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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Benastatin B

Glutathione S-Transferase (GST) Inhibitor Benastatin B

Date：July 03 2020Web Page No：520051

Benastatin B is isolated from the culture broth of Streptomyces sp. MI384-DF12 as an inhibitor of glutathione S-transferase (GST).^1,2)

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Specification
Application Note
Reference

Specification

CAS#	138968-86-2
Molecular Formula	C₃₀H₃₀O₇
Molecular Weight	502.563
Source	Streptomyces sp. MI384-DF12
Purity	> 95% (HPLC)
Solubility	Soluble in DMSO. Poorly soluble in MeOH, Acetone, EtOAc. Insoluble in H₂O

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Application Note

The inhibition of benastatin B against GST is competitive with 3,4-dichloronitrobenzene (Ki:3.7×10^-6 M), and noncompetitive with glutathione (Ki:4.2×10^-6 M).
Benastatin B has activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).¹⁾
It was more potent than benastatin A against Micrococcus luteus (MIC=3.9 μM).³⁾
In rat basophilic leukemia-derived RBL-2H3 cells, which is an evaluation model for inhibition of immediate-type allergic hypersensitivity reactions, benastatin B inhibited IgE-stimulated β-hexosaminidase release more strongly than benastatin A (IC50=19 μM).³⁾

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Aoyagi, T. et al., J. Antibiot., 45(9), 1385-1390(1992). [PMID:1429222]
Aoyama, T. et al., J. Antibiot., 45(9), 1391-1396(1992). [PMID:1429223]
Kawahara, T. et al., J. Antibiot., 77(7), 471-474(2024). [PMID:38664572]

[Date : May 19 2026 00:10]

Detail Product Name Product Code Supplier Size Price

Benastatin B, Glutathione S-Transferase (GST) Inhibitor
DatasheetThis may not be the latest data sheet. 14653 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 502.563 Purity : > 95％ (HPLC) Molecular Formula : C30H30O7 Solubility : Soluble in DMSO, Poorly soluble in MeOH, Acetone, EtOAc, Insoluble in H2O. Benastatin B exhibited competitive inhibitory activity with 3,4-dichloronitrobenzene (Ki:3.7×10^-6 M), and noncompetitive with glutathione (Ki:4.2×10^-6 M). In addition, this compound also has anti-bacterial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Storage	-20°C	CAS	138968-86-2
Link	Bioactive Compounds

[Date : May 19 2026 00:10]

Benastatin B, Glutathione S-Transferase (GST) Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 14653
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 502.563 Purity : > 95％ (HPLC) Molecular Formula : C30H30O7 Solubility : Soluble in DMSO, Poorly soluble in MeOH, Acetone, EtOAc, Insoluble in H2O. Benastatin B exhibited competitive inhibitory activity with 3,4-dichloronitrobenzene (Ki:3.7×10^-6 M), and noncompetitive with glutathione (Ki:4.2×10^-6 M). In addition, this compound also has anti-bacterial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Storage	-20°C	CAS	138968-86-2
Link	Bioactive Compounds

Contact

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