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HOME> Products> Natural and Chemical compound> Other natural compound> Actinobolin (Sulfate) [CAS: 18802-17-0]

Bioactive compound to inhibit protein synthesis Actinobolin (Sulfate) [CAS: 18802-17-0]

Date：June 24 2025Web Page No：520087

Actinobolin is a bioactive compound harboring antibiotic activity, which was isolated from Streptomyces.¹⁾ Actinobolin is able to inhibit protein synthesis in both bacteria²⁾ and mammalian cells.^{3, 4)} It was also reported that this compound expressed inhibitory activity to bacteria associated with periodontal diseases⁵⁾ and immunosuppression.⁶⁾
It is also known that Bactobolin which was isolated from Psendonionas has a similar structure of Actinobolin.
* This product is for research use only.

Structure of Actinobolin (Sulfate) (#15172)

Specification
Application note
Reference

Specification

CAS#	18802-17-0
Molecular Formula	C₁₃H₂₀N₂O₆･1/2H₂SO₄
Molecular Weight	349.347
Purity	>98% (HPLC)
Solubility	Soluble in H₂O, MeOH, and DMSO

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Application note

Actinobolin inhibited protein synthesis in Escherichia coli, which the inhibitory mechanism was different of other inhibitors such as Chloramphenicol and Sparsomycin.²⁾
Actinobolin inhibited synthesis of both DNA and protein in mouse Adenocarcinoma 755 cells, both in vivo and in cell culture. It was suggested that the compound could compete aminoacyl-tRNA to inhibit protein synthesis.³⁾
Actinobolin expressed inhibitory activity to bacteria associated with periodontal diseases such as Bacteroides melaninogenicus, Fusobacterium fusiforme, Leptotrichia buccalis, and Veillonella parvula.⁵⁾
This compound expressed immunosuppressing activity to experimental autoimmune myasthenia gravis (EAMG).⁶⁾
As shown at the table below, the compound had inhibitory activity to protein synthesis in E. coli and mammalian cells.⁴⁾

■ Inhibitory activity of Actinobolin against protein synthesis from Reference #4

Biological activity		Activity value
E. coli	Reported MIC (Minimum Inhibitory Concentration)	1.7×10^-4 M
E. coli	Inhibition of protein synthesis (ID₅₀)	3×10^-5 M
Mouse L1210 cell line	Inhibition of cell growth (ID₅₀)	1.2×10^-4 M
Mouse L1210 cell line	Inhibition of protein synthesis (ID₅₀)	4×10^-4 M
Rabbit reticulocytes (Cell free)	Inhibition of hemoglobin synthesis (ID₅₀)	1×10^-3 M

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Reference

Haskell, T.H., et al., US Patent, 3043830 (1962).
Hunt, D.E., et al., Can. J. Microbiol., 12 (3), 515～520 (1966). [PMID:5336183]
Smithers, D., et al., Mol. Pharmacol., 5 (5), 433～445 (1969). [PMID:5823760]
Hori, M., et al., J. Antibiotics, 34 (4), 465～468 (1981). [PMID:7196909]
Armstrong, P.J. Jr. and Hunt, D.E., Appl. Microbiol., 23 (1), 88～90 (1972). [PMID:5059624]
Ishigaki, Y., et al., J. Neurol. Sci., 112 (1-2), 209～215 (1992). [PMID:1469434]

[Date : June 24 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Actinobolin (sulfate) <Protein and DNA Synthesis Inhibitor>
DatasheetThis may not be the latest data sheet. 15172 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 349.347 Purity : >98% (HPLC) Molecular Formula : C13H20N2O6･1/2H2SO4 Solubility : Soluble in H2O, DMSO, and MeOH Actinobolin is a biological compound harboring antibacterial activity. It was reported that the compound inhibited protein synthesis in bacteria and mammalian cells.
Storage	-20°C	CAS	18802-17-0
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[Date : June 24 2025 00:07]

Actinobolin (sulfate) <Protein and DNA Synthesis Inhibitor>

DatasheetThis may not be the latest data sheet.

Product Code: 15172
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 349.347 Purity : >98% (HPLC) Molecular Formula : C13H20N2O6･1/2H2SO4 Solubility : Soluble in H2O, DMSO, and MeOH Actinobolin is a biological compound harboring antibacterial activity. It was reported that the compound inhibited protein synthesis in bacteria and mammalian cells.
Storage	-20°C	CAS	18802-17-0
Link

Contact

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