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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Ceramidastin

Inhibitor of seramidase isolated from Penicillium sp. Ceramidastin

Date：February 17 2026Web Page No：520113

Ceramidastin is a natural bioactive compound which was extracted from a kind of fungi ,Penicillium sp, and inhibits ceramidase in Peudomonas aeruginosa¹⁾. It was reported that the ceramidase from ceramidase-producing bacteria causes aggravation of atopic dermatitis. Therefore, it is expected that ceramidastin is useful for various researches such as maintenance of skin barrier function, inflammation control, and lipid metabolism etc., by the inhibition of ceramide degradation^1,2).

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Structure of Ceramidastin (#19378)

Influence of bacterial infection between ceramidase activity and regulation of lipid homeostasis
Difference between Ceramidastin and Rubratoxin A
Specification
Application Note
Reference
Product Information

Influence of bacterial infection between ceramidase activity and regulation of lipid homeostasis

Ceramidase is an important enzyme to degrade ceramide to sphingosine and free fatty acids. Five ceramidases in human are known that acidic ceramidase, neutral ceramidase, alkaline ceramidases 1, 2, and 3. These ceramidases are classified by differentiation of cellular localization and optimum pH.³⁾
Pseudomonas aeruginosa utilizes skin lipids in human and animal, especially ceramide, during the infection stage. The bacteria induce their ceramidases strongly during biofilm formation. Then, sphingosine and sphingosine-1-phosphate which are metabolites by the enzymes directly involve in additional induction of Pseudomonas aeruginosa ceramidases and inhibition of PPARδ which is a nuclear receptor in skin cells in host animals.⁴⁾
In addition, the biofilm formed by Pseudomonas aeruginosa inhibits expression of PPARδ via induction of miR-106b. It has been reported that this low expression level of PPARδ suppresses expression of ABCA12 as lipid-transporter gene, causing imbalance of skin lipid homeostasis and deficiency of skin barrier function.⁴⁾

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Difference between Ceramidastin and Rubratoxin A

Rubratoxin A harboring a similar structure of ceramidstin is known as a natural bioactive compound extracted from fungus. Both compounds have different functional activities and are noticed that their relationship between their structural difference and activities.

Ceramidastin inhibits ceramidase in Pseudomonas aeruginosa but not PP2A in human.⁴⁾
Rubratoxin A inhibits PP2A in human but not ceramidase in Pseudomonas aeruginosa.¹⁾

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Specification

CAS#	1155308-84-1 (for an anhydride form, as a reference)
Molecular Formula	C₂₆H₃₄O₁₁･Na₂O (as a disodium salt hydrate)
Molecular Weight	584.526 (as a disodium salt hydrate)
Purity	>90% (HPLC)
Solubility	Soluble in H₂O.

* This product is supplied as a disodium salt hydrate form.

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Application Note

Ceramidastin inhibited Pseudomonas aeruginosa ceramidase (IC₅₀: 6.25 μg/ml) but not ceramidase in human at 200 μg/ml.¹⁾
Mouse model of atopic dermatitis showed the increase of mast cells in the dermis by Pseudomonas aeruginosa ceramidase application. Ceramidastin significantly inhibited the increase of mast cells.¹⁾.
When ceramidastin was administered to mice intravenously, no fatality was observed up to 6.25 mg/kg.¹⁾
Ceramidastin did not inhibit human ceramidase at 200 μg/ml.⁴⁾

*Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Inoue, H., et al., J. Antibiotics, 62 (2), 63～67 (2009). [PMID:19132056]
Sinha, M., et al., Ann. Surg., 277 (3), e634～e647 (2023). [PMID:35129518]
Parveen, F., et al., Cells, 8 (12), 1573 (2019). [PMID:31817238]
Wada, S., et al., Cancer Sci., 101 (3), 743～750 (2010). [PMID:20028386]

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Product Information

[Date : March 02 2026 00:07]

Detail Product Name Product Code Supplier Size Price

Ceramidastin, Bacterial ceramidase inhibitor
DatasheetThis may not be the latest data sheet. 19378 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 584.526 (as a disodium salt hydrate) Purity : >90% (HPLC) Molecular Formula : C26H34O11・Na2O (as a disodium salt hydrate) Solubility : Soluble in H2O Ceramidastin inhibits Pseudomonas aeruginosa ceramidase (IC50: 6.25 μg/ml) but not human ceramidase.
Storage	-20°C	CAS	1155308-84-1 (anhydride)
Link

[Date : March 02 2026 00:07]

Ceramidastin, Bacterial ceramidase inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 19378
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 584.526 (as a disodium salt hydrate) Purity : >90% (HPLC) Molecular Formula : C26H34O11・Na2O (as a disodium salt hydrate) Solubility : Soluble in H2O Ceramidastin inhibits Pseudomonas aeruginosa ceramidase (IC50: 6.25 μg/ml) but not human ceramidase.
Storage	-20°C	CAS	1155308-84-1 (anhydride)
Link

Contact

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