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HOME> Products> Natural and Chemical compound> Other natural compound> Foroxymithine [CAS: 100157-28-6]

Selective inhibitor of angiotensin-converting enzyme (ACE) Foroxymithine [CAS: 100157-28-6]

Date：August 06 2025Web Page No：520097

Foroxymithine was isolated from culture filtrate of Streptomyces as an inhibitor of angiotensin-converting enzyme (ACE, dipeptidyl carboxypeptidase).¹⁾
This compound is a potent chelator of ferric ion (Fe³⁺) as a siderophore. Utilizing this property, there was an example to protect an administrated compound from the ferric iron in serum.²⁾ A variety of compounds have been reported as siderophores isolated from Streptomyces, it was also reported that the bacteria might utilize foroxymithine in order to obtain ferrous and ferric irons, and take an advantage to survive in their habitat environment.³⁾
* This product is for research use only.

Structure of Foroxymithine (#16968)

Specification
Application Note
Reference
Product Information

Specification

CAS#	100157-28-6
Molecular Formula	C₂₂H₃₇N₇O₁₁
Molecular Weight	575.576
Purity	>95% (HPLC)
Solubility	Soluble in H₂O, DMSO, and MeOH

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Application Note

Among peptidases, foroxymithine selectively inhibited angiotensin-converting enzyme (ACE) derived from bovine lung homoginates (IC₅₀=7 μg/ml).¹⁾
Oral administration of foroxymithine (25 mg/kg, 50 mg/kg) to spontaneously hypertensive rats (SHR) resulted in a reduction of systolic blood pressure. The maximum value was decreased in 1-3 hours after dosing.¹⁾
Erbstatin is a tyrosine kinase inhibitor which is degraded in the presence of ferric irons (Fe³⁺) in serum. When used in assays together with erbstatin, foroxymithine suppressed the iron-induced degradation of the tyrosine kinase inhibitor.²⁾

■List of peptidases inhibited by foroxymithine (cited from reference #1)

Peptidase	IC₅₀（μg/ml）
Angiotensin-converting enzyme	7.0
Carboxypeptidase A and B	＞100
Aminopeptidase A and B	＞100
Dipeptidyl aminopeptidaseⅣ	＞100
Chymostatin	＞100

* IC₅₀ of the product was not verified. The values shown on the table were cited from the reference.

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Reference

Umezawa, H., et al., J. Antibiotics, 38 (12), 1813~1815 (1985). [PMID:3005216]
Imoto, M., et al., Jpn. J. Cancer Res., 78 (4), 329~332 (1987). [PMID:3108212]
Shepherdson, E.M.F. and Elliot, M.A., Proc. Natl. Acad. Sci. USA., 119 (40), e2211052119 (2022). [PMID:36161918]

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Product Information

[Date : August 08 2025 00:08]

Detail Product Name Product Code Supplier Size Price

Foroxymithine, ACE Inhibitor, Hypotensiven, Siderophore
DatasheetThis may not be the latest data sheet. 16968 IMCInstitute of Microbial Chemistry 5 mg $500

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Description	M.W.: 575.576 Purity : >95% (HPLC) Molecular Formula : C22H37N7O11 Solubility : Soluble in H2O, DMSO, MeOH Foroxymithine is a specific inhibitor of angiotensin-converting enzyme (ACE, dipeptidyl carboxypeptidase). This natural compound is known as a siderophore and a potent chelator of ferric ion (Fe3+) especially.
Storage	-20°C	CAS	100157-28-6
Link

[Date : August 08 2025 00:08]

Foroxymithine, ACE Inhibitor, Hypotensiven, Siderophore

DatasheetThis may not be the latest data sheet.

Product Code: 16968
Supplier: IMC
Size: 5mg
Price: $500

Description	M.W.: 575.576 Purity : >95% (HPLC) Molecular Formula : C22H37N7O11 Solubility : Soluble in H2O, DMSO, MeOH Foroxymithine is a specific inhibitor of angiotensin-converting enzyme (ACE, dipeptidyl carboxypeptidase). This natural compound is known as a siderophore and a potent chelator of ferric ion (Fe3+) especially.
Storage	-20°C	CAS	100157-28-6
Link

Contact

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