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PQA-18 | Funakoshi
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PQA-18 | Funakoshi
Newly developed immunosuppressor PQA-18 | Funakoshi
Date:December 22 2017Web Page No:80681
Funakoshi Co.,Ltd.

PQA-18 is a newly developed immunosuppressor. PQA-18 strongly inhibits p21-activated kinase 2 (PAK2), which is related to IL-2, IL-4, IL-6 and TNF-alpha production.
PQA-18 is the abbreviation of "Prenylated Quinolinecarboxylic Acid compound 18", and following effects are reported.
- PAK2 activity is reduced in a dose-dependent manner, when PQA-18 is added to Jurkat cells.
- IL-2, IL-4, IL-6 and TNF-alpha production are reduced, when PQA-18 is added to human peripheral lymphocytes stimulated for 24 hours by ConA (10 ug/ml).
- Antigen specific immune reactions is inhibited when PQA-18 is intraperitoneally administered to mouse.
- Nc/Nga mouse (13 weeks old), applied petrolatum ointment (100 mg) containing PQA-18 shows less skin irritation and blood IgE amount is reduced.
Features
- Higher stability in blood compared to FK-506.
- Compatible with in vivo and in vitro application.
- CAS number : 1604678-82-1
- Molecular Formula : C25H31NO4
- Molecular Weight (Average) : 409.52
- Purity : >98%
- Solubility : DMSO *
- Product Code: FDV-0009
- Supplier: FNA
- Size: 5mg
- Price: $300
* If you see insoluble, try vortex or heat at 37C. Recommended stock solution concentration is 10 - 20 mM.
Example Data

PQA-18 is added to Jurkat cells. IL-2 production is reduced in a dose-dependent manner.
Reference
Ogura M, et al, Biochem Pharmacol, 105:55-65 (2016).
Price
[Date : February 09 2025 00:06]
Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
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PQA-18, Immunosuppressor DatasheetThis may not be the latest data sheet. |
FDV-0009 | FNAFunakoshi Co.,Ltd. | 5 mg | $300 | |||||||||||||||||||||||||||||||
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[Date : February 09 2025 00:06]
PQA-18, Immunosuppressor
DatasheetThis may not be the latest data sheet.
Description |
PQA-18 is a newly developed immunosuppressor. PQA-18 strongly inhibits p21-activated kinase 2 (PAK2), which is related to IL-2, IL-4, IL-6 and TNF-alpha production. |
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Storage | -20°C | CAS | 1604678-82-1 |
Link |
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CONTACT
export@funakoshi.co.jp
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