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HOME> Products> Natural and Chemical compound> Other natural compound> MC-1 [CAS: 39051-96-2]

Inhibitor of Angiogenesis MC-1 [CAS: 39051-96-2]

Date：July 08 2025Web Page No：520092

MC-1 which consists of an isocoumarin backbone is one of the derivatives from cytogenin (#16331) which was discovered from Streptoverticillium eurocidium. It was reported that this compound showed inhibitory activity against angiogenesis in mice, which is similar level to cytogenin. On the other hand, it had higher stability than cytogenin in vivo.¹⁾ Among metabolites of cytogenin in mice, MC-1 has a side-chain substituted from alcohol to carboxylate.
Intriguingly, it was also reported that MC-1 was isolated from Aspergillus ochraceus²⁾ which is known to produce ochratoxin, and Aspergillus sp.³⁾ which is a mangrove endophytic fungus.
* This product is for research use only.

Structures of MC-1 and Cytogenin

Specification
Application Note
Reference
Product Information

Specification

CAS#	39051-96-2
Molecular Formula	C₁₁H₈O₆
Molecular Weight	236.179
Purity	>98% (HPLC)
Solubility	Soluble in DMSO and MeOH

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Application Note

MC-1 which is one of the metabolites of cytogenin was indicated to be highly stable in vivo because it was excreted in urine without being metabolized by glucuronic acid conjugation.¹⁾
It was reported that MC-1 has a similar activity of anti-arthritis in type II collagen-induced arthritic mice by oral administration (20 mg/kg).¹⁾
In a mouse dorsal air sac assay, MC-1 inhibited S-180 tumor cells induced angiogenesis, which was similar level of the cytogenin’s inhibitory activity.¹⁾

Compound Name	Anti-arthritis Inhibitory Activity (%)	Anti-angiongenesis Inhibitory Activity (%)
MC-1	32.6%	50%
Cytogenin	38.1%	60%

* Biological activity of the product was not verified. The values shown on the table were cited from the reference paper.

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Reference

Matsumoto, N., et al., J. Antibiotics, 54 (3), 285~296 (2001). [PMID:11372785]
Yamazaki, M., et al., Chem. Pharm. Bull., 20 (10), 2276~2278 (1972). [DOI:10.1248/cpb.20.2276]
Feng, A., et al., Nat. Prod. Res., 38 (14), 2474~2479 (2024). [PMID:36815551]

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Product Information

[Date : July 15 2025 00:07]

Detail Product Name Product Code Supplier Size Price

MC-1 <Angiogenesis Inhibitor>
DatasheetThis may not be the latest data sheet. 16479 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 236.179 Purity : >98% (HPLC) Molecular Formula : C11H8O6 Solubility : Soluble in MeOH, and DMSO, MC-1 is one of the metabolites of Cytogenin developed from Streptoverticillium. It was reported that this compound showed inhibitory activity against angiogenesis in mice, which is similar level to Cytogenin. On the other hand, it had higher stability than Cytogenin in vivo.
Storage	-20°C	CAS	39051-96-2
Link

[Date : July 15 2025 00:07]

MC-1 <Angiogenesis Inhibitor>

DatasheetThis may not be the latest data sheet.

Product Code: 16479
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 236.179 Purity : >98% (HPLC) Molecular Formula : C11H8O6 Solubility : Soluble in MeOH, and DMSO, MC-1 is one of the metabolites of Cytogenin developed from Streptoverticillium. It was reported that this compound showed inhibitory activity against angiogenesis in mice, which is similar level to Cytogenin. On the other hand, it had higher stability than Cytogenin in vivo.
Storage	-20°C	CAS	39051-96-2
Link

Contact

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