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HOME> Products> Natural and Chemical compound> Oxanosine

inhibitory and anti-HIV effects on leukemia L1210 cells Oxanosine

Date：July 03 2020Web Page No：520045

Oxanosine isolated from the culture broth of Streptomyces capreolus MG265-CF3 was reported as a novel nucleoside. The structure of oxanosine is similar to guanine, a nucleobase, with the nitrogen (N) next to the carbonyl group changs to oxygen (O), and the sugar has the same ribose structure as RNA by X-ray analysis ¹⁾. Even in recent years, studies on oxanosine derivatives have been reported ²⁾.

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Oxanosine (Inhibitor for GMP synthetase and inosine monophosphate (IMP) dehydrogenase)

Oxanosine (Inhibitor for GMP synthetase and inosine monophosphate (IMP) dehydrogenase)

Specification
Application Note
Reference

Specification

CAS#	80394-72-5
Molecular Formula	C₁₀H₁₂N₄O₆
Molecular Weight	284.227
Source	Streptomyces capreolus MG265-CF3
Purity	> 98% (HPLC)
Solubility	Soluble in H₂O, MeOH, DMSO Insoluble in CHCl₃

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Application Note

Antibacterial activity against Eschericia.coli K-12.³⁾
Cell growth inhibitory activity against HeLa cells (IC₅₀:32 μg/ml).³⁾
Inhibits proliferation of mouse leukemia L1210 cells (Ki:7.4×10^-4 M).³⁾
Competitive inhibitor of GMP synthetase (Ki:7.4×10^-4 M).⁴⁾
Induces a reversion toward the normal phenotype of K-ras-transformed rat kidney cells.⁵⁾
Inhibits HIV-1 replication against CEM cells and U937 cells (EC₅₀:7.0 μg/ml(CEM), EC₅₀:27 μg/ml(U937)).⁶⁾
Oxanosine alone did not affect HIV replication in HIV-infected H9 cells up to 100 μg/ml, in contrast, the compound showed concentration-dependent inhibition of HIV (1~100 μg/ml) without cytotoxicity in the presence of 2′, 3′-dideoxyinosine.⁷⁾

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Nakamura, H. et al., J. Antibiot., 34(9), 1219-1221(1981). [PMID:7328061]
Yu, R. et al., Chem. Res. Toxicol., 32(3), 456-466(2019). [PMID:30746940]
Shimada, N. et al., J. Antibiot., 34(9), 1216-1218(1981). [PMID:7328060]
Yagisawa, N. et al., J. Antibiot., 35(6), 755-759(1982). [PMID:6288649]
Itoh, O. et al., Cancer Res., 49(4), 996-1000(1989). [PMID:2643467]
Saito, Y. et al., J. Antibiot., 53(3), 309-313(2000). [PMID:10819305]
Nakamura, M. et al., Biomed. Pharmacother., 59(1-2), 47-50(2005). [PMID:15740935]

[Date : May 19 2026 00:10]

Detail Product Name Product Code Supplier Size Price

Oxanosine, Antitumor, GMP Synthase Inhibitor
DatasheetThis may not be the latest data sheet. 00762 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 284.23 Purity : > 98％ (HPLC) Molecular Formula : C10H12N4O6 Solubility : Soluble in H2O, Methanol, and DMSO, Insoluble in CHCl3. Inhibitory activity of leukemia L210 : IC50=1.0 μg/ml, Competitive inhibitory activity of GMP synthase : Ki=7.4x10-4 M. Oxanosine was isolated from culture broth of Streptomyces capreolus MG265-CF3 and was reported as a novel nucleoside. It was also reported that this compound has an inhibitory activity of HIV replication and leukemia L1210 cell growth.
Storage	-20°C	CAS	80394-72-5
Link	Bioactive Compounds

[Date : May 19 2026 00:10]

Oxanosine, Antitumor, GMP Synthase Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 00762
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 284.23 Purity : > 98％ (HPLC) Molecular Formula : C10H12N4O6 Solubility : Soluble in H2O, Methanol, and DMSO, Insoluble in CHCl3. Inhibitory activity of leukemia L210 : IC50=1.0 μg/ml, Competitive inhibitory activity of GMP synthase : Ki=7.4x10-4 M. Oxanosine was isolated from culture broth of Streptomyces capreolus MG265-CF3 and was reported as a novel nucleoside. It was also reported that this compound has an inhibitory activity of HIV replication and leukemia L1210 cell growth.
Storage	-20°C	CAS	80394-72-5
Link	Bioactive Compounds

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