100年以上の歴史を持つ多機能低分子化合物 Suramin（AdipoGen社）

• スラミンとは
• スラミンの歴史
• 治療薬として
• 解毒物質として
• さらなる可能性
• 製品ラインナップ
• 価格

スラミンとは

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スラミンの歴史

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治療薬として

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解毒物質として

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さらなる可能性

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製品ラインナップ

品名	CAS No.	分子式	M.W	商品コード
Suramin . hexasodium salt	129-46-4	C51H34N6O23S6 . 6Na	1291.2 . 137.9	AG-CR1-3575
Suramin . sodium salt				AG-CR1-3575V

参考文献

1. Fong, J.S., et al., "Suramin--a potent reversible and competitive inhibitor of complement systems.″ Clin. Exp. Immunol., 10(1), 127～138(1972). [PMID:5017365]
2. Fortes, P.A., et al., "Suramin: a potent ATPase inhibitor which acts on the inside surface of the sodium pump.″ Biochim. Biophys. Acta, 18(2), 262～272(1973). [PMID:4355468]
3. De, C.E., et al., "Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses.″ Cancer Lett., 8(1), 9～22(1979). [PMID:92362]
4. Ono, K., et al., "Differential inhibition of various deoxyribonucleic and ribonucleic acid polymerases by suramin.″ Eur. J. Biochem., 172(2), 349～353(1988). [PMID:2450743]
5. Hensey, C.E., et al., "Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB₂A.″ FEBS Lett., 258(1), 156～158(1989). [PMID:2591531]
6. Freissmuth, M., et al., "Suramin analogues as subtype-selective G protein inhibitors.″ Mol. Pharmacol., 49(4), 602～611(1996). [PMID:8609887]
7. Zhang, Y.L., et al., "Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases.″ J. Biol. Chem., 273(20), 12281～12287(1998). [PMID:9575179]
8. Trieb, K., et al., "Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro.″ Int. J. Biochem. Cell Biol., 35(7), 1066～1070(2003). [PMID:12672477]
9. Monteiro, R.Q., et al., "Suramin interaction with human alpha-thrombin: inhibitory effects and binding studies.″ Int. J. Biochem. Cell Biol., 36(10), 2077～2085(2004). [PMID:15203120]
10. Hill, A.P., et al., "Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites.″ Mol. Pharmacol., 65(5), 1258～1268(2004). [PMID:15102954]
11. Trapp, J., et al., "Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins).″ ChemMedChem, 2(10), 1419～1431(2007). [PMID:17628866]
12. Schuetz, A., et al., "Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.″ Structure, 15(3), 377～389(2007). [PMID:17355872]
13. Feng, Y., et al., "Discovery and mechanistic study of a class of protein arginine methylation inhibitors.″ J. Med. Chem., 53(16), 6028～6039(2010). [PMID:20666457]
14. Morgan, H.P., et al., "The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.″ J. Biol. Chem., 286(36), 31232～31240(2011). [PMID:21733839]
15. El-Kik, C.Z., et al., "Neutralization of Apis mellifera bee venom activities by suramin.″ Toxicon, 67, 55～62(2013). [PMID:23474269]
16. Basavannacharya, C., et al., "Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format.″ Biochem. Biophys. Res. Commun., 453(3), 539～544(2014). [PMID:25281902]
17. Wu, K., et al., "Suramin inhibits cullin-RING E₃ ubiquitin ligases.″ Proc. Natl. Acad. Sci. U S A., 113(14), E2011～E2018(2016). [PMID:27001857]
18. Henß, L., et al., "Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry.″ Virol. J., 13(1), 149(2016). [PMID:27581733]
19. Luo, H., et al., "Suramin is a novel competitive antagonist selective to α1β2γ2 GABA_A over ρ1 GABA_C receptors.″ Neuropharmacology, 141, 148～157(2018). [PMID:30172846]
20. Wang, M., et al., "Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels.″ Future Med. Chem., 10(11), 1301～1317(2018). [PMID:29558821]
21. Paulson, C.N., et al., "The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.″ Open Biol., 9(8), 190117(2019). [PMID:31409229]
22. Lim, J.H., et al., "Evaluating the impact of suramin additive on CHO cells producing Fc-fusion protein.″ Biotechnol. Lett., 41(11), 1255～1263(2019). [PMID:31541331]
23. Salgado-Benvindo, C., et al., "Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle.″ Antimicrob. Agents Chemother., 64(8), e00900～20(2020). [PMID:32513797]
24. Wiedemar, N., et al., "100 Years of Suramin.″ Antimicrob. Agents Chemother., 64(3), e01168～19(2020).[PMID:31844000]
25. Yang, S.N.Y., et al., "High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses.″ Cells, 11(4), 730(2022). [PMID:35203378]
26. Green, J.P., et al., "Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.″ iScience, 26(5), 106758(2023). [PMID:37216118]

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価格

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