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Forphenicine : Inhibitor for alkaline phosphatase

Date：November 09 2020Web Page No：90003

[Date : January 26 2021 23:29]

Detail Product Name Product Code Supplier Size Price

Forphenicine
DatasheetThis may not be the latest data sheet. 09636 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS
Link	Bioactive Compounds

[Date : January 26 2021 23:29]

Forphenicine

DatasheetThis may not be the latest data sheet.

Product Code: 09636
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS
Link	Bioactive Compounds

Contact

Specification
Application Notes
References

Specification

Code No.	09636
CAS#	57784-96-0
Molecular Formula	C₆H₉NO₄
Molecular Weight	195.174
Source	Streptomyces fulvoviridis var. acarbodicus MC974-A5
Appearance	Pale yellow crystals
Purity	> 90% (HPLC)
Long Term Storage	at - 20 °C
Solubility	Soluble in diluted acetic acid and H₂O and diluted aqueous HCl Insoluble in MeOH, Benzene, Pyridine and DMSO.

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Application Notes

Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5.1,2) Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC50 value is 0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli. The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate and its Ki value is 1.64×10-7M.1) Forphenicine enhances delayed-type hypersensitivity(DTH) and increase the number of antibody-forming in mice. Forphenicinol, orally administrable forphenicine derivative, has been studied.3,4)

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References

1) Forphenicine, an inhibitor of alkaline phosphatase produced by actinomycetes. Aoyagi T, al. J Antibiot. 1978 31(3) 244-246.
2) The structure of forphenicine. Yamamoto T, et al. J Antibiot.. 1978 31(5) 483-484.
3) Synthesis of forphenicinol and forphenicine. Morishima H, et al. J Antibiot.. 1982 35(11) 1500-1506.
4) Studies on effects of forphenicinol on immune responses. Ishizuka M, et al.. J Antibiot. 1982 35(8) 1042-1048.

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CONTACT

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