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HOME> Products> Natural and Chemical compound> Inostamycin A (sodium salt)

Inhibitor of Phosphatidylinositol Turnover Inostamycin A (sodium salt)

Date：July 03 2020Web Page No：520050

Inostamycin A is isolated from the culture fluid of Streptomyces sp. MH816-AF15 and inhibits cytidine diphosphodiacylglycerol (CDP-DG): inositol transferase ¹⁾.

Specification
Mechanism
Application Note
Reference

Specification

CAS#	1884611-95-3
Molecular Formula	C₃₈H₆₇O₁₁ Na
Molecular Weight	722.933
Source	Streptomyces sp. MH816-AF15
Purity	> 90% (Quantitative NMR)
Solubility	Soluble in DMSO, DMF and CHCl₃. Poorly soluble in H₂O

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Mechanism

Phosphatidylinositol 2-phosphate (PIP₂), generated from phosphatidylinositol (PI) present in the cell membrane, is degraded by phospholipase C (PLC) to inositol triphosphate (IP₃) and diacylglycerol (DG), and IP₃ is converted to inositol (I). The inositol (I) is bound to CDP-DG and PI is resynthesized. This metabolic turnover is called the inositol phospholipid turnover. IP₃ generated by this turnover releases Ca²⁺ from the endoplasmic reticulum, and the Ca²⁺ and DG activate protein kinase C (PKC), which phosphorylates various intracellular proteins to activate proliferation signals and cancer malignancy signals.
Inostamycin A inhibits the synthesis of PI from I and CDP-DG in inositol-phospholipid-turnover and arrests cell-cycle in G1 phase, thereby inhibiting cell proliferation ²⁾.

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Application Note

Inhibited in vitro CDP-DG: inositol transferase activity of the A431 cell membrane, the IC₅₀ was about 0.02 μg/ml ¹⁾
Inhibited EGF-induced inositol incorporation into inositol lipids with an IC₅₀ of about 0.5 μg/ml in the A431 cell assay system ²⁾
Showed antimicrobial activities against Gram-positive bacteria and cytocidal activity against srk-NIH-3T3 cell with IC₅₀ value of 0.07 μg/ml ³⁾
Potenciated colchitine cytotoxicity toward KB-C4 cells at 3 μg/ml ⁴⁾
Enhanced the cytotoxic effect of Taxol on small cell lung cancer cells ⁵⁾
Caused Ms-1 cell to accumulate in the G1 phase at 0.1 μg/ml and induces morphological apoptosis at high concentration (0.3 μg/ml) ⁶⁾

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Reference

Imoto M. et al. J. Biochem., 112, 299～302 (1992)
Imoto M. et al. J. Nat. Prod., 53(4), 825～829 (1990)
Odai H. et al. J. Antibiot., 47(8), 939～941 (1994)
Kawada M. et al. J. Antibiot., 45(4), 556～562 (1992)
Imoto M. et al. Jpn. J. Cancer Res., 89(9), 315～322 (1998)
Simizu S. et al. Jpn. J. Cancer Res., 89(9), 970～976 (1998)

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Inostamycin A (Sodium Salt), Antitumor
DatasheetThis may not be the latest data sheet. 14652 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	Supplied as sodium salt
Storage	-20°C	CAS	1884611-95-3 (sodium salt), 129905-10-8 (salt free form)
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Inostamycin A (Sodium Salt), Antitumor

DatasheetThis may not be the latest data sheet.

Product Code: 14652
Supplier: IMC
Size: 1mg
Price: $500

Description	Supplied as sodium salt
Storage	-20°C	CAS	1884611-95-3 (sodium salt), 129905-10-8 (salt free form)
Link	Bioactive Compounds

Contact

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