Forphenicine : Inhibitor for alkaline phosphatase
Date:November 09 2020Web Page No:90003

[Date : January 26 2021 23:29]
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Forphenicine DatasheetThis may not be the latest data sheet. |
09636 | IMCInstitute of Microbial Chemistry | 1 mg | $500 | |||||||||||||||||||||||||||||||
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[Date : January 26 2021 23:29]
Forphenicine
DatasheetThis may not be the latest data sheet.
- Product Code: 09636
- Supplier: IMC
- Size: 1mg
- Price: $500
Description | |||
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Storage | -20°C | CAS | |
Link |
Specification
Code No. | 09636 |
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CAS# | 57784-96-0 |
Molecular Formula | C6H9NO4 |
Molecular Weight | 195.174 |
Source | Streptomyces fulvoviridis var. acarbodicus MC974-A5 |
Appearance | Pale yellow crystals |
Purity | > 90% (HPLC) |
Long Term Storage | at - 20 °C |
Solubility | Soluble in diluted acetic acid and H2O and diluted aqueous HCl Insoluble in MeOH, Benzene, Pyridine and DMSO. |
Application Notes
Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5.1,2) Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC50 value is 0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli. The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate and its Ki value is 1.64×10-7M.1) Forphenicine enhances delayed-type hypersensitivity(DTH) and increase the number of antibody-forming in mice. Forphenicinol, orally administrable forphenicine derivative, has been studied.3,4)
References
1) Forphenicine, an inhibitor of alkaline phosphatase produced by actinomycetes. Aoyagi T, al. J
Antibiot. 1978 31(3) 244-246.
2) The structure of forphenicine. Yamamoto T, et al. J Antibiot.. 1978 31(5) 483-484.
3) Synthesis of forphenicinol and forphenicine. Morishima H, et al. J Antibiot.. 1982 35(11) 1500-1506.
4) Studies on effects of forphenicinol on immune responses. Ishizuka M, et al.. J Antibiot. 1982 35(8)
1042-1048.
CONTACT
export@funakoshi.co.jp
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