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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Piericidin A1

NADH:Ubiquinone oxidoreductase (Complex I) inhibitor Piericidin A1

Date：June 13 2025Web Page No：520084

Piericidin A1 is isolated from the fermentation broth of Streptomyces and known as a specific inhibitor of respiratory chain in electron transport system¹⁾. The bioactive compound was reported as “Piericidin A” initially, the detailed structural analysis revealed that the compound actually had 4 different analogues. From this report, the initially identified compound was named as Piericidin A1.²⁾
It was reported that Piericidin A1 inhibited Complex I (NADH:ubiquinone oxidoreductase) in the respiratory chain by targeting to the ubiquinone binding site.^{3, 4)} In addition, it is suggested that Piericidin A1 prevents up-regulation of GRP78 and exhibits cytotoxicity in glucose-deprived HT29 cells (etoposide-resistant).⁵⁾
Piericidin A1-Structure

Structure of Piericidin A1 (#14688)

Specification
Application Note
Reference

Specification

CAS#	2738-64-9
Molecular Formula	C₂₅H₃₇NO₄
Molecular Weight	415.574
Purity	>90% (HPLC)
Supplied as	1 mg/ml solution in EtOH^＊
Solubility	Soluble in MeOH, EtOH, hexane, DMSO, and DMF Hardly soluble in H₂O

＊ Piericidin A1 is an oil-like compound at room temperature. This product will be supplied as 3 vials of 1mL solution (1mg/mL) in EtOH. It is recommended a stock solution should be protected from light and use within a couple of days.

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Application Note

It was reported that Piericidin A1 inhibited respiratory complex I (NADH:ubiquinone oxidoreductase) by targeting to the binding site of ubiquinone (IC₅₀: 3.7 nM).^{3, 4)}
It was reported that Piericidin A1 prevented up-regulation of GRP78 which acts as endoplasmic reticulum (ER) chaperon and exhibits cytotoxicity in glucose-deprived HT29 cells (etoposide-resistant).⁵⁾

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Reference

Tamura, S., et al., Agr. Biol. Chem., 27 (8), 576~582 (1963). [DOI:10.1271/bbb1961.27.576]
Yoshida, S., et al., Agr. Biol. Chem., 41 (5), 849~853 (1977). [DOI:10.1271/bbb1961.41.849]
Okun, J.G., et al., J. Biol. Chem., 274 (5), 2625~2630 (1999). [PMID:9915790]
Zhou, X., et al., J. Antibiot., 69 (6), 582~593 (2016). [PMID:27301663]
Hwang, J.H., et al., J. Cell. Physiol., 215 (1), 243~250 (2008). [PMID:17941090]

[Date : June 24 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Piericidin A1, NADH:Ubiquinone Oxidoreductase Inhibitor
DatasheetThis may not be the latest data sheet. 14688 IMCInstitute of Microbial Chemistry 3x1 mg $500

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Description	M.W.: 415.574 Purity : >90％ (HPLC) Molecular Formula : C25H37NO4 Supplied as: EtOH solution (1 mg/mL) Solubility : Soluble in MeOH, EtOH, hexane, and DMF, Hardly soluble in H2O. Piericidin A1 is a bioactive compound which is known as a specific inhibitor of the respiratory chain in the electron transport system. This compound inhibits functions of the respiratory chain by targeting to the ubiquinone binding site on the respiratory complex I (also known as NADH:ubiquinone oxidoreductase).
Storage	-20°C,Dark Strage	CAS	2738-64-9
Link	Bioactive Compounds

[Date : June 24 2025 00:07]

Piericidin A1, NADH:Ubiquinone Oxidoreductase Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 14688
Supplier: IMC
Size: 3x1mg
Price: $500

Description	M.W.: 415.574 Purity : >90％ (HPLC) Molecular Formula : C25H37NO4 Supplied as: EtOH solution (1 mg/mL) Solubility : Soluble in MeOH, EtOH, hexane, and DMF, Hardly soluble in H2O. Piericidin A1 is a bioactive compound which is known as a specific inhibitor of the respiratory chain in the electron transport system. This compound inhibits functions of the respiratory chain by targeting to the ubiquinone binding site on the respiratory complex I (also known as NADH:ubiquinone oxidoreductase).
Storage	-20°C,Dark Strage	CAS	2738-64-9
Link	Bioactive Compounds

Contact

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