inhibitory and anti-HIV effects on leukemia L1210 cells Oxanosine
Date:July 03 2020Web Page No:520045
Oxanosine isolated from the culture broth of Streptomyces capreolus MG265-CF3 was reported as a novel nucleoside. The structure of oxanosine is similar to guanine, a nucleobase, with the nitrogen (N) next to the carbonyl group changs to oxygen (O), and the sugar has the same ribose structure as RNA by X-ray analysis 1). Even in recent years, studies on oxanosine derivatives have been reported 2).

Specification
CAS# | 80394-72-5 |
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Molecular Formula | C10H12N4O6 |
Molecular Weight | 284.227 |
Source | Streptomyces capreolus MG265-CF3 |
Purity | > 98% (HPLC) |
Solubility | Soluble in H2O, MeOH, DMSO Insoluble in CHCl3 |
Application Note
- Antibacterial activity against Eschericia.coli K-12.3)
- Cell growth inhibitory activity against HeLa cells (IC50:32 μg/ml).3)
- Inhibits proliferation of mouse leukemia L1210 cells (Ki:7.4×10-4 M).3)
- Competitive inhibitor of GMP synthetase (Ki:7.4×10-4 M).4)
- Induces a reversion toward the normal phenotype of K-ras-transformed rat kidney cells.5)
- Inhibits HIV-1 replication against CEM cells and U937 cells (EC50:7.0 μg/ml(CEM), EC50:27 μg/ml(U937)).6)
Reference
- Nakamura H. et al. J. Antibiot., 34(9), 1219~1221(1981).
- Yu R. et al. Chem.Res.Toxicol., 32(3), 456~466(2019).
- Shimada N. et al. J. Antibiot., 34(9), 1216~1218(1981).
- Yagisawa N. et al. J. Antibiot., 35(6), 755~759(1982).
- Itoh O. et al. Cancer Res., 49(4), 996~1000(1989).
- Saito Y. et al. J. Antibiot., 53(3), 309~313(2000).

[Date : April 25 2025 00:06]
Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
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Oxanosine, Antitumor, GMP Synthase Inhibitor DatasheetThis may not be the latest data sheet. |
00762 | IMCInstitute of Microbial Chemistry | 1 mg | $500 | |||||||||||||||||||||||||||||||
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[Date : April 25 2025 00:06]
Oxanosine, Antitumor, GMP Synthase Inhibitor
DatasheetThis may not be the latest data sheet.
- Product Code: 00762
- Supplier: IMC
- Size: 1mg
- Price: $500
Description | |||
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Storage | -20°C | CAS | 80394-72-5 |
Link |
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