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inhibitory and anti-HIV effects on leukemia L1210 cells Oxanosine

Date:July 03 2020Web Page No:520045

Oxanosine isolated from the culture broth of Streptomyces capreolus MG265-CF3 was reported as a novel nucleoside. The structure of oxanosine is similar to guanine, a nucleobase, with the nitrogen (N) next to the carbonyl group changs to oxygen (O), and the sugar has the same ribose structure as RNA by X-ray analysis 1). Even in recent years, studies on oxanosine derivatives have been reported 2).

Oxanosine (Inhibitor for GMP synthetase and inosine monophosphate (IMP) dehydrogenase)

Specification

CAS#80394-72-5
Molecular FormulaC10H12N4O6
Molecular Weight284.227
SourceStreptomyces capreolus MG265-CF3
Purity> 98% (HPLC)
SolubilitySoluble in H2O, MeOH, DMSO
Insoluble in CHCl3

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Application Note

  • Antibacterial activity against Eschericia.coli K-12.3)
  • Cell growth inhibitory activity against HeLa cells (IC50:32 μg/ml).3)
  • Inhibits proliferation of mouse leukemia L1210 cells (Ki:7.4×10-4 M).3)
  • Competitive inhibitor of GMP synthetase (Ki:7.4×10-4 M).4)
  • Induces a reversion toward the normal phenotype of K-ras-transformed rat kidney cells.5)
  • Inhibits HIV-1 replication against CEM cells and U937 cells (EC50:7.0 μg/ml(CEM), EC50:27 μg/ml(U937)).6)

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Reference

  1. Nakamura H. et al. J. Antibiot., 34(9), 1219~1221(1981).
  2. Yu R. et al. Chem.Res.Toxicol., 32(3), 456~466(2019).
  3. Shimada N. et al. J. Antibiot., 34(9), 1216~1218(1981).
  4. Yagisawa N. et al. J. Antibiot., 35(6), 755~759(1982).
  5. Itoh O. et al. Cancer Res., 49(4), 996~1000(1989).
  6. Saito Y. et al. J. Antibiot., 53(3), 309~313(2000).

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[Date : June 20 2024 00:07]

Detail Product Name Product Code Supplier Size Price
Oxanosine,Antitumor,GMP Synthase Inhibitor
DatasheetThis may not be the latest data sheet.
00762 IMCInstitute of Microbial Chemistry 1 mg $500

Description
Storage -20°C CAS 80394-72-5
Link

Bioactive Compounds

[Date : June 20 2024 00:07]

Oxanosine,Antitumor,GMP Synthase Inhibitor


  • Product Code: 00762
  • Supplier: IMC
  • Size: 1mg
  • Price: $500

Description
Storage -20°C CAS 80394-72-5
Link

Bioactive Compounds

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