted aqueous HCl Insoluble in MeOH, Benzene, Pyridine and DMSO.

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Application Note

Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC₅₀:0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli ¹⁾.
The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate (Ki:1.64×10^-7M) ¹⁾.
Forphenicine enhances delayed-type hypersensitivity(DTH) and increase the number of antibody-forming in mice ⁴⁾

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Reference

Aoyagi T., et al., J. Antibiot., 31 (3), 244～246 (1978). [PMID:348665]
Yamamoto T., et al., J. Antibiot., 31 (5), 483～484 (1978). [PMID:670089]
Ishizuka M., et al., J. Antibiot., 35 (8), 1042～1048 (1982). [PMID:7142005]
Morishima H., et al., J. Antibiot., 35 (11), 1500～1506 (1982). [PMID:7161189]

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Forphenicine,Alkaline Phosphatase Inhibitor
DatasheetThis may not be the latest data sheet. 09636 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS	57784-96-0
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Forphenicine,Alkaline Phosphatase Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 09636
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	57784-96-0
Link	Bioactive Compounds

Contact

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