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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Benastatin A

Glutathione S-Transferase (GST) Inhibitor Benastatin A

Date：July 03 2020Web Page No：520041

Benastatin A is isolated from the culture broth of Streptomyces sp. MI384-DF12 as an inhibitor of glutathione S-transferase (GST).^1,2) The bioactive compound has been reported to inhibit GST class Phi (GSTF), which is involved in detoxication and stress response.³⁾ It has antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).¹⁾

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Specification
Application Note
Reference

Specification

CAS#	138968-85-1
Molecular Formula	C₃₀H₂₈O₇
Molecular Weight	500.547
Source	Streptomyces sp. MI384-DF12
Purity	> 95% (HPLC)
Solubility	Soluble in DMSO. Poorly soluble in MeOH, CHCl₃. Insoluble in H₂O.

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Application Note

The inhibition of benastatin A against GST is competitive with 3,4-dichloronitrobenzene (Ki: 5.0 × 10^-6 M), and noncompetitive with glutathione (Ki: 3.5×10^-6 M).¹⁾
Benastatin A has activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).¹⁾
The compound exhibited an inhibitory activity to Micrococcus luteus (MIC=31.3 μM).⁴⁾
In rat basophilic leukemia-derived RBL-2H3 cells, an evaluation model for inhibition of immediate-type allergic hypersensitivity reactions, the compound inhibited IgE-stimulated β-hexosaminidase release (IC₅₀=79 μM) and suppressed mast cell degranulation.⁴⁾
The compound inhibited OsGSTF5 activity which is rice-derived (IC₅₀=1.36 μM).³⁾

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Aoyagi, T. et al., J. Antibiot., 45(9), 1385-1390(1992). [PMID:1429222]
Aoyama, T. et al., J. Antibiot., 45(9), 1391-1396(1992). [PMID:1429223]
Cho, H.-Y. et al., J. Biochem. Mol. Biol., 40(4), 511-516(2007). [PMID:17669266]
Kawahara, T. et al., J. Antibiot., 77(7), 471-474(2024). [PMID:38664572]

[Date : May 19 2026 00:10]

Detail Product Name Product Code Supplier Size Price

Benastatin A, Glutathione S-Transferase (GST) Inhibitor
DatasheetThis may not be the latest data sheet. 00379 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 500.547 Purity : > 95％ (HPLC) Molecular Formula : C30H28O7 Solubility : Soluble in DMSO, Poorly soluble in MeOH, and CHCl3, Insoluble in H2O. Benastatin A is isolated from the culture broth of Streptomyces sp. MI384-DF12 as an inhibitor of glutathione S-transferase (GST). It was reported that the natural compound has antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Storage	-20°C	CAS	138968-85-1
Link	Bioactive Compounds

[Date : May 19 2026 00:10]

Benastatin A, Glutathione S-Transferase (GST) Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 00379
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 500.547 Purity : > 95％ (HPLC) Molecular Formula : C30H28O7 Solubility : Soluble in DMSO, Poorly soluble in MeOH, and CHCl3, Insoluble in H2O. Benastatin A is isolated from the culture broth of Streptomyces sp. MI384-DF12 as an inhibitor of glutathione S-transferase (GST). It was reported that the natural compound has antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Storage	-20°C	CAS	138968-85-1
Link	Bioactive Compounds

Contact

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