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HOME> Products> Natural and Chemical compound> Oxanosine

inhibitory and anti-HIV effects on leukemia L1210 cells Oxanosine

Date：July 03 2020Web Page No：520045

Oxanosine isolated from the culture broth of Streptomyces capreolus MG265-CF3 was reported as a novel nucleoside. The structure of oxanosine is similar to guanine, a nucleobase, with the nitrogen (N) next to the carbonyl group changs to oxygen (O), and the sugar has the same ribose structure as RNA by X-ray analysis ¹⁾. Even in recent years, studies on oxanosine derivatives have been reported ²⁾.

Oxanosine (Inhibitor for GMP synthetase and inosine monophosphate (IMP) dehydrogenase)

Specification
Application Note
Reference

Specification

CAS#	80394-72-5
Molecular Formula	C₁₀H₁₂N₄O₆
Molecular Weight	284.227
Source	Streptomyces capreolus MG265-CF3
Purity	> 98% (HPLC)
Solubility	Soluble in H₂O, MeOH, DMSO Insoluble in CHCl₃

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Application Note

Antibacterial activity against Eschericia.coli K-12.³⁾
Cell growth inhibitory activity against HeLa cells (IC₅₀:32 μg/ml).³⁾
Inhibits proliferation of mouse leukemia L1210 cells (Ki:7.4×10^-4 M).³⁾
Competitive inhibitor of GMP synthetase (Ki:7.4×10^-4 M).⁴⁾
Induces a reversion toward the normal phenotype of K-ras-transformed rat kidney cells.⁵⁾
Inhibits HIV-1 replication against CEM cells and U937 cells (EC₅₀:7.0 μg/ml(CEM), EC₅₀:27 μg/ml(U937)).⁶⁾

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Reference

Nakamura H. et al. J. Antibiot., 34(9), 1219～1221(1981).
Yu R. et al. Chem.Res.Toxicol., 32(3), 456～466(2019).
Shimada N. et al. J. Antibiot., 34(9), 1216～1218(1981).
Yagisawa N. et al. J. Antibiot., 35(6), 755～759(1982).
Itoh O. et al. Cancer Res., 49(4), 996～1000(1989).
Saito Y. et al. J. Antibiot., 53(3), 309～313(2000).

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Oxanosine,Antitumor,GMP Synthase Inhibitor
DatasheetThis may not be the latest data sheet. 00762 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS	80394-72-5
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Oxanosine,Antitumor,GMP Synthase Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 00762
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	80394-72-5
Link	Bioactive Compounds

Contact

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