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HOME> Products> Natural and Chemical compound> Pyridindolol

β-Galactosidase Inhibitor Pyridindolol

Date：July 03 2020Web Page No：520040

Pyridindolol is a relatively small natural prodcut (M.W. <260) isolated and purified from Streptomyces alboverticillatus. It was first reported in The Journal of Antibiotics in 1975¹⁾, and there are many articles on the mechanism of action of pyridindolol and its analogues.

Pyridindolol (Inhibitor for β-galactosidase)

Specification
Application Note
Reference

Specification

CAS#	55812-46-9
Molecular Formula	C₁₄H₁₄N₂O₃
Molecular Weight	258.277
Source	Streptomyces alboverticilliatus MD401-C5
Purity	> 90% (HPLC)
Solubility	Soluble in MeOH, EtOH, n-BuOH, DMSO, DMF, 0.5M-HCl. Slightly soluble in H₂O. Insoluble in Benzene, CHCl₃ and Ethyl ether.

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Application Note

Pyridindolol inhibits bovine liver β-galactosidase non-competitively at pH 4.0-5.0 (IC₅₀=7.4 ×10^-6M at pH 4.5).
Pyridindolol has low toxicity to mice (LD₅₀ >500 mg/kg, intraperitoneal injection).¹⁾
Specific inhibitory activity is observed for bovine liver β-galactosidase.²⁾
Simple acetylated analogues show inhibition of cell adhesion factor in HL-60 cells.³⁾

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Reference

Aoyagi T. et al. J. Antibiot., 28(7), 555-557(1975).
Kumagai M. et al. J. Antibiot., 29(7), 696-703(1976).
Kim Y.P. et al. J. Antibiot., 50(3), 189-193(1997).

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

Pyridindolol,β-Galactosidase Inhibitor
DatasheetThis may not be the latest data sheet. 00372 IMCInstitute of Microbial Chemistry 1 mg $500

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Description
Storage	-20°C	CAS	55812-46-9
Link	Bioactive Compounds

[Date : February 15 2024 12:37]

Pyridindolol,β-Galactosidase Inhibitor

DatasheetThis may not be the latest data sheet.

Product Code: 00372
Supplier: IMC
Size: 1mg
Price: $500

Description
Storage	-20°C	CAS	55812-46-9
Link	Bioactive Compounds

Contact

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