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HOME> Products> Natural and Chemical compound> Other natural compound> Lavendamycin [CAS: 81645-09-2]

Bioactive compound harboring antibacterial and antitumor activities Lavendamycin [CAS: 81645-09-2]

Date：July 29 2025Web Page No：520096

Lavendamycin is a bioactive compound harboring a quinoline quinone core similar to streptonigrin and was isolated from fermentation broth of Streptomyces.¹⁾ It was known that this compound had significant antimicrobial and antitumor activities. However, further development of lavendamycin as an anticancer agent was halted because of the poor aqueous solubility.²⁾ There were many papers reporting structure-activity relationship and it was recently reported that lavendamycin inhibited cell lines of T-cell acute lymphoid leukemia (T-ALL).⁵⁾ Therefore, this compound has attracted attention in biological research field.
* This product is for research use only.

Structure of Lavendamycin (#16734)

Specification
Application Note
Reference
Product Information

Specification

CAS#	81645-09-2
Molecular Formula	C₂₂H₁₄N₄O₄
Molecular Weight	398.378
Purity	>90% (HPLC)
Solubility	Soluble in DMSO

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Application Note

Survival rate of mice which inoculated with bleomycin sensitive cell line P-388-J was increased their survival rate up to 30% by administration of lavendamycin.¹⁾ (The blenomycin sensitive P-388-J was derived from mouse lymphoid tumor cell line P-388.)
Although lavemdamycin inhibited growth of T-ALL cell line CCRF-CEM at the low concentration range (IC₅₀: 0.02 μM), it did not growth of B-cell lymphoma cell line Raji.⁵⁾
This compound had inhibitory activity of bacterial and fungal growth, but it especially showed strong growth inhibition to Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum canis.¹⁾

■ Antibacterial activity of lavendamycin (from reference #1)

Bacterial species	MIC（μg/ml）
Trichophyton rubrum	0.5
Trichophyton mentagrophytes	0.5
Microsporum canis	0.25

* Biological activity of the product was not verified. The values shown on the table were cited from the reference paper.

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Reference

Balitz, D.M., et al., J. Antibiotics, 35 (3), 259~265 (1982). [PMID:7076573]
Fang, Y., et al., Mol. Cancer Ther., 2 (6), 517~526 (2003). [PMID:12813130]
Hassani, M., et al., J. Med. Chem., 48 (24), 7733~7749 (2005). [PMID:16302813]
Seradj, H., et al., Org. Lett., 6 (4), 473~476 (2004). [PMID:14961601]
Miyashita, K., et al., Cancer Sci., 114 (10), 4032~4040 (2023). [PMID:37522388]

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Product Information

[Date : August 29 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Lavendamycin <Antibacterial, Antitumor>
DatasheetThis may not be the latest data sheet. 16734 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 398.378 Purity : >90% (HPLC) Molecular Formula : C22H14N4O4 Solubility : Soluble in DMSO Lavendamycin is a bioactive compound harboring antibacterial and antitumor activities, which was isolated from Streptomyces. It was reported that this compound inhibited growth of T-cell acute lymphoblastic leukemia cell line (T-ALL).
Storage	-20°C	CAS	81645-09-2
Link

[Date : August 29 2025 00:07]

Lavendamycin <Antibacterial, Antitumor>

DatasheetThis may not be the latest data sheet.

Product Code: 16734
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 398.378 Purity : >90% (HPLC) Molecular Formula : C22H14N4O4 Solubility : Soluble in DMSO Lavendamycin is a bioactive compound harboring antibacterial and antitumor activities, which was isolated from Streptomyces. It was reported that this compound inhibited growth of T-cell acute lymphoblastic leukemia cell line (T-ALL).
Storage	-20°C	CAS	81645-09-2
Link

Contact

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