Bioactive compound harboring anti-tumor and anti-angiogenesis activities NM-3 [CAS: 181427-78-1]

NM-3 harboring isocoumarin backbone is a synthesized derivative of cytogenin (#16331), which is redesigned to have biologically stable structure. A variety of the derivatives were examined and concluded that NM-3 had the most superior pharmacological activity than other derivatives.^{1, 3)} In addition, it was reported that oral administration of NM-3 to mice showed dose-dependently suppression of angiogenesis.³⁾
* This product is for research use only.

Structure of NM-3 (#16332)

Cytogenin was first isolated from fermentation broth of Streptoverticillium eurocidicum as an immunomodulative antitumor substance ⁷⁾, and had an anti-inflammatory activity against collagen-induced arthritic model in mice.^{2, 3)}
However, it was reported that administrated cytogenin to mice was converted to glucuronate or sulfate conjugated forms with low activity easily, or another compound (MC-1) which was substituted to carbonate at the position 3 carbon in cytogenin, during metabolism. This phenomenon caused a decrease in the activity of cytogenin in animal testing. In order to prevent generation of the conjugated forms, O-acyl, and O-alkyl derivatives, and other analogues harboring carbonate at the position 3 sidechain. NM-3 is the derivative showing the best pharmacological activity among them.