抗Integrin αX抗体(Anti-Integrin αX, Mouse-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	Rheumatoid synovial fluid cells and human monocyte-derived fibronectin
Source	Monoclonal Mouse IgG1 Clone # ICRF 3.9
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CD11c.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	2.5 µg/106 cells	Human whole blood monocytes
Immunoprecipitation	Hogg, N. et al. (1986) Eur. J. Immunol. 16:240.
CyTOF-ready	Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

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Related Product & Information

Background

CD11c

background_content

Background: CD11c CD11c, also known as Integrin alpha X, is an approximately 150 kDa type I transmembrane glycoprotein that heterodimerizes with Integrin beta 2, also known as CD18. The CD11c/CD18 complex, also called CR4 (complement receptor type 4) is expressed on macrophages, dendritic cells and hairy cell leukemias, with lower amounts on other myeloid cells and activated B, NK and some cytotoxic T cells. It binds fibrinogen and has been reported to be a receptor for complement component iC3b (1‑3). The human CD11c extracellular domain (amino acids 20-1107) shares 70 - 76% amino acid sequence identity with mouse, rat and canine CD11c.

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Citations

1. Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
   Authors: Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W
   Oncoimmunology, 2012;1(2):152-161.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells.
   Authors: Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL
   J. Immunol., 2010;184(8):4557-67.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Frozen


3. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
   Authors: Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM
   J. Immunol., 2006;177(3):1618-27.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC


4. Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to prolongation of allograft survival.
   Authors: Zhang M, Wang Q, Liu Y, Sun Y, Ding G, Fu Z, Min Z, Zhu Y, Cao X
   J. Mol. Med., 2004;82(4):240-9.
   Species: Mouse
   Sample Type:
   Application: Flow


5. Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.
   Authors: Du M, Guo P, Piao H, Wang S, Sun C, Jin L, Tao Y, Li Y, Zhang D, Zhu R, Fu Q, Li D
   J Immunol, 0;192(4):1502-11.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC

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