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HOME> Products> Natural and Chemical compound> PQA-18 | Funakoshi
HOME> Products> Natural and Chemical compound> Enzyme inhibitor> PQA-18 | Funakoshi

Newly developed immunosuppressor PQA-18 | Funakoshi

Date：December 22 2017Web Page No：80681

Funakoshi Co.,Ltd.

PQA-18 is a newly developed immunosuppressor. PQA-18 strongly inhibits p21-activated kinase 2 (PAK2), which is related to IL-2, IL-4, IL-6 and TNF-alpha production.

PQA-18 is the abbreviation of "Prenylated Quinolinecarboxylic Acid compound 18", and following effects are reported.

PAK2 activity is reduced in a dose-dependent manner, when PQA-18 is added to Jurkat cells.
IL-2, IL-4, IL-6 and TNF-alpha production are reduced, when PQA-18 is added to human peripheral lymphocytes stimulated for 24 hours by ConA (10 ug/ml).
Antigen specific immune reactions is inhibited when PQA-18 is intraperitoneally administered to mouse.
Nc/Nga mouse (13 weeks old), applied petrolatum ointment (100 mg) containing PQA-18 shows less skin irritation and blood IgE amount is reduced.

Features
Example Data
Reference
Price

Features

Higher stability in blood compared to FK-506.
Compatible with in vivo and in vitro application.
CAS number : 1604678-82-1
Molecular Formula : C₂₅H₃₁NO₄
Molecular Weight (Average) : 409.52
Purity : >98%
Solubility : DMSO *

* If you see insoluble, try vortex or heat at 37C. Recommended stock solution concentration is 10 - 20 mM.

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Example Data

PQA-18 is added to Jurkat cells. IL-2 production is reduced in a dose-dependent manner.

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Reference

Ogura M, et al, Biochem Pharmacol, 105:55-65 (2016).

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Price

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

PQA-18, Immunosuppressor
DatasheetThis may not be the latest data sheet. FDV-0009 FNAFunakoshi Co.,Ltd. 5 mg $300

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Description	PQA-18 is a newly developed immunosuppressor. PQA-18 strongly inhibits p21-activated kinase 2 (PAK2), which is related to IL-2, IL-4, IL-6 and TNF-alpha production.
Storage	-20°C	CAS	1604678-82-1
Link

[Date : February 15 2024 12:37]

PQA-18, Immunosuppressor

DatasheetThis may not be the latest data sheet.

Product Code: FDV-0009
Supplier: FNA
Size: 5mg
Price: $300

Description	PQA-18 is a newly developed immunosuppressor. PQA-18 strongly inhibits p21-activated kinase 2 (PAK2), which is related to IL-2, IL-4, IL-6 and TNF-alpha production.
Storage	-20°C	CAS	1604678-82-1
Link

Contact

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CONTACT

export@funakoshi.co.jp

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