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Inhibitor for Protein Phosphatase 2A (PP2A) Cytostatin (sodium salt)

Date:February 24 2016Web Page No:80633

Cytostatin is a natural product derived from actinomycetes that inhibits protein phosphatase 2A (PP2A) non-competitively.


Cytostatin

Specification

CAS#457070-06-3 (sodium salt)
Molecular FormulaC21H32O7P Na
Molecular Weight450.444
SourceStreptomyces sp. MA514-A1
Purity> 75% (HPLC)
SolubilitySoluble in MeOH, DMSO, H2O. Insoluble in n-Hexane

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Application Note

  • Cytostatin inhibits the adhesion of B16 melanoma cells to laminin (IC50=1.3 μg/ml) and collagen type IV (IC50=1.4 μg/ml), but not inhibits the adhesionto fibronectin.
  • Cytostatin inhibits protein phosphatase 2A in a non competitive manner (IC50=0.09 µg/ml).

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Reference

  1. Amemiya, M., et al., J. Antibiotics, 47 (5), 536~540 (1994). [PMID:8040050]
  2. Masuda, T., et al., J. Antibiotics, 48 (6), 528~529 (1995). [PMID:7622443]
  3. Kawada, M., et al., Biochim. Biophys. Acta., 1452 (2), 209~217 (1999). [PMID:10559474]
  4. Kawada, M., et al., Int. Immunopharmacol., 3 (2), 179~188 (2003). [PMID:12586599]

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[Date : June 25 2024 00:08]

Detail Product Name Product Code Supplier Size Price
Cytostatin (Sodium Salt),Protein Phosphatase 2A (PP2A) Inhibitor
DatasheetThis may not be the latest data sheet.
10664 IMCInstitute of Microbial Chemistry 1 mg $500

Description Inhibitor for Protein Phosphatase 2A
Storage -20°C CAS 457070-06-3 (sodium salt), 156856-30-3 (salt free form)
Link

Natural compound Product List
Bioactive Compounds

[Date : June 25 2024 00:08]

Cytostatin (Sodium Salt),Protein Phosphatase 2A (PP2A) Inhibitor


  • Product Code: 10664
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description Inhibitor for Protein Phosphatase 2A
Storage -20°C CAS 457070-06-3 (sodium salt), 156856-30-3 (salt free form)
Link

Natural compound Product List
Bioactive Compounds

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