抗Human CD19抗体(Anti-Human CD19 antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Human CLL cells
Source	Monoclonal Mouse IgG1 Clone # 4G7-2E3
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CD19.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	0.25 µg/106 cells	See below
CyTOF-ready	Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

Detection of CD19 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD3 epsilon PE‑conjugated Monoclonal Antibody (Catalog # FAB100P) and either (A) Mouse Anti-Human CD19 Monoclonal Antibody (Catalog # MAB4867) or (B) Mouse IgG1 Isotype Control (Catalog # MAB002) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).

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Related Product & Information

Entrez Gene IDs	930 (Human); 12478 (Mouse); 365367 (Rat); 607898 (Canine); 102145514 (Cynomolgus Monkey); 100147468 (Equine)
Background	CD19
background_content	Background: CD19 CD19 is a 95 kDa transmembrane glycoprotein with two Ig-like C2-set domains. CD19 regulates B cell development and activation through interactions with CD21, CD22, and the B cell receptor. CD19 polymorphisms and up‑regulation lead to the development of autoimmunity by promoting autoantibody production. Within the extracellular domain, human CD19 (Accession # P15391) shares 57% amino acid sequence identity with mouse and rat CD19.

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Citations

1. Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus
   Authors: U Ellinghaus, A Cortini, CL Pinder, GL Friec, C Kemper, TJ Vyse
   Eur. J. Immunol., 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG.
   Authors: Fischer N, Elson G, Magistrelli G, Dheilly E, Fouque N, Laurendon A, Gueneau F, Ravn U, Depoisier J, Moine V, Raimondi S, Malinge P, Di Grazia L, Rousseau F, Poitevin Y, Calloud S, Cayatte P, Alcoz M, Pontini G, Fagete S, Broyer L, Corbier M, Schrag D, Didelot G, Bosson N, Costes N, Cons L, Buatois V, Johnson Z, Ferlin W, Masternak K, Kosco-Vilbois M
   Nat Commun, 2015;6(0):6113.
   


3. The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface.
   Authors: Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, Saudemont A
   PLoS ONE, 2014;9(7):e103254.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-kappaB pathway.
   J. Cell. Sci., 2012;91(6):933-45.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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