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Optically Active Fmoc-Protected β-Hydroxy-α-amino Acid (Serine) Derivatives Chiral Building Blocks for Peptide Synthesis and Drug Discovery Research

Date：June 30 2026Web Page No：718195

Institute of Microbial Chemistry

Optically active Fmoc-protected β-hydroxy-α-amino acid derivatives are highly valuable chiral building blocks for peptide and medium-sized molecule drug discovery. β-Hydroxy-α-amino acid residues are key structural motifs found in numerous peptide natural products and peptide-based therapeutics, including vancomycin.
Leveraging proprietary technology developed by the Institute of Microbial Chemistry (BIKAKEN), we have successfully commercialized a unique series of non-natural serine derivatives possessing two contiguous stereogenic centers—compounds that have previously been difficult to obtain.

* Please do not hesitate to contact Funakoshi if you need a Structure Data Format (SDF) file and/or bulk purchase (large quantity) of the compounds.
* This product is for research use only.


Chemical structure of optically active Fmoc-protected β-hydroxy-α-amino acid (serine)

The chiral building blocks are developed and supplied by proprietary technologies
from Institute of Microbial Chemistry (Bikaken).


Key Features

  • Ready for Direct Use in Solid-Phase Peptide Synthesis (SPPS):
    These N-Fmoc-protected amino acid derivatives, the most widely used protecting group strategy for SPPS, are supplied with the side-chain hydroxyl group also protected, enabling their direct use in peptide synthesis and in the preparation of amino acid analogues and derivatives.

  • High-Quality Chiral Reagents:
    All products meet stringent quality standards with chemical purity >95% and optical purity >95% ee, making them reliable chiral building blocks for synthetic applications.

  • A Unique Product Line Enabled by Proprietary Catalytic Technology:
    Utilizing the highly stereoselective direct catalytic asymmetric aldol reaction1 developed by the Institute of Microbial Chemistry (BIKAKEN), we have established a stable supply of diverse non-natural amino acid derivatives with a wide variety of side-chain structures. These products are ideal for expanding peptide drug discovery libraries and for the exploration of novel amino acid derivatives.


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Product table

All the compounds below are, Purity: >95% (HPLC), Optical Purity: >95% ee.
Click the compound name to view detailed information, click the product code to view the price list,
and click the chemical structure to enlarge the image.

Product Name Structure Size Molecular Formula Molecular Weight CAS No. Product code
(2R,3S)-Fmoc-3-cyclobutyl-Ser(TBS)-OH (2R,3S)-Fmoc-3-cyclobutyl-Ser(TBS)-OHの構造式 200 mg C28H37NO5Si 495.69 ー CBB012
(2S,3R)-Fmoc-3-cyclobutyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-cyclobutyl-Ser(TBS)-OHの構造式 200 mg C28H37NO5Si 495.69 ー CBB011
(2R,3S)-Fmoc-3-cyclohexyl-Ser(TBS)-OH (2R,3S)-Fmoc-3-cyclohexyl-Ser(TBS)-OHの構造式 200 mg C30H41NO5Si 523.75 ー CBB006
(2S,3R)-Fmoc-3-cyclohexyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-cyclohexyl-Ser(TBS)-OHの構造式 200 mg C30H41NO5Si 523.75 ー CBB005
(2R,3S)-Fmoc-3-cyclopentyl-Ser(TBS)-OH (2R,3S)-Fmoc-3-cyclopentyl-Ser(TBS)-OHの構造式 200 mg C29H39NO5Si 509.72 ー CBB010
(2S,3R)-Fmoc-3-cyclopentyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-cyclopentyl-Ser(TBS)-OHの構造式 200 mg C29H39NO5Si 509.72 ー CBB009
(2R,3S)-Fmoc-3-cyclopropyl-Ser(TBS)-OH (2R,3S)-Fmoc-3-cyclopropyl-Ser(TBS)-OHの構造式 200 mg C27H35NO5Si 481.66 ー CBB004
(2S,3R)-Fmoc-3-cyclopropyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-cyclopropyl-Ser(TBS)-OHの構造式 200 mg C27H35NO5Si 481.66 ー CBB003
(2R,3S)-Fmoc-3-ethyl-Ser(TBS)-OH (2R,3S)-Fmoc-3-ethyl-Ser(TBS)-OHの構造式 200 mg C26H35NO5Si 469.65 ー CBB016
(2S,3R)-Fmoc-3-ethyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-ethyl-Ser(TBS)-OHの構造式 200 mg C26H35NO5Si 469.65 2382557-25-5 CBB015
(2R,3S)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH (2R,3S)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OHの構造式 200 mg C29H41NO5Si 511.73 ー CBB002
(2S,3R)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH (2S,3R)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OHの構造式 200 mg C29H41NO5Si 511.73 ー CBB001
(2R,3S)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH (2R,3S)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OHの構造式 200 mg C27H37NO5Si 483.68 1447759-04-7 CBB008
(2S,3R)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH (2S,3R)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OHの構造式 200 mg C27H37NO5Si 483.68 1379595-58-0 CBB007
(2R,3S)-Fmoc-3-pentyl-Ser(TBS)-OH (2R,3S)-Fmoc-3-pentyl-Ser(TBS)-OHの構造式 200 mg C29H41NO5Si 511.73 ー CBB020
(2S,3R)-Fmoc-3-pentyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-pentyl-Ser(TBS)-OHの構造式 200 mg C29H41NO5Si 511.73 ー CBB019
(2S,3R)-Fmoc-3-propyl-Ser(TBS)-OH (2S,3R)-Fmoc-3-propyl-Ser(TBS)-OHの構造式 200 mg C27H37NO5Si 483.68 ー CBB017
(2R,3S)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH (2R,3S)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OHの構造式 200 mg C29H39NO6Si 525.72 ー CBB014
(2S,3R)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH (2S,3R)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OHの構造式 200 mg C29H39NO6Si 525.72 ー CBB013

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Reference

  1. Takeuchi, T. and Shibasaki, M., Org. Lett., 26(37), 7981(2024). [PMID:39255778]


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Product Information

[Date : July 08 2026 00:08]

Detail Product Name Product Code Supplier Size Price
(2R,3S)-Fmoc-3-cyclobutyl-Ser(TBS)-OH
 CBB012 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C28H37NO5Si, M.W.：495.69, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclobutyl-Ser(TBS)-OH
 CBB011 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C28H37NO5Si, M.W.：495.69, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-cyclohexyl-Ser(TBS)-OH
 CBB006 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C30H41NO5Si, M.W.：523.75, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclohexyl-Ser(TBS)-OH
 CBB005 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C30H41NO5Si, M.W.：523.75, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-cyclopentyl-Ser(TBS)-OH
 CBB010 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H39NO5Si, M.W.：509.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclopentyl-Ser(TBS)-OH
 CBB009 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H39NO5Si, M.W.：509.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-cyclopropyl-Ser(TBS)-OH
 CBB004 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C27H35NO5Si, M.W.：481.66, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclopropyl-Ser(TBS)-OH
 CBB003 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C27H35NO5Si, M.W.：481.66, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-ethyl-Ser(TBS)-OH
 CBB016 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C26H35NO5Si, M.W.：469.65, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH
 CBB002 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH
 CBB001 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH
 CBB008 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C27H37NO5Si, M.W.：483.68, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS 1447759-04-7
Link

(2S,3R)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH
 CBB007 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C27H37NO5Si, M.W.：483.68, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS 1379595-58-0
Link

(2R,3S)-Fmoc-3-pentyl-Ser(TBS)-OH
 CBB020 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-pentyl-Ser(TBS)-OH
 CBB019 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-propyl-Ser(TBS)-OH
 CBB017 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C27H37NO5Si, M.W.：483.68, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH
 CBB014 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H39NO6Si, M.W.：525.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH
 CBB013 IMCInstitute of Microbial Chemistry 200 mg $500

Description Molecular Formula : C29H39NO6Si, M.W.：525.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

[Date : July 08 2026 00:08]

(2R,3S)-Fmoc-3-cyclobutyl-Ser(TBS)-OH


  • Product Code: CBB012
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C28H37NO5Si, M.W.：495.69, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclobutyl-Ser(TBS)-OH


  • Product Code: CBB011
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C28H37NO5Si, M.W.：495.69, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-cyclohexyl-Ser(TBS)-OH


  • Product Code: CBB006
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C30H41NO5Si, M.W.：523.75, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclohexyl-Ser(TBS)-OH


  • Product Code: CBB005
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C30H41NO5Si, M.W.：523.75, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-cyclopentyl-Ser(TBS)-OH


  • Product Code: CBB010
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H39NO5Si, M.W.：509.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclopentyl-Ser(TBS)-OH


  • Product Code: CBB009
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H39NO5Si, M.W.：509.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-cyclopropyl-Ser(TBS)-OH


  • Product Code: CBB004
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C27H35NO5Si, M.W.：481.66, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-cyclopropyl-Ser(TBS)-OH


  • Product Code: CBB003
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C27H35NO5Si, M.W.：481.66, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-ethyl-Ser(TBS)-OH


  • Product Code: CBB016
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C26H35NO5Si, M.W.：469.65, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH


  • Product Code: CBB002
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-(1-ethylpropyl)-Ser(TBS)-OH


  • Product Code: CBB001
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH


  • Product Code: CBB008
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C27H37NO5Si, M.W.：483.68, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS 1447759-04-7
Link

(2S,3R)-Fmoc-3-(1-methylethyl)-Ser(TBS)-OH


  • Product Code: CBB007
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C27H37NO5Si, M.W.：483.68, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS 1379595-58-0
Link

(2R,3S)-Fmoc-3-pentyl-Ser(TBS)-OH


  • Product Code: CBB020
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-pentyl-Ser(TBS)-OH


  • Product Code: CBB019
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H41NO5Si, M.W.：511.73, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-propyl-Ser(TBS)-OH


  • Product Code: CBB017
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C27H37NO5Si, M.W.：483.68, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2R,3S)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH


  • Product Code: CBB014
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H39NO6Si, M.W.：525.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link

(2S,3R)-Fmoc-3-(tetrahydropyran-4-yl)-Ser(TBS)-OH


  • Product Code: CBB013
  • Supplier: IMC
  • Size: 200mg
  • Price: $500

Description Molecular Formula : C29H39NO6Si, M.W.：525.72, Purity : >95% (HPLC), Optical purity : >95% ee, Optical activity Fmoc-β-hydroxy-α-amino acid (Serine) derivative.
Storage -20°C,Dark Storage,Dry CAS
Link


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