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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> N-Benzyl-N-Demethylpronqodine A

Inhibitory activity to indoleamine-2,3-dioxygenase (IDO) N-Benzyl-N-Demethylpronqodine A

Date：November 17 2025Web Page No：520111

N-Benzyl-N-Demethylpronqodine A is an analog of Pronqodine A¹⁾ and has a quinone structure with benzyl group. This bioactive compound showed stronger inhibitory activity to Indoleamine-2,3-Dioxygenase (IDO) than pronqodine A (IC₅₀＝83.3±2.9 nM).²⁾
* This product is for research use only.

N-Benzyl-N-DemethylpronqodineA-Structure

Structure of N-Benzyl-N-Demethylpronqodine A (#17787)

Specification
Application Note
Reference
Product Information

Specification

CAS#	1810092-90-0
Molecular Formula	C₁₄H₁₀N₂O₂S
Molecular Weight	270.306
Purity	>98% (HPLC)
Solubility	Soluble in MeOH, and DMSO. Insoluble in hexane.

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Application Note

This compound has stronger inhibitory activity to Indoleamine-2,3-Dioxygenase (IDO) than pronqodine A (IC₅₀＝83.3±2.9 nM).²⁾
Pronqodine A and N-Benzyl-N-Demethylpronqodine A were good substrates for NAD(P)H quinone oxidoreductase 1 (NQO1) and were rapidly reduced to unstable hydroquinones that spontaneously undergo autoxidation back to the parent quinone.^1,2)

*Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Nakae, K., et al., J. Nat. Prod., 76(4), 510-515(2013). [PMID:23425216]
Blunt, C. E., et al., Angew. Chem. Int. Ed. Engl., 54(30), 8740-8745(2015). [PMID:26096359]

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Product Information

[Date : November 18 2025 00:13]

Detail Product Name Product Code Supplier Size Price

N-Benzyl-N-demethylpronqodine A <Indoleamine 2,3-dioxygenase (IDO) inhibitor>
DatasheetThis may not be the latest data sheet. 17787 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 270.306 Purity : >98% (HPLC) Molecular Formula : C14H10N2O2S Solubility : Soluble in MeOH, and DMSO. Insoluble in hexane. N-Benzyl-N-Demethylpronqodine A is an analog of pronqodine A (Product code: 17684). This bioactive compound showed stronger inhibitory activity to Indoleamine-2,3-Dioxygenase (IDO) than pronqodine A.
Storage	-20°C	CAS	1810092-90-0
Link

[Date : November 18 2025 00:13]

N-Benzyl-N-demethylpronqodine A <Indoleamine 2,3-dioxygenase (IDO) inhibitor>

DatasheetThis may not be the latest data sheet.

Product Code: 17787
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 270.306 Purity : >98% (HPLC) Molecular Formula : C14H10N2O2S Solubility : Soluble in MeOH, and DMSO. Insoluble in hexane. N-Benzyl-N-Demethylpronqodine A is an analog of pronqodine A (Product code: 17684). This bioactive compound showed stronger inhibitory activity to Indoleamine-2,3-Dioxygenase (IDO) than pronqodine A.
Storage	-20°C	CAS	1810092-90-0
Link

Contact

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