抗CD11b抗体(Anti-CD11b, Mouse-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Mouse myeloma cell line NS0-derived recombinant human CD11b/Integrin alpha MPhe17-Asn1105Accession # NP_001139280
Source	Monoclonal Mouse IgG1 Clone # 238439
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CD11b/Integrin alpha M in direct ELISAs and Western blots. In Western blots no cross-reactivity with recombinant mouse (rm) Integrins alpha 2, alpha 3, alpha 4, alpha E or rhIntegrins alpha 5, alpha V, beta 1, beta 2, beta 3, or beta 6.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	1 µg/mL	Recombinant Human Integrin  alpha M/CD11b

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Related Product & Information

Entrez Gene IDs	3684 (Human); 16409 (Mouse)
Background	CD11b/Integrin alpha M
background_content	Background: CD11b/Integrin alpha M The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.

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Citations

1. Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.
   Authors: Tanimura, Ayako, Horiguchi, Taigo, Miyoshi, Keiko, Hagita, Hiroko, Noma, Takafumi
   PLoS ONE, 2014;9(2):e89916.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


2. 1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-kappaB-dependent expression of CD55 in human monocytic THP-1 cells.
   Authors: Izban M, Nowicki B, Nowicki S
   PLoS ONE, 2012;7(11):e49318.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


3. Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammation.
   BMC Neurosci, 2012;13(0):50.
   Species: Rat
   Sample Type: Tissue Homogenates
   Application: WB


4. Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms.
   Authors: Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K
   J. Leukoc. Biol., 2007;83(3):728-41.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB


5. Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis.
   Authors: Shi Y, Tohyama Y, Kadono T, He J, Shahjahan Miah SM, Hazama R, Tanaka C, Tohyama K, Yamamura H
   Blood, 2006;107(11):4554-62.
   Species: Human
   Sample Type: Cell Lysates
   Application: WB

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